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Downregulation of lncRNA-ATB correlates with clinical progression and unfavorable prognosis in pancreatic cancer

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Tumor Biology

Abstract

Long noncoding RNAs (lncRNAs) have been shown to play critical roles in the development and progression of diseases. lncRNA activated by transforming growth factor beta (TGF-β) (lncRNA-ATB) was discovered as a prognostic factor in hepatocellular carcinoma, gastric cancer, and colorectal cancer. However, little is known about the role of lncRNA-ATB in pancreatic cancer. This study aimed to assess lncRNA-ATB expression in pancreatic cancer and explore its role in pancreatic cancer pathogenesis. Quantitative real-time polymerase chain reaction was performed to detect lncRNA-ATB expression in 150 pancreatic cancer tissues and five pancreatic cancer cell lines compared to paired adjacent normal tissues and normal human pancreatic ductal epithelial cell line HPDE6c-7. The correlations between lncRNA-ATB expression and clinicopathological characteristics and prognosis were also analyzed. We found that lncRNA-ATB expression was decreased in pancreatic cancer tissues and pancreatic cancer cell lines. Low lncRNA-ATB expression levels were significantly correlated with lymph node metastases (yes vs. no, P = 0.009), neural invasion (positive vs. negative, P = 0.049), and clinical stage (early stage vs. advanced stage, P = 0.014). Moreover, patients with low lncRNA-ATB expression levels exhibited markedly worse overall survival prognoses (P < 0.001). Multivariate analysis indicated that decreased lncRNA-ATB expression was an independent predictor of poor prognosis in pancreatic cancer patients (P = 0.005). In conclusion, lncRNA-ATB may play a critical role in pancreatic cancer progression and prognosis and may serve as a potential prognostic biomarker in pancreatic cancer patients.

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Acknowledgments

We would like to thank Yan Qiu and Kun Liu (Department of Hepatobiliary Surgery of Xijing Hospital) for collecting the samples and the follow-up information. We thank Xuejun Hu and Zhidong Wang (Fourth Military Medical University) for his help in statistics. We are also grateful for the anonymous reviewers’ constructive comments and suggestions. This work was supported by grants from the National Natural Science Foundation of China (No. 81772061) and the Health Public Welfare Industry Special Scientific Research Projects of China (No.201202007).

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    Authors and Affiliations

    1. Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China

      Shibin Qu, Xisheng Yang, Wenjie Song, Wei Sun, Xiaolei Li, Jianlin Wang, Yue Zhong, Runze Shang, Bai Ruan, Zhuochao Zhang, Xuan Zhang & Haimin Li

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    1. Shibin Qu
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    Correspondence to Haimin Li.

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    Shibin Qu, Xisheng Yang and Wenjie Song contributed equally to this work.

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    Qu, S., Yang, X., Song, W. et al. Downregulation of lncRNA-ATB correlates with clinical progression and unfavorable prognosis in pancreatic cancer. Tumor Biol. 37, 3933–3938 (2016). https://doi.org/10.1007/s13277-015-4252-y

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