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Oral sucrose for pain in neonates during echocardiography: A Randomized Controlled Trial

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Abstract

Objectives

To test the efficacy of oral sucrose in reducing pain/ stress during echocardiography as estimated by Premature Infant Pain Profile score.

Design

Double-blind, parallel-group, randomized control trial.

Setting

Tertiary-care neonatal care unit located in Western India.

Participants

Neonates with established enteral feeding, not on any respiratory support and with gestational age between 32 and 42 weeks requiring echocardiography.

Interventions

Neonates in intervention group received oral sucrose prior to echocardiography.

Main outcome measures

Assessment was done using Premature Infant Pain Profile score.

Results

There were 104 examinations; 52 in each group. Baseline characteristics like mean gestational age (37.6 vs. 37.1), birth weight (2.20 vs. 2.08), and feeding status (Breastfeeding- 59.6% vs. 44.2%, paladai feeding- 13.5% vs. 13.5%, and gavage feeding- 26.9% vs. 42.3%) were comparable. The mean (SD) premature infant pain profile score was significantly higher in control group [(7.4 (3.78) vs. 5.2 (1.92), P <0.001].

Conclusion

Oral sucrose significantly reduces pain, and is safe to administer to neonates.

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Authors and Affiliations

  1. Department of Pediatrics, Pramukhswami Medical College, Karamsad-Anand, Gujarat, 388 325, India

    Nirav T. Potana, Ashish R. Dongara, Somashekhar M. Nimbalkar & Dipen V. Patel

  2. Departments of Physiology, Pramukhswami Medical College, Karamsad, Gujarat, India

    Archana S. Nimbalkar

  3. Departments of Central Research Services, Charutar Arogya Mandal, Karamsad, Gujarat, India

    Ajay Phatak

Authors
  1. Nirav T. Potana
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  2. Ashish R. Dongara
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  3. Somashekhar M. Nimbalkar
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  4. Dipen V. Patel
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  5. Archana S. Nimbalkar
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  6. Ajay Phatak
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Corresponding author

Correspondence to Somashekhar M. Nimbalkar.

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Potana, N.T., Dongara, A.R., Nimbalkar, S.M. et al. Oral sucrose for pain in neonates during echocardiography: A Randomized Controlled Trial . Indian Pediatr 52, 493–497 (2015). https://doi.org/10.1007/s13312-015-0663-5

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  • DOI: https://doi.org/10.1007/s13312-015-0663-5

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