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Kindlin-2 inhibited the growth and migration of colorectal cancer cells

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Tumor Biology

Abstract

Activation of Wingless (Wnt)/beta-catenin signaling is a hallmark of colorectal carcinoma (CRC). It is very important to find out the molecular mechanism for the hyperactivation of Wnt/beta-catenin signaling and identify novel therapeutic targets. Kindlin-2, a regulator of integrins, recently has been found to be involved in the tumorigenesis. However, its expression profile and functions in the progression of CRC remain poorly understood. Here, we found that the expression of Kindlin-2 was downregulated in the CRC tissues. Moreover, overexpression of Kindlin-2 in CRC cells and normal colon epithelial cells inhibited cell proliferation and migration, while downregulation of Kindlin-2 promoted the tumorigenecity of CRC cells in vitro and in vivo. Mechanistically, Kindlin-2 decreased the phosphorylation of Ser9 in glycogen synthase kinase (GSK) 3beta and promoted the ubiquitination of beta-catenin. Taken together, our study suggests the suppressive roles of Kindlin-2 in the pathogenesis of CRC.

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    Authors and Affiliations

    1. Department of Oncology, The People’s Hospital of Taizhou, Taizhou, Jiangsu Province, China

      Yuanyuan Ren, Hongsong Jin, Zhidong Xue, Qianlang Xu & Songhua Wang

    2. Department of Pathology, The People’s Hospital of Taizhou, Taizhou, Jiangsu Province, China

      Guojun Zhao

    3. The Institute of Cancer Research, 399 South of Hailing Rd, Taizhou, Jiangsu Province, China

      Junxing Huang & He Huang

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    1. Yuanyuan Ren
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    2. Hongsong Jin
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    3. Zhidong Xue
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    4. Qianlang Xu
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    5. Songhua Wang
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    6. Guojun Zhao
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    7. Junxing Huang
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    8. He Huang
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    Correspondence to Junxing Huang or He Huang.

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    Yuanyuan Ren and Hongsong Jin contributed equally to this work.

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    Ren, Y., Jin, H., Xue, Z. et al. Kindlin-2 inhibited the growth and migration of colorectal cancer cells. Tumor Biol. 36, 4107–4114 (2015). https://doi.org/10.1007/s13277-015-3044-8

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    • DOI: https://doi.org/10.1007/s13277-015-3044-8

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