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RETRACTED ARTICLE: Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer

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Tumor Biology

21 December 2021 This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.3233/TUB-219010 "

An Erratum to this article was published on 30 October 2015

Abstract

Overexpression of HOTAIR (HOX antisense intergenic RNA) is significantly correlated with tumor progression and poor prognosis in human ovarian cancer. However, the underlying mechanisms are largely unknown. In the present study, we investigated the roles of HOTAIR in the initiation and chemoresistance of ovarian cancer. As our data show, HOTAIR overexpression promoted cell cycle progression (and thus cell proliferation) by activating the wnt/β-catenin signaling pathway. Likewise, knockdown of HOTAIR suppressed cell proliferation and arrested cell cycle at G1 phase via inhibition of wnt/β-catenin signaling. Moreover, the results of primary culture demonstrated that elevated HOTAIR expression correlated positively with chemoresistance in ovarian cancer. In vitro and in vivo, HOTAIR induced cellular resistance to cisplatin by activating the wnt/β-catenin pathway, which could be reversed by pre-treatment with the wnt/β-catenin inhibitor, XAV939. In conclusion, HOTAIR promotes the initiation and chemoresistance of ovarian cancer by activating wnt/β-catenin signaling, suggesting that HOTAIR might be a potent therapeutic target for ovarian cancer treatment.

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Acknowledgments

Our study was supported by the Postdoctoral Science Foundation of China to Jing Li (2015M570635) and to Haifeng Qiu (2015M570634), and the National Natural Science Funds to Jing Li (81502262) and to Haifeng Qiu (81502261).

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    Authors and Affiliations

    1. Department of Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China

      Jing Li

    2. Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated International Peace Maternity and Child Health Hospital, No. 910, Hengshan Road, Xujiahui District, Shanghai, 200030, China

      Siqin Yang & Xiaoying He

    3. Department of Gynecologic Oncology, the Affiliated Cancer Hospital of Zhengzhou University and Henan Provincal Cancer Hospital, Zhengzhou, Henan Province, 450008, China

      Ning Su

    4. Department of Obstetrics and Gynecology, the Affiliated Hospital of Jiangnan University and the 4th People’s Hospital of Wuxi, Wuxi, Jiangsu Province, 214062, China

      Yuan Wang & Jinjin Yu

    5. Department of Obstetrics and Gynecology, the First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Road, Erqi District, Zhengzhou, Henan Province, 450052, China

      Haifeng Qiu

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    1. Jing Li
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    4. Yuan Wang
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    Correspondence to Haifeng Qiu or Xiaoying He.

    Additional information

    This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.3233/TUB-219010"

    Jing Li, Siqin Yang and Xiaoying He contributed equally to this work.

    An erratum to this article is available at http://dx.doi.org/10.1007/s13277-015-4210-8.

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    Li, J., Yang, S., Su, N. et al. RETRACTED ARTICLE: Overexpression of long non-coding RNA HOTAIR leads to chemoresistance by activating the Wnt/β-catenin pathway in human ovarian cancer. Tumor Biol. 37, 2057–2065 (2016). https://doi.org/10.1007/s13277-015-3998-6

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    • DOI: https://doi.org/10.1007/s13277-015-3998-6

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