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Bronchopulmonary Dysplasia in Preterm Neonates in a Level III Neonatal Unit in India

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Abstract

Objective

To find out the incidence and associations of bronchopulmonary dysplasia (BPD) in preterm neonates.

Design

Descriptive cohort.

Methods

All consecutively born neonates <33 weeks gestation requiring oxygen or respiratory support during first 3 days of life were enrolled from a level III neonatal unit in Chandigarh, India. Those with malformations were excluded. Placenta was examined for histological chorioamnionitis in preterm rupture of membranes and/or preterm spontaneous onset of labour. Serum Malondialdehyde (MDA) and Superoxide dismutase (SOD) and Catalase levels were estimated on day 3 of life. All recruited neonates were followed up till discharge or death.

Results

Out of 250 neonates enrolled, 170 (68%) survived till day 28 and BPD developed in 19 (11.2%) infants. The mean gestation and birth weight were significantly lower in infants who developed BPD. Chorioamnionitis (clinical 5.3% vs 1.9%, P=0.375; and histological 37.5% vs 16.7%, P<0.001), patent ductus arteriosus (PDA) (52.6% vs 8.9%, P<0.001), median (IQR) sepsis episodes [2 (2,3) vs 1 (1,2), P<0.001], invasive ventilation (84.2% vs 11.3%, P<0.001), and duration of ventilation [56 (4) d vs 4 (5) d, P=0.001] were significantly higher in infants with BPD. Serum MDA, SOD and Catalase levels were comparable between the two groups.

Conclusion

Chorioamnionitis, PDA and sepsis were significantly associated with BPD.

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Authors and Affiliations

  1. Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, 160 012, India

    Savita Bhunwal & Kanya Mukhopadhyay

  2. Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Shalmoli Bhattacharya

  3. Department of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Pranab Dey

  4. Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

    Lakhbir Kaur Dhaliwal

Authors
  1. Savita Bhunwal
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  2. Kanya Mukhopadhyay
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  3. Shalmoli Bhattacharya
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  4. Pranab Dey
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  5. Lakhbir Kaur Dhaliwal
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Corresponding author

Correspondence to Kanya Mukhopadhyay.

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Bhunwal, S., Mukhopadhyay, K., Bhattacharya, S. et al. Bronchopulmonary Dysplasia in Preterm Neonates in a Level III Neonatal Unit in India. Indian Pediatr 55, 211–215 (2018). https://doi.org/10.1007/s13312-018-1319-z

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  • DOI: https://doi.org/10.1007/s13312-018-1319-z

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