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The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population

  • Research Article
  • Published:
Tumor Biology

Abstract

To investigate the association between gastric cardiac adenocarcinoma (GCA) and six functional single nucleotide polymorphisms (SNPs) including interleukin 1A (IL1A) rs1800587 C>T, IL1B rs16944 G>A, IL1f7 rs3811047 G>A, IL3 rs40401 C>T, IL3 rs2073506 G>A, and IL7Rα rs6897932 A>G. We performed a hospital-based case–control study to evaluate the genetic effects of these SNPs. A total of 243 GCA cases and 476 controls were enrolled in this study. A custom-by-design 48-Plex SNPscanTM kit was used to determine the genotypes. The IL1f7 rs3811047 G>A polymorphism was significantly associated with a decreased risk of GCA either in the single locus analyses or the recessive genetic model. However, there was no significant association between the other five SNPs and GCA risk. These results elucidated that the functional polymorphism, IL1f7 rs3811047 G>A, might contribute to GCA susceptibility. However, the statistical power of our study was limited, large well-designed studies and further functional investigations are needed to confirm our findings.

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Abbreviations

CI:

Confidential interval

GCA:

Gastric cardiac adenocarcinoma

IL7Rα :

Interleukin 7 receptor alpha

OR:

Odds ratio

SNPs:

Single nucleotide polymorphisms

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Acknowledgments

We wish to thank Dr. Da Ding and Dr. Yan Liu (Genesky Biotechnologies Inc., Shanghai, China) for technical support.

Grant support

This study was supported in part by National Natural Science Foundation of China (81370001, 81371927, 81101889, 81000028), Jiangsu Province Natural Science Foundation (BK2010333, BK2011481), Social Development Foundation of Zhenjiang (SH2010017), Changzhou Young Talents and Science-Technology Foundation of Health Bureau (QN201102), Affiliated People’s Hospital of Jiangsu University fund (Y200913) and Jiangsu University Clinical medicine science and technology development fund (JLY20120004).

Condensed abstract

We performed a hospital-based case–control study to evaluate the genetic effects of six SNPs including interleukin 1A (IL1A) rs1800587 C>T, IL1B rs16944 G>A, IL1f7 rs3811047 G>A, IL3 rs40401 C>T, IL3 rs2073506 G>A, and IL7Rα rs6897932 A>G on the development of GCA. Our results demonstrated that functional variant IL1f7 rs3811047 G>A might contribute to GCA susceptibility.

Conflicts of interest

We declare that we have no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212002, China

    Xu Wang, Jun Yin, Yijun Shi, Weifeng Tang, Guowen Ding, Chao Liu, Suocheng Chen & Haiyong Gu

  2. Department of Cardiothoracic Surgery, The First People’s Hospital of Changzhou and The Third Affiliated Hospital of Suzhou University, Changzhou, 213003, China

    Liang Zheng

  3. Cancer institute, Department of chemotherapy, People’s Hospital Affiliated to Jiangsu University, Zhenjiang, Jiangsu, 212002, China

    Liming Wang

  4. Department of Orthopedics, Affiliated Hospital of Nanjing Medical University, Changzhou Second People’s Hospital, Changzhou, 213003, China

    Ruiping Liu

  5. Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212000, China

    Haiyong Gu

Authors
  1. Xu Wang
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  2. Jun Yin
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  3. Liang Zheng
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  4. Liming Wang
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  5. Yijun Shi
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  6. Weifeng Tang
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  7. Guowen Ding
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  8. Chao Liu
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  9. Ruiping Liu
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  10. Suocheng Chen
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  11. Haiyong Gu
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Corresponding authors

Correspondence to Suocheng Chen or Haiyong Gu.

Additional information

Xu Wang and Jun Yin contributed equally to this work.

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Wang, X., Yin, J., Zheng, L. et al. The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population. Tumor Biol. 35, 3509–3515 (2014). https://doi.org/10.1007/s13277-013-1463-y

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  • DOI: https://doi.org/10.1007/s13277-013-1463-y

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