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Upregulation of SCC-S2 in immune cells and tumor tissues of papillary thyroid carcinoma

  • Research Article
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Tumor Biology

Abstract

Studies have shown that SCC-S2 can be detected in cancer cells, but its relation with thyroid cancer remains uncertain. In the current study, we investigated SCC-S2 expression in thyroid cancer from the immune cell perspective and tumor tissue perspective. Levels of SCC-S2 in CD4+ T cells, CD8+ T cells, monocytes, natural killer (NK) T cells, tumor tissues, and adjacent noncancerous thyroid tissues were tested by real-time reverse transcription PCR and Western blot. Results revealed that mRNA and protein levels of SCC-S2 were significantly increased in peripheral CD4+ (mRNA, 1.90-fold; protein, 1.55-fold) and CD8+ T cells (mRNA, 2.37-fold; protein, 1.72-fold) but not monocytes and NKT cells in patients than in healthy donors. Further elevated mRNA level but not protein expression was observed in tumor-infiltrating CD4+ T cells, whereas both mRNA level and protein expression were further increased in tumor-infiltrating CD8+ T cells. Also, mRNA and protein levels of SCC-S2 in thyroid tissues were significantly elevated than those in adjacent noncancerous thyroid tissues. Moreover, patients with cervical lymph node metastasis presented clearly higher mRNA and protein expression of SCC-S2 compared to those without cervical lymph node metastasis (p < 0.05). These results suggest that SCC-S2 may play roles in affecting both immune cells and tumor cells in the thyroid and may indicate a novel pathway for understanding the pathogenesis of the disease.

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Acknowledgements

We thank Lingcheng Wang, Yinghua Song, and Xuelin Men for their great contributions in directing experiments and writing paper.

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Authors and Affiliations

  1. Department of Nuclear Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuan Jia Gang, Chongqing, 400016, China

    Dong Duan, Yu-Quan Zhu, Li-Li Guan & Jie Wang

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  1. Dong Duan
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  2. Yu-Quan Zhu
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  3. Li-Li Guan
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Correspondence to Dong Duan.

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Duan, D., Zhu, YQ., Guan, LL. et al. Upregulation of SCC-S2 in immune cells and tumor tissues of papillary thyroid carcinoma. Tumor Biol. 35, 4331–4337 (2014). https://doi.org/10.1007/s13277-013-1568-3

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  • DOI: https://doi.org/10.1007/s13277-013-1568-3

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