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Role of IL-17F T7488C polymorphism in carcinogenesis: a meta-analysis

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Tumor Biology

Abstract

Previous case-control studies on the association of interleukin-17F (IL-17F) T7488C polymorphism and cancer risk have yielded conflicting and inconclusive findings. We performed a meta-analysis by pooling all currently available data to acquire a more precise estimation of the association. A comprehensive literature screening from the PubMed, Embase, Web of Science, and Wanfang databases was performed for eligible publications without language restrictions. The pooled odds ratios (ORs) with corresponding 95 % confidence intervals (95 % CIs) were calculated. According to the inclusion criteria, a total of nine case-control studies with 3,034 cases and 3,694 controls were included. Overall, the pooled ORs showed that IL-17F T7488C polymorphism was associated with neither increased nor decreased risk of cancer. However, the IL-17F T7488C polymorphism exerted risk effect on cancer in population-based case-control studies when stratifying analysis by source of controls (C vs T OR = 1.24, 95 % CI, 1.10–1.40, pooled OR (POR) < 0.001; TC vs TT OR = 1.28, 95 % CI, 1.11–1.48, POR = 0.001; CC + TC vs TT OR = 1.29, 95 % CI, 1.12–1.48, POR < 0.001). Additionally, the variant genotypes of IL-17F T7488C could alter the risk of gastric cancer under the following comparisons (C vs T OR = 1.29, 95 % CI, 1.13–1.47, POR < 0.001; TC vs TT OR = 1.35, 95 % CI, 1.14–1.60, POR < 0.001; CC + TC vs TT OR = 1.35, 95 % CI, 1.15–1.58, POR < 0.001). Sensitivity analysis by sequential omission of single study did not materially alter the pooled findings. The present meta-analysis suggests that the IL-17F T7488C polymorphism may modify the risk of cancer, particularly gastric cancer. However, the precise association needs to be elucidated by more individual studies with sufficient statistical power.

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References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.

    Article  PubMed  Google Scholar 

  2. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357:539–45.

    Article  CAS  PubMed  Google Scholar 

  3. Wang K, Grivennikov SI, Karin M. Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases. Ann Rheum Dis. 2013;72 Suppl 2:ii100–3.

    CAS  PubMed  Google Scholar 

  4. Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 2012;491:254–8.

    PubMed Central  CAS  PubMed  Google Scholar 

  5. Amedei A, Munari F, Bella CD, Niccolai E, Benagiano M, Bencini L, et al. Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma. Intern Emerg Med. 2014;9:303–9.

    Article  PubMed  Google Scholar 

  6. Straus DS. TNFalpha and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. Mol Cancer. 2013;12:78.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Liao R, Sun J, Wu H, Yi Y, Wang JX, He HW, et al. High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma. J Exp Clin Cancer Res. 2013;32:3.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Zarogoulidis P, Katsikogianni F, Tsiouda T, Sakkas A, Katsikogiannis N, Zarogoulidis K. Interleukin-8 and interleukin-17 for cancer. Cancer Invest. 2014.

  9. Hizawa N, Kawaguchi M, Huang SK, Nishimura M. Role of interleukin-17F in chronic inflammatory and allergic lung disease. Clin Exp Allergy. 2006;36:1109–14.

    Article  CAS  PubMed  Google Scholar 

  10. Song X, Qian Y. IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases. Cell Signal. 2013;25:2335–47.

    Article  CAS  PubMed  Google Scholar 

  11. Qinghai Z, Yanying W, Yunfang C, Xukui Z, Xiaoqiao Z. Effect of interleukin-17A and interleukin-17F gene polymorphisms on the risk of gastric cancer in a Chinese population. Gene. 2014;537:328–32.

    Article  PubMed  Google Scholar 

  12. Wu X, Zeng Z, Chen B, Yu J, Xue L, Hao Y, et al. Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. Int J Cancer. 2010;127:86–92.

    Article  CAS  PubMed  Google Scholar 

  13. Shibata T, Tahara T, Hirata I, Arisawa T. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. Hum Immunol. 2009;70:547–51.

    Article  CAS  PubMed  Google Scholar 

  14. Omrane I, Baroudi O, Bougatef K, Mezlini A, Abidi A, Medimegh I, et al. Significant association between IL23R and IL17F polymorphisms and clinical features of colorectal cancer. Immunol Lett. 2014;158:189–94.

    Article  CAS  PubMed  Google Scholar 

  15. Kaabachi W, ben Amor A, Kaabachi S, Rafrafi A, Tizaoui K, Hamzaoui K. Interleukin-17A and -17F genes polymorphisms in lung cancer. Cytokine. 2014;66:23–9.

    Article  CAS  PubMed  Google Scholar 

  16. Zhou B, Zhang P, Wang Y, Shi S, Zhang K, Liao H, et al. Interleukin-17 gene polymorphisms are associated with bladder cancer in a Chinese Han population. Mol Carcinog. 2013;52:871–8.

    Article  CAS  PubMed  Google Scholar 

  17. Wang L, Jiang Y, Zhang Y, Wang Y, Huang S, Wang Z, et al. Association analysis of IL-17A and IL-17F polymorphisms in Chinese Han women with breast cancer. PLoS One. 2012;7:e34400.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Ruan Y, Hu YZ, Tao K, Zhang R. Association analysis of IL-17A and IL-17F gene polymorphism with epithelial ovarian cancer. J Hunan Normal Univ. 2012;9:21–4 [Article in Chinese].

    Google Scholar 

  19. Quan Y, Zhou B, Wang Y, Duan R, Wang K, Gao Q, et al. Association between IL17 polymorphisms and risk of cervical cancer in Chinese women. Clin Dev Immunol. 2012;2012:258293.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Cochran WG. The comparison of percentages in matched samples. Biometrika. 1950;37:256–66.

    Article  CAS  PubMed  Google Scholar 

  21. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    CAS  PubMed  Google Scholar 

  23. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  CAS  PubMed  Google Scholar 

  24. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Stuck AE, Rubenstein LZ, Wieland D. Bias in meta-analysis detected by a simple, graphical test. Asymmetry detected in funnel plot was probably due to true heterogeneity. BMJ. 1998;316:469. author reply 470-461.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  26. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 cells. Annu Rev Immunol. 2009;27:485–517.

    Article  CAS  PubMed  Google Scholar 

  27. Shime H, Yabu M, Akazawa T, Kodama K, Matsumoto M, Seya T, et al. Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. J Immunol. 2008;180:7175–83.

    Article  CAS  PubMed  Google Scholar 

  28. Lan C, Huang X, Lin S, Huang H, Cai Q, Lu J, et al. High density of IL-17-producing cells is associated with improved prognosis for advanced epithelial ovarian cancer. Cell Tissue Res. 2013;352:351–9.

    Article  CAS  PubMed  Google Scholar 

  29. Li J, Lau G, Chen L, Yuan YF, Huang J, Luk JM, et al. Interleukin 23 promotes hepatocellular carcinoma metastasis via NF-kappa B induced matrix metalloproteinase 9 expression. PLoS One. 2012;7:e46264.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  30. Arisawa T, Tahara T, Shiroeda H, Matsue Y, Minato T, Nomura T, et al. Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3′-UTR, influence susceptibility to gastric cancer. Hum Immunol. 2012;73:747–52.

    Article  CAS  PubMed  Google Scholar 

  31. Siakavellas SI, Bamias G. Role of the IL-23/IL-17 axis in Crohn’s disease. Discov Med. 2012;14:253–62.

    PubMed  Google Scholar 

  32. Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang SK. IL-17 cytokine family. J Allergy Clin Immunol. 2004;114:1265–73. quiz 1274.

    Article  CAS  PubMed  Google Scholar 

  33. Abhimanyu, Bose M, Komal, Varma-Basil M. Lack of association between IL17A and IL17F polymorphisms and related serum levels in north Indians with tuberculosis. Gene. 2013;529:195–8.

    Article  CAS  PubMed  Google Scholar 

  34. Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, et al. Genetic polymorphisms of molecules associated with inflammation and immune response in Japanese subjects with functional dyspepsia. Int J Mol Med. 2007;20:717–23.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Anesthesiology, Fourth Affiliated Hospital of Nantong University, First Hospital of Yancheng, Yancheng, 224001, Jiangsu Province, China

    Fen Yao, Jianye Bai, Feng Li & Bin Qian

  2. Department of Surgical Oncology, Eighty-first Hospital of People’s Liberation Army, Nanjing, 210002, Jiangsu Province, China

    Shushan Yan

  3. Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China

    Xiaochen Wang & Beicheng Sun

  4. Department of Chest Surgery, Fourth Affiliated Hospital of Nantong University, First Hospital of Yancheng, Yancheng, 224001, Jiangsu Province, China

    Denghui Shi

  5. Department of Neurosurgery, Fourth Affiliated Hospital of Nantong University, First Hospital of Yancheng, Yancheng, 224001, Jiangsu Province, China

    Bin Qian

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  1. Fen Yao
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  2. Shushan Yan
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  3. Xiaochen Wang
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  4. Denghui Shi
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  5. Jianye Bai
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  6. Feng Li
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  7. Beicheng Sun
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  8. Bin Qian
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Corresponding authors

Correspondence to Beicheng Sun or Bin Qian.

Additional information

Fen Yao, Shushan Yan, and Xiaochen Wang contributed equally to this work.

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Yao, F., Yan, S., Wang, X. et al. Role of IL-17F T7488C polymorphism in carcinogenesis: a meta-analysis. Tumor Biol. 35, 9061–9068 (2014). https://doi.org/10.1007/s13277-014-2171-y

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  • DOI: https://doi.org/10.1007/s13277-014-2171-y

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