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miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7

  • Research Article
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Tumor Biology

Abstract

Accumulating evidence shows that microRNAs (miRNAs) are involved in the development and progression of multiple tumors, including hepatocellular carcinoma (HCC). Recent studies have found that miR-24 acts as an oncogene in several tumors; however, the function of miR-24 in HCC remains unclear. In this study, we found that miR-24 was increased in HCC tissues and cell lines. Inhibition of miR-24 by inhibitor significantly suppressed HCC cells proliferation, migration, and invasion. Furthermore, the sex-determining region Y (SRY)-box 7 (SOX7), a putative tumor suppressor, was found to be a target of miR-24 in HCC cells. Forced expression of SOX7 substantially attenuated the oncogenic effects of miR-24. Those results strongly suggest that miR-24 plays important role in HCC development partially by targeting SOX7.

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Authors and Affiliations

  1. Departments of Transplant Surgery, the Third Affiliated Hospital, Central South University, Hunan, China

    Ying Ma, Xing-guo She, Ying-zi Ming & Qi-quan Wan

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  1. Ying Ma
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  2. Xing-guo She
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  3. Ying-zi Ming
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Correspondence to Xing-guo She.

Additional information

Ying Ma and Xing-guo She contributed equally to this work.

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Ma, Y., She, Xg., Ming, Yz. et al. miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7. Tumor Biol. 35, 10731–10736 (2014). https://doi.org/10.1007/s13277-014-2018-6

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  • DOI: https://doi.org/10.1007/s13277-014-2018-6

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