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LRG1 is an independent prognostic factor for endometrial carcinoma

  • Research Article
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Tumor Biology

Abstract

Endometrial cancer (EC) is one of the most common female malignancies. The patients with high-risk factors may have poor prognosis. Therefore, there is an urgent need to find a new molecule to more accurately predict survival of patients. Leucine-rich-alpha-2-glycoprotein1 (LRG1), one of leucine-rich repeat family, was closely associated with cancer metastasis and poor prognosis. The biological functions and the expression level of LRG1 remain obscure in EC. In this study, by immunohistochemical analysis of 242 EC patient tissues, we found that LRG1 expression was associated with stage and lymphatic metastasis in both test cohort (133 patients) and validation cohort (109 patients). Furthermore, to investigate the prognostic value of LRG1 in endometrial carcinoma, we analyzed the correlation between variables and overall survival with Cox proportional hazard regression. The result showed that LRG1 was an independent prognostic factor for overall survival of endometrial carcinoma patients. To further evaluate the prognostic efficiency of LRG1 in endometrial carcinoma, we compared the sensitivity and specificity of LRG1 in endometrial carcinoma prognosis by logistic regression. The result showed that LRG1 combining with other clinicopathological risk factors was a stronger prognostic model than clinicopathological risk factors alone or their combination. Thus, LRG1 potentially offered clinical value in directing personal treatment for endometrial carcinoma patients.

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Acknowledgments

This work was supported by the National Science Foundation of China (no. 81372794), Science and Technology Commission of Shanghai Municipality(13JC1404502),Songjiang District of Science and Technology Commission of Shanghai Municipality (no. 10SJGG26), and Shanghai Songjiang District Central Hospital (no. BY10A07).

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yisan Road, Shanghai, 200233, People’s Republic of China

    Shan-Yun Wen, Li Ma, Qiu-Lin Ge, Xiao-Lu Zhu, Wei Xu, Wen-Jing Ding, Bing-Qing Yang & Yin-Cheng Teng

  2. Department of Obstetrics and Gynecology, Shanghai Songjiang District Central Hospital, Shanghai, People’s Republic of China

    Shan-Yun Wen

  3. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Room 428, Wenxuan Building of Medicine, 800 Dongchuan Road, Shanghai, 200240, People’s Republic of China

    Shan-Yun Wen, Xiao-Mei Yang, Yan-Li Zhang, Shu-Heng Jiang & Zhi-Gang Zhang

  4. Department of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital of the China Welfare Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China

    Shan-Yun Wen

  5. Department of Biostatistics, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China

    Li-Na Zhang

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  1. Shan-Yun Wen
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  2. Li-Na Zhang
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  4. Yan-Li Zhang
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  5. Li Ma
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  8. Xiao-Lu Zhu
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  9. Wei Xu
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  10. Wen-Jing Ding
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  11. Bing-Qing Yang
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  12. Zhi-Gang Zhang
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Corresponding authors

Correspondence to Zhi-Gang Zhang or Yin-Cheng Teng.

Additional information

Shan-Yun Wen and Li-Na Zhang contributed equally to this work.

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Wen, SY., Zhang, LN., Yang, XM. et al. LRG1 is an independent prognostic factor for endometrial carcinoma. Tumor Biol. 35, 7125–7133 (2014). https://doi.org/10.1007/s13277-014-1953-6

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  • DOI: https://doi.org/10.1007/s13277-014-1953-6

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