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Propofol induces endoplasmic reticulum (ER) stress and apoptosis in lung cancer cell H460

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Tumor Biology

Abstract

Propofol is one of the most commonly used intravenous anesthetic agents during cancer resection surgery. It can influence proliferation, motility, and invasiveness of cancer cells in vitro and in vivo. However, the role of the propofol in the lung cancer cells remains unclear. In this study, we demonstrated the effects of propofol on the proliferation and the apoptosis of lung cancer cell H460 by using colony formation assay and flow cytometry. Propofol also decreased tumor size and weight in established xenografted tumors. Furthermore, propofol-induced endoplasmic reticulum (ER) stress was determined by Western blot.

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Acknowledgments

We thank Dr. Dao-Song Dong for his valuable comments and excellent technical assistance.

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Authors and Affiliations

  1. Department of Anaesthesiology, The First Hospital of China Medical University, Shenyang City, Liaoning Province, 110001, People’s Republic of China

    Wen-Yao Cui, Yan Liu, Yong-Qiang Zhu, Tao Song & Qiu-Shi Wang

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  1. Wen-Yao Cui
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  2. Yan Liu
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  3. Yong-Qiang Zhu
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  4. Tao Song
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  5. Qiu-Shi Wang
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Correspondence to Wen-Yao Cui.

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Cui, WY., Liu, Y., Zhu, YQ. et al. Propofol induces endoplasmic reticulum (ER) stress and apoptosis in lung cancer cell H460. Tumor Biol. 35, 5213–5217 (2014). https://doi.org/10.1007/s13277-014-1677-7

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  • DOI: https://doi.org/10.1007/s13277-014-1677-7

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