Abstract
Objective
To evaluate the efficacy of pre-exchange transfusion albumin priming in neonates with non-hemolytic hyperbilirubinemia.
Design
Single center, randomized controlled trial.
Setting
Level III Neonatal unit.
Participants
Fifty healthy term and late preterm neonates with non-hemolytic hyperbilirubinemia requiring exchange transfusion.
Interventions
5 mL/kg of either 20% human albumin (n=23) or 0.9% saline (n=27) infusion one hour prior to exchange transfusion.
Main outcome measure
Post-exchange transfusion phototherapy duration.
Results
The post-exchange transfusion phototherapy duration was not different between albumin and saline groups [Median (IQR): 29 (24-48) h vs. 33 (24-43) h; P=0.76]. The total amount of bilirubin removed during exchange transfusion was also similar [Median (IQR): 34 (28-46) mg vs. 33 (27-38) mg; P=0.46]. Serial changes in total serum bilirubin following exchange transfusion and need for repeat exchange transfusion were comparable between the groups.
Conclusion
In healthy late preterm and term neonates with non-hemolytic hyperbilirubinemia, priming with 1 g/kg of 20% albumin prior to exchange transfusion is not superior to equivolume 0.9% saline in reducing post-exchange transfusion phototherapy duration or amount of bilirubin mass removed.
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Dash, N., Kumar, P., Sundaram, V. et al. Pre-exchange albumin administration in neonates with hyperbilirubinemia: A randomized controlled trial . Indian Pediatr 52, 763–767 (2015). https://doi.org/10.1007/s13312-015-0713-z
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DOI: https://doi.org/10.1007/s13312-015-0713-z