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RETRACTED ARTICLE: Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis

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Tumor Biology

This article was retracted on 17 August 2015

Abstract

We conducted a meta-analysis in order to investigate the relationships between PTEN gene mutations and the prognosis in glioma. The following electronic databases were searched for relevant articles without any language restrictions: Web of Science (1945 ~ 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013). Meta-analyses were conducted using the STATA software (Version 12.0, Stata Corporation, College Station, Texas USA). Hazard ratio (HR) with its corresponding 95 % confidence interval (95%CI) was calculated. Six independent cohort studies with a total of 357 glioma patients met our inclusion criteria. Our meta-analysis results indicated that glioma patients with PTEN gene mutations exhibited a significantly shorter overall survival (OS) than those without PTEN gene mutations (HR = 3.66, 95%CI = 2.02 ~ 5.30, P < 0.001). Ethnicity-stratified subgroup analysis demonstrated that PTEN gene mutations were closely linked to poor prognosis in glioma among Americans (HR = 3.72, 95%CI = 1.72 ~ 5.73, P < 0.001), while similar correlations were not observed among populations in Sweden, Italy, and Malaysia (all P > 0.05). Our meta-analysis provides direct and strong evidences for the speculation of PTEN gene mutations’ correlation with poor prognosis of glioma patients.

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Acknowledgments

We would like to acknowledge the reviewers for their helpful comments on this paper.

Conflicts of interest

The authors have declared that no competing interests exist.

Author information

Authors and Affiliations

  1. Department of Neurology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of China

    Wei-Zhong Xiao

  2. Department of Neurosurgery, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of China

    Dong-Hua Han

  3. Department of Neurosurgery, Tongji hospital, Tongji University, Xincun Road No. 389, Putuo District, Shanghai, 200065, People’s Republic of China

    Fei Wang, You-Hou Zhu, Yi-Fang Wu & Ning-Tao Liu

  4. Department of Neurosurgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201399, People’s Republic of China

    Yong-Qian Wang

  5. Department of Neurosurgery, Wuxi Second Hospital Affiliated to Nanjing Medical University, Wuxi, 214002, People’s Republic of China

    Ji-Yong Sun

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  1. Wei-Zhong Xiao
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  2. Dong-Hua Han
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  3. Fei Wang
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Corresponding author

Correspondence to Fei Wang.

Additional information

Wei-Zhong Xiao and Dong-Hua Han are co-first authors.

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Xiao, WZ., Han, DH., Wang, F. et al. RETRACTED ARTICLE: Relationships between PTEN gene mutations and prognosis in glioma: a meta-analysis. Tumor Biol. 35, 6687–6693 (2014). https://doi.org/10.1007/s13277-014-1885-1

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  • DOI: https://doi.org/10.1007/s13277-014-1885-1

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