Skip to main content

Advertisement

SpringerLink
Log in

MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies

  • Research Article
  • Published:
Tumor Biology

A Commentary to this article was published on 27 January 2016

Abstract

MT1-MMP exhibits diverse expressions in patients with cancer and could be considered as potential prognostic biomarker of cancer. We performed a meta-analysis aiming to provide more sufficient evidence that MT1-MMP expression is associated with poor overall survival in several types of cancers. We systematically searched the studies from databases and carefully identified based on eligibility criteria. The association between MT1-MMP expression and overall survival in cancers was estimated using Review Manager. A total of 11 literatures which included 1,918 cancer patients were combined in the final analysis. Meta-analysis revealed that MT1-MMP overexpression was associated with an unfavorable overall survival and the pooled hazard ratio (HR) and corresponding 95 % confidence interval (CI) was 2.46 (95 % CI 1.75–3.47). From subgroup analyses, we identified that MT1-MMP was an independent prognostic factor for lung cancer and gastric cancer, and HRs (95 % CI) were 3.73 (95 % CI 2.67–5.21) and 2.46 (95 % CI 1.69–3.59), respectively. In conclusion, MT1-MMP is a potential prognostic factor in human cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

Abbreviations

MT1-MMP:

Membrane type 1 matrix metalloproteinase

OS:

Overall survival

HR:

Hazard ratio

CI:

Confidence interval

References

  1. Pahwa S, Stawikowski MJ, Fields GB. Monitoring and inhibiting MT1-MMP during cancer initiation and progression. Cancers. 2014;6:416–35.

    Article  Google Scholar 

  2. Genis L, Galvez BG, Gonzalo P, Arroyo A. MT1-MMP: universal or particular player in angiogenesis? Cancer Metastasis Rev. 2006;25:77–86.

    Article  Google Scholar 

  3. Jiang WG, Davies G, Martin TA, Parr C, Watkins G, Mason MD, et al. Expression of membrane type-1 matrix metalloproteinase, MT1-MMP in human breast cancer and its impact on invasiveness of breast cancer cells. Int J Mol Med. 2006;17:583–90.

    PubMed  Google Scholar 

  4. Takino T, Tsuge H, Ozawa T, Sato H. MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix. Biochem Biophys Res Commun. 2010;396:1042–7.

    Article  CAS  Google Scholar 

  5. Tolde O, Rosel D, Mierke CT, Pankova D, Folk P, Vesely P, et al. Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP. Int J Oncol. 2010;36:833–9.

    CAS  PubMed  Google Scholar 

  6. Lafleur MA, Xu D, Hemler ME. Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis. Mol Biol Cell. 2009;20:2030–40.

    Article  CAS  Google Scholar 

  7. Strongin AY. Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy. Biochim Biophys Acta. 1803;2010:133–41.

    Google Scholar 

  8. Tomari T, Koshikawa N, Uematsu T, Shinkawa T, Hoshino D, Egawa N, et al. High throughput analysis of proteins associating with a proinvasive MT1-MMP in human malignant melanoma A375 cells. Cancer Sci. 2009;100:1284–90.

    Article  CAS  Google Scholar 

  9. Shields MA, Dangi-Garimella S, Redig AJ, Munshi HG. Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression. Biochem J. 2012;441:541–52.

    Article  CAS  Google Scholar 

  10. Xu M, Wang YZ. miR-133a suppresses cell proliferation, migration and invasion in human lung cancer by targeting MMP-14. Oncol Rep. 2013;30:1398–404.

    Article  CAS  Google Scholar 

  11. Michael M, Babic B, Khokha R, Tsao M, Ho J, Pintilie M, et al. Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer. J Clin Oncol. 1999;17:1802–8.

    Article  CAS  Google Scholar 

  12. Massi D, Franchi A, Ketabchi S, Paglierani M, Pimpinelli N, Santucci M. Expression and prognostic significance of matrix metalloproteinases and their tissue inhibitors in primary neuroendocrine carcinoma of the skin. Hum Pathol. 2003;34:80–8.

    Article  CAS  Google Scholar 

  13. Tetu B, Brisson J, Wang CS, Lapointe H, Beaudry G, Blanchette C, et al. The influence of MMP-14, TIMP-2 and MMP-2 expression on breast cancer prognosis. Breast Cancer Res. 2006;8:R28.

    Article  Google Scholar 

  14. Crispi S, Calogero RA, Santini M, Mellone P, Vincenzi B, Citro G, et al. Global gene expression profiling of human pleural mesotheliomas: Identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target. PLoS One. 2009;4:e7016.

    Article  Google Scholar 

  15. He L, Chu D, Li X, Zheng J, Liu S, Li J, et al. Matrix metalloproteinase-14 is a negative prognostic marker for patients with gastric cancer. Dig Dis Sci. 2013;58:1264–70.

    Article  CAS  Google Scholar 

  16. Peng CW, Wang LW, Fang M, Yang GF, Li Y, Pang DW. Combined features based on MT1-MMP expression, CD11b+ immunocytes density and LNR predict clinical outcomes of gastric cancer. J Transl Med. 2013;11:153.

    Article  CAS  Google Scholar 

  17. Wang L, Yuan J, Tu Y, Mao X, He S, Fu G, et al. Co-expression of MMP-14 and MMP-19 predicts poor survival in human glioma. Clin Trans Oncol. 2013;15:139–45.

    Article  CAS  Google Scholar 

  18. Yang B, Gao J, Rao Z, Shen Q. Clinicopathological and prognostic significance of alpha5beta1-integrin and MMP-14 expressions in colorectal cancer. Neoplasma. 2013;60:254–61.

    Article  CAS  Google Scholar 

  19. Trudel D, Desmeules P, Turcotte S, Plante M, Gregoire J, Renaud MC, et al. Visual and automated assessment of matrix metalloproteinase-14 tissue expression for the evaluation of ovarian cancer prognosis. Mod Pathol. 2014. doi:10.1038/modpathol.2014.32.

  20. Akanuma N, Hoshino I, Akutsu Y, Murakami K, Isozaki Y, Maruyama T, et al. MicroRNA-133a regulates the mRNAs of two invadopodia-related proteins, FSCN1 and MMP14, in esophageal cancer. Br J Cancer. 2014;110:189–98.

    Article  CAS  Google Scholar 

  21. Wang YZ, Wu KP, Wu AB, Yang ZC, Li JM, Mo YL, et al. MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer. Tomour Biol. 2014. doi:https://doi.org/10.1007/s13277-014-2237-x.

    Article  Google Scholar 

  22. Zhang H, Liu M, Sun Y, Lu J, et al. MMP-14 can serve as a prognostic marker in patients with supraglottic cancer. Eur Arch Otorhinolaryngol. 2009;266:1427–34.

    Article  Google Scholar 

  23. Trudel D, Fradet Y, Meyer F, Harel F, Tetu B. Membrane-type-1 matrix metalloproteinase, matrix metalloproteinase 2, and tissue inhibitor of matrix proteinase 2 in prostate cancer: identification of patients with poor prognosis by immunohistochemistry. Hum Pathol. 2008;39:731–9.

    Article  CAS  Google Scholar 

  24. Kondratiev S, Gnepp DR, Yakirevich E, Sabo E, Annino DJ, Rebeiz E, et al. Expression and prognostic role of MMP2, MMP9, MMP13, and MMP14 matrix metalloproteinases in sinonasal and oral malignant melanomas. Hum Pathol. 2008;39:337–43.

    Article  CAS  Google Scholar 

  25. Mylona E, Nomikos A, Magkou C, Kamberou M, Papassideri I, Keramopoulos A, et al. The clinicopathological and prognostic significance of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-9 according to their localization in invasive breast carcinoma. Histopathology. 2007;50:338–47.

    Article  CAS  Google Scholar 

  26. Sagara Y, Miyata Y, Iwata T, Kanda S, Hayashi T, Sakai H, et al. Clinical significance and prognostic value of S100A4 and matrix metalloproteinase-14 in patients with organ-confined bladder cancer. Exp Ther Med. 2010;1:27–31.

    PubMed  PubMed Central  Google Scholar 

  27. Maatta M, Soini Y, Liakka A, Autio-Harmainen H. Differential expression of matrix metalloproteinase (MMP)-2, MMP-9, and membrane type 1-MMP in hepatocellular and pancreatic adenocarcinoma: implications for tumor progression and clinical prognosis. Clin Cancer Res. 2000;6:2726–34.

    CAS  PubMed  Google Scholar 

  28. Uchibori M, Nishida Y, Nagasaka T, Yamada Y, Nakanishi K, Ishiguro N. Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. Int J Oncol. 2006;28:33–42.

    CAS  PubMed  Google Scholar 

  29. Yoshizaki T, Maruyama Y, Sato H, Furukawa M. Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma. Int J Cancer. 2001;95:44–50.

    Article  CAS  Google Scholar 

  30. Zarrabi K, Dufour A, Li J, Kuscu C, Pulkoski-Gross A, Zhi J, et al. Inhibition of matrix metalloproteinase 14 (MMP-14)-mediated cancer cell migration. The J biol chem. 2011;286:33167–77.

    Article  CAS  Google Scholar 

  31. McGowan PM, Duffy MJ. Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database. Ann Oncol. 2008;19:1566–72.

    Article  CAS  Google Scholar 

  32. Wu K, Yang Q, Liu Y, Wu A, Yang Z. Meta-analysis on the association between pathologic complete response and triple-negative breast cancer after neoadjuvant chemotherapy. World J Surg Oncol. 2014;12:95.

    Article  Google Scholar 

  33. Itoh Y, Seiki M. MT1-MMP: a potent modifier of pericellular microenvironment. J Cell Physiol. 2006;206:1–8.

    Article  CAS  Google Scholar 

  34. Alcantara MB, Dass CR. Regulation of MT1-MMP and MMP-2 by the serpin PEDF: a promising new target for metastatic cancer. Cell Physiol Biochem. 2013;31:487–94.

    Article  CAS  Google Scholar 

  35. Atkinson JM, Pennington CJ, Martin SW, Anikin VA, Mearns AJ, Loadman PM, et al. Membrane type matrix metalloproteinases (MMPs) show differential expression in non-small cell lung cancer (NSCLC) compared to normal lung: correlation of MMP-14 mRNA expression and proteolytic activity. Eur J Cancer. 2007;43:1764–71.

    Article  CAS  Google Scholar 

  36. Udayakumar TS, Chen ML, Bair EL, Von Bredow DC, Cress AE, Nagle RB, et al. Membrane type-1-matrix metalloproteinase expressed by prostate carcinoma cells cleaves human laminin-5 beta3 chain and induces cell migration. Cancer Res. 2003;63:2292–9.

    CAS  PubMed  Google Scholar 

  37. Okada A, Bellocq JP, Rouyer N, Chenard MP, Rio MC, Chambon P, et al. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci U S A. 1995;92:2730–4.

    Article  CAS  Google Scholar 

  38. Munaut C, Noel A, Hougrand O, Foidart JM, Boniver J, Deprez M. Vascular endothelial growth factor expression correlates with matrix metalloproteinases MT1-MMP, MMP-2 and MMP-9 in human glioblastomas. IntJ Cancer. 2003;106:848–55.

    Article  CAS  Google Scholar 

  39. Sabeh F, Li XY, Saunders TL, Rowe RG, Weiss SJ. Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion. J Biol Chem. 2009;284:23001–11.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

We would like to acknowledge the reviewers for their helpful comments on this paper.

Conflicts of interest

This study complies with the current laws of China.

Author information

Authors and Affiliations

  1. Cancer Center, Heyuan People’s hospital, Heyuan, Guangdong, 517000, China

    Kun-peng Wu

  2. Cancer Center, Jining No.1 People’s Hospital, Jining, Shandong, 272011, China

    Qiang Li

  3. Department of Urology, The Third People’s Hospital, Guangzhou Medical University, Huizhou, Guangdong, 516002, China

    Fu-xiang Lin & Wei Li

  4. Department of Economic Management, Military General Hospital of Beijing PLA, Beijing, 100700, China

    Jun Li

  5. Department of Ophthalmology, Heyuan People’s Hospital, Heyuan, Guangdong, 517000, China

    Lu-min Wu

  6. Department of Gynaecology and Obstetrics, Women and Child Care Institute of Heyuan, Heyuan, Guangdong, 517000, China

    Qiao-zhu Yang

Authors
  1. Kun-peng Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qiang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fu-xiang Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jun Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lu-min Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Qiao-zhu Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Kun-peng Wu or Qiao-zhu Yang.

Additional information

Kun-peng Wu, Qiang Li, and Fu-xiang Lin are co-first authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, Kp., Li, Q., Lin, Fx. et al. MT1-MMP is not a good prognosticator of cancer survival: evidence from 11 studies. Tumor Biol. 35, 12489–12495 (2014). https://doi.org/10.1007/s13277-014-2567-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-014-2567-8

Keywords

Search

Navigation