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Phenotype comparison confirms ZMYND11 as a critical gene for 10p15.3 microdeletion syndrome

  • Human Genetics • Original Paper
  • Published:
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Abstract

Proper epigenetic regulation processes are crucial in the normal development of the human brain. An ever-increasing group of neurodevelopmental disorders due to derangements of epigenetic regulation involve both microdeletion and monogenic syndromes. Some of these syndromes have overlapping clinical phenotypes due to haploinsufficiency-sensitive genes involved in microdeletions. It was shown recently that the ZMYND11 gene has important functions in epigenetic regulation as an unconventional transcription co-repressor of highly expressed genes, possibly acting in the repression of cryptic transcription from gene bodies. The aim of our study was to compare the clinical phenotypes of patients with 10p15.3 deletions with the phenotypes of patients with loss-of-function ZMYND11 mutations. The results of our study further confirm that the ZMYND11 gene is the critical gene for the clinical phenotype of 10p15.3 microdeletion involving the terminal ~4 Mb of chromosome 10p. In addition, accumulating clinical data allow for further characterisation of this syndrome, including neurodevelopmental disorder, characteristic dysmorphic features and some other more frequent symptoms, such as behavioural disturbances, hypotonia, seizures, low birth weight, short stature in those older than 10 years of age, genitourinary malformations and recurrent infections.

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Acknowledgements

We are very grateful to our patients and their families for their contribution.

Author information

Authors and Affiliations

  1. Department of Human and Medical Genetics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Santariskiu 2, 08661, Vilnius, Lithuania

    Birute Tumiene, Ž. Čiuladaitė, E. Preikšaitienė, A. Utkus & V. Kučinskas

  2. Centre for Medical Genetics, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania

    Birute Tumiene, Ž. Čiuladaitė, E. Preikšaitienė, A. Utkus & V. Kučinskas

  3. Clinic of Neurology and Neurosurgery, Vilnius University, Vilnius, Lithuania

    R. Mameniškienė

Authors
  1. Birute Tumiene
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  2. Ž. Čiuladaitė
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  3. E. Preikšaitienė
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  4. R. Mameniškienė
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  5. A. Utkus
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  6. V. Kučinskas
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Corresponding author

Correspondence to Birute Tumiene.

Ethics declarations

The results of this study were in part obtained from the Lithuanian–Swiss cooperation program to reduce economic and social disparities within the enlarged European Union under project agreement no. CH-3-ŠMM-01/04, the UNIGENE project. The study was approved by the Vilnius Region Bioethics Committee.

Conflict of interest

The authors declare that they have no financial or other conflicts of interest in relation to this research and its publication.

Additional information

Communicated by: Michal Witt

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Tumiene, B., Čiuladaitė, Ž., Preikšaitienė, E. et al. Phenotype comparison confirms ZMYND11 as a critical gene for 10p15.3 microdeletion syndrome. J Appl Genetics 58, 467–474 (2017). https://doi.org/10.1007/s13353-017-0408-3

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  • DOI: https://doi.org/10.1007/s13353-017-0408-3

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