Thyroid nodules are uncommon in childhood and recurrent thyroid nodules even rarer. Spindle epithelial tumor with thymus-like differentiation (SETTLE), a rare and distinctive lowgrade neoplasm is amongst the differential diagnosis of solitary thyroid nodule in children. We describe a boy who underwent completion thyroidectomy for SETTLE in the thyroid remnant four years after initial lobectomy was performed for the same diagnosis. Patients with SETTLE are to be closely followed as multifocality may manifest and be detected later.
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References
Hegedüs L. The thyroid nodule. N Engl J Med. 2004;351:1764–1771.
Niedziela M. Pathogenesis, diagnosis and management of thyroid nodules in children. Endocr Relat Cancer. 2006;13:427.
Weigensberg C, Dalsley H, Asa SL, Bedard YC, Muelen JBM. Thyroid thymoma in childhood. Endocr Pathol. 1990;1:123–127.
Chan JKC, Rosai J. Tumor of the neck showing thymic or related branchial pouch differentiation: a unifying concept. Hum Pathol. 1991;22:349–367.
Grushka JR, Ryckman J, Mueller C, Roessingh ADB, Walton JM, Vil DS, et al. Spindle epithelial tumor with thymus-like elements of the thyroid: a multi-institutional case series and review of the literature. J Pediatr Surg. 2009;44:944–948.
Haberal AN, Aydin H, Turan E, Demirhan B. Unusual spindle cell tumor of thyroid (SETTLE). Thyroid. 2008;18:85–87.
Cheuk W, Jacobson AA, Chan JK. Spindle epithelial tumor with thymus-like differentiation (SETTLE): a distinctive malignant thyroid neoplasm with significant metastatic potential. Mod Pathol. 2000;13:1150–1155.
Iwasa K, Imai MA, Noguchi M, Tanaka S, Sasaki T, Katsuda S, et al. Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid. Head Neck. 2002;24:888–893.
Kloboves-Prevodnik V, Jazbec J, Us-Krasovec M, Lamovec J. Thyroid spindle epithelial tumor with thymuslike differentiation (SETTLE): Is cytopathological diagnosis possible? Diagn Cytopathol. 2002;26:314–319.
Erickson ML, Tapia B, Moreno ER, McKnee MA, Kowalski DP, Reyes-Mugica M. Early metastasizing spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid. Pediatr Develop Pathol. 2005;8:599–606.
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Rastogi, A., Saikia, U.N., Gupta, A.K. et al. Recurrent Thyroid Nodule: Spindle Epithelial Tumor with Thymus-like Differentiation (SETTLE). Indian Pediatr 49, 482–484 (2012). https://doi.org/10.1007/s13312-012-0091-8
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DOI: https://doi.org/10.1007/s13312-012-0091-8