Abstract
Competing endogenous RNAs (ceRNAs) are RNA transcripts which can communicate with each other by decreasing targeting concentration of micro-RNA (miRNA) with the derepression of other messenger RNAs (mRNAs) having the common miRNA response elements (MREs). Oncocers are ceRNAs taking crucial roles in oncogenic pathways processed in many types of cancer, and this study analyzes oncocer-mediated cross-talk by sponging microRNAs (miRNAs) in these pathways. While doing this, breast, liver, colon, prostate, gastric, lung, endometrium, thyroid and epithelial cancers and melanoma, rhabdomyosarcoma, glioblastoma, acute promyelocytic leukemia, retinoblastoma, and neuroblastoma were analyzed with respect to ceRNA-based carcinogenesis. This study defines, firstly, oncocers in the literature and contains all oncocer-related findings found up to now. Therefore, it will help to increase our comprehension about oncocer-mediated mechanisms. Via this study, a novel perspective would be produced to make clear cancer mechanisms and suggest novel approaches to regulate ceRNA networks via miRNA competition for cancer therapeutics.
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Abbreviations
- 3′-UTR:
-
3′-Untranslated region
- ARM:
-
Alveolar rhabdomyosarcoma
- ATXN3:
-
Ataxin 3
- ceRNA:
-
Competing endogenous RNA
- ceRNET:
-
ceRNA network
- EMT:
-
Epithelial-to-mesenchymal transition
- ERM:
-
Embryonic rhabdomyosarcoma
- ET:
-
Endometrial tumorspheres
- FGFR4:
-
Fibroblast growth factor receptor 4
- HDACi:
-
Histone deacetylase inhibitors
- HULC:
-
Highly upregulated in liver cancer
- IGFR1:
-
Insulin like growth factor 1 receptor
- lncRNA:
-
Long noncoding RNAs
- miRNA:
-
Micro RNA
- MRE:
-
MiRNA response element
- ncRNA:
-
Noncoding RNA
- PTCSC3:
-
Papillary thyroid carcinoma susceptibility candidate 3
- ZEB:
-
Zinc finger E-box-binding homeobox
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Ergun, S., Oztuzcu, S. Oncocers: ceRNA-mediated cross-talk by sponging miRNAs in oncogenic pathways. Tumor Biol. 36, 3129–3136 (2015). https://doi.org/10.1007/s13277-015-3346-x
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DOI: https://doi.org/10.1007/s13277-015-3346-x