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Genetically modified pigs to model human diseases

  • Animal Genetics ∙ Review
  • Published:
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Abstract

Genetically modified mice are powerful tools to investigate the molecular basis of many human diseases. Mice are, however, of limited value for preclinical studies, because they differ significantly from humans in size, general physiology, anatomy and lifespan. Considerable efforts are, thus, being made to develop alternative animal models for a range of human diseases. These promise powerful new resources that will aid the development of new diagnostics, medicines and medical procedures. Here, we provide a comprehensive review of genetically modified porcine models described in the scientific literature: various cancers, cystic fibrosis, Duchenne muscular dystrophy, autosomal polycystic kidney disease, Huntington’s disease, spinal muscular atrophy, haemophilia A, X-linked severe combined immunodeficiency, retinitis pigmentosa, Stargardt disease, Alzheimer’s disease, various forms of diabetes mellitus and cardiovascular diseases.

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Authors and Affiliations

  1. Chair of Livestock Biotechnology, Technische Universität München, Liesel-Beckmann-Str. 1, 85354, Freising, Germany

    Tatiana Flisikowska, Alexander Kind & Angelika Schnieke

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  1. Tatiana Flisikowska
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  2. Alexander Kind
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  3. Angelika Schnieke
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Correspondence to Tatiana Flisikowska.

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Flisikowska, T., Kind, A. & Schnieke, A. Genetically modified pigs to model human diseases. J Appl Genetics 55, 53–64 (2014). https://doi.org/10.1007/s13353-013-0182-9

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  • DOI: https://doi.org/10.1007/s13353-013-0182-9

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