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Pituitary hyperplasia in children with short stature and primary hypothyroidism

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Abstract

We present eight cases with short stature, pituitary hyperplasia, and hypothyroidism. Pituitary hyperplasia due to primary hypothyroidism was diagnosed on the basis of clinical manifestations, endocrine examination and MRI. After 2 to 6 months of L-thyroxine replacement therapy, the signs of hypothyroidism disappeared; free triiodothyronine, free thyroxine, thyrotropin and prolactin became normal; and pituitary enlargement regressed. In two children, the growth rate remained low when treated with L-thyroxine, but with additional recombinant human growth hormone (rhGH), the height increased by 11 cm per year. No recurrence of lesions was found on follow-up.

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Authors and Affiliations

  1. Department of Pediatrics, The Affiliated Hospital of QingDao Medical College, QingDao University, QingDao, 266 003, China

    Aijing Xu & Tang Li

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  1. Aijing Xu
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  2. Tang Li
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Correspondence to Tang Li.

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Xu, A., Li, T. Pituitary hyperplasia in children with short stature and primary hypothyroidism. Indian Pediatr 47, 877–880 (2010). https://doi.org/10.1007/s13312-010-0149-4

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  • DOI: https://doi.org/10.1007/s13312-010-0149-4

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