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Outcomes of hepatoblastoma in the Indian context

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Abstract

A comprehensive review and critical appraisal of published and grey literature was undertaken to identify current treatment practices and outcomes of children with hepatoblastoma in India. Eight single-centre studies with 157 patients (range five to 36 patients in each study) were included. Pre-operative chemotherapy (mainly cisplatin and doxorubicin) followed by surgical resection and additional chemotherapy was the usual practice. There was no stratification of treatment by risk group in any of the studies. The median event-free survival ranged from 33–100%. The two main reasons for treatment failure were treatment-related mortality (0–50%) and progression of disease (0–30%).

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References

  1. Pritchard J, Brown J, Shafford E, Perilongo G, Brock P, Dicks-Mireaux C, et al. Cisplatin, doxorubicin, and delayed surgery for childhood hepatoblastoma: a successful approach-results of the first prospective study of the International Society of Pediatric Oncology. J Clin Oncol. 2000;18:3819–3828.

    PubMed  CAS  Google Scholar 

  2. Exelby PR, Filler RM, Grosfeld JL. Liver tumors in children in the particular reference to hepatoblastoma and hepatocellular carcinoma: American Academy of Pediatrics Surgical Section Survey-1974. J Pediatr Surg. 1975;10:329–337.

    Article  PubMed  CAS  Google Scholar 

  3. Ortega JA, Douglass EC, Feusner JH, Reynolds M, Quinn JJ, Finegold MJ, et al. Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children’s Cancer Group and the Pediatric Oncology Group. J Clin Oncol. 2000;18:2665–2675.

    PubMed  CAS  Google Scholar 

  4. Shah PM, Shah R, Shah N. Heptoblastoma — GCRI experience [abstract]. Med Pediatr Oncol. 2001;37:288.

    Google Scholar 

  5. Udupa KV, Navadgi SM, Mullerpatan P, Chhabra D, Shah RC, Jagannath P. Neoadjuvant chemotherapy before surgery of hepatoblastoma. Indian J Pediatr. 2006;73:735–737.

    Article  PubMed  CAS  Google Scholar 

  6. Agarwala S, Bakshi S, Bajpai M, Bhatnagar V, Gupta AK, SD Gupta, et al. Validation of PRETEXT staging system and risk categorization for prognostication and outcome in hepatoblastoma — results from AIIMS-HB94 trial [abstract]. Pediatr Blood Cancer. 2007;49:401–402.

    Google Scholar 

  7. Mehta P, Buch N, Swami A, Bhatnagar S, Shah N, Desai M, et al. Difficulties faced during treatment of hepatoblastoma — an Indian experience from a tertiary charitable trust hospital [abstract]. Pediatr Blood Cancer. 2007;49:535–536.

    Google Scholar 

  8. Thankamony P, Raghavan H, Kattoor J, Parukutty K. Hepatoblastoma — ten year experience from Regional Cancer Centre, Thiruvanathapuram, Kerala, South India [abstract]. Pediatr Blood Cancer. 2007;49:535.

    Google Scholar 

  9. Shukla PJ, Barreto SG, Qureshi SS, Hawaldar R, Shrikhande SV, Ramadwar MR, et al. Hepatoblastoma: a single institutional experience of 18 cases. Pediatr Surg Int. 2008;24:799–802.

    Article  PubMed  Google Scholar 

  10. Singh T, Satheesh CT, Appaji L, Aruna Kumari BS, Padma M, Kumar MV, et al. Hepatoblastoma: Experience from a single center. Indian J Cancer. 2010;47:314–316.

    Article  PubMed  CAS  Google Scholar 

  11. Cyriac S, Seshadri RA, Warrier A, Sagar TG. Hepatoblastoma: Analysis of treatment outcome from a tertiary care center. J Indian Assoc Pediatr Surg. 2011;16:11–14.

    Article  PubMed  Google Scholar 

  12. Perilongo G, Maibach R, Shafford E, Brugieres L, Brock P, Morland B, et al. Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma. N Engl J Med. 2009;361:1662–1670.

    Article  PubMed  CAS  Google Scholar 

  13. Arora RS, Pizer B, Eden TO. Understanding refusal and abandonment in the treatment of childhood cancer. Indian Pediatr. 2010;47:1005–1010.

    Article  PubMed  CAS  Google Scholar 

  14. Agarwala S, Ronghe MD, Aronson DC, Czauderna P, Brock P, Roebuck D, et al. Pilot of treatment guidelines for hepatoblastoma (HB) in resource challenged nations (RCN) [abstract]. Pediatr Blood Cancer. 2009;53:717.

    Google Scholar 

  15. Zsíros J, Maibach R, Shafford E, Brugieres L, Brock P, Czauderna P, et al. Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study. J Clin Oncol. 2010;28:2584–2590.

    Article  PubMed  Google Scholar 

  16. Rao S, D’Cruz AL, Aggarwal R, Chandrashekar S, Chetan G, Gopalakrishnan G, et al. Pediatric liver transplantation: A report from a pediatric surgical unit. J Indian Assoc Pediatr Surg. 2011;16:2–7.

    Article  PubMed  Google Scholar 

  17. Shafford EA, Pritchard J. Liver tumours. In: Pinkerton R, Plowman PN, Pieters R, editors. Paediatric Oncology. 3rd ed. London: Arnold; 2004. p. 448–468.

    Google Scholar 

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Authors and Affiliations

  1. Alder Hey Hospital, Liverpool, UK

    Ramandeep Singh Arora

  2. 19 Wet Earth Green, Swinton, Manchester, UK, M27 8AL

    Ramandeep Singh Arora

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  1. Ramandeep Singh Arora
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Correspondence to Ramandeep Singh Arora.

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Arora, R.S. Outcomes of hepatoblastoma in the Indian context. Indian Pediatr 49, 307–309 (2012). https://doi.org/10.1007/s13312-012-0037-1

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  • DOI: https://doi.org/10.1007/s13312-012-0037-1

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