Abstract
A dual-channel electrospray microchip has been developed for electrospray ionization mass spectrometry (ESI-MS) where aqueous samples are mixed at the Taylor cone with an organic buffer. Due to the fast and effective mixing in the Taylor cone, the aqueous sample can be well ionized with a high ion intensity. The influence of geometric parameters such as the distance between the two microchannels at their junction at the tip of the emitter has been investigated together with chemical parameters such as the organic buffer composition.
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Acknowledgments
The authors thank the China Scholarship Council (CSC) for financial support. The authors also thank Swiss National Science Fundation (SNCF) for the funding for the project of Analytical tools for proteome analysis and redoxomics (grant no 200020_127142/1).
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Lu, Y., Liu, F., Lion, N. et al. Dual-Channel Electrospray Microchip. J. Am. Soc. Mass Spectrom. 24, 454–457 (2013). https://doi.org/10.1007/s13361-012-0547-z
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DOI: https://doi.org/10.1007/s13361-012-0547-z