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Effect of Rehydration With Normal Saline Versus Ringer Lactate on Serum Sodium Level of Children With Acute Diarrhea and Severe Dehydration: A Randomized Controlled Trial

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Abstract

Objective

To demonstrate the equivalence of Normal Saline (NS) and Ringer Lactate (RL) for change in serum sodium levels during correction of severe dehydration in children with acute diarrhea based on World Health Organization (WHO) plan C.

Design

Equivalence randomized control trial.

Setting

Pediatric diarrhea unit of a tertiary care hospital from May, 2016 to April, 2017.

Participants

72 children of 1–12 years with acute diarrhea and severe dehydration were enrolled. Children with dysentery, severe acute malnutrition, severe anemia, meningitis, and known surgical and systemic diseases were excluded.

Intervention

RL (n=36) or NS (n=36) were used as per WHO plan C. Blood samples were drawn before intravenous fluid correction and 3 h post-intervention.

Outcome Measures

Mean change in serum sodium level from the baseline between the RL and NS groups.

Results

70 children (35 in each group) completed the study. The difference in mean serum sodium levels from baseline in RL and NS groups were 1.4 (4.5) mEq/L and 2.1(4.9) mEq/L, respectively (P=0.58).

Conclusions

Both RL and NS are equivalent in terms of change in serum sodium from baseline for intravenous rehydration in children with acute diarrhea and severe dehydration.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India

    Md Naseem, A. P. Dubey & Raghvendra Singh

  2. Department of Biochemistry, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi, India

    T. K. Mishra

Authors
  1. Md Naseem
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  2. A. P. Dubey
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  3. T. K. Mishra
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  4. Raghvendra Singh
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Contributions

MN,APD,RS: involved in execution of the study, data analysis and writing the manuscript; TKM: contributed in execution of the study, data analysis and writing the manuscript.

Corresponding author

Correspondence to Raghvendra Singh.

Ethics declarations

Institutional Ethics Committee for Human Research, Maulana Azad Medical College; No. 11/IEC/MAMC/2015/317.

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Naseem, M., Dubey, A.P., Mishra, T.K. et al. Effect of Rehydration With Normal Saline Versus Ringer Lactate on Serum Sodium Level of Children With Acute Diarrhea and Severe Dehydration: A Randomized Controlled Trial. Indian Pediatr 57, 519–522 (2020). https://doi.org/10.1007/s13312-020-1848-0

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  • DOI: https://doi.org/10.1007/s13312-020-1848-0

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