Skip to main content

Advertisement

SpringerLink
Log in

An updated meta-analysis of transforming growth factor-β1 gene: three polymorphisms with gastric cancer

  • Review
  • Published:
Tumor Biology

Abstract

To derive a more precise estimation of the relationship between TGF-β1 polymorphisms and gastric cancer (GC) risk, we conducted a meta-analysis of all available case–control studies relating the C-509 T, T869C, and G 915C polymorphisms of the TGF-β1 gene to the risk of developing GC. The effect summary odds ratio (OR) and 95 % confidence intervals (CIs) were obtained. Funnel plots and Egger's test were used to estimate publication bias. Finally, 11 studies were included in the final meta-analysis. With respect to C-509 T polymorphism, it was found that significantly increased GC risk was associated with the TT genotype in the recessive genetic model in overall analysis (TT vs. CC + CT: OR = 1.23, 95 % CI 1.09–1.38, P heterogeneity = 0.13) and in Asian population (TT vs. CC + CT: OR = 1.24, 95 % CI 1.10–1.39, P heterogeneity = 0.18). With respect to T869C and G915C polymorphisms, no significant association with GC risk was demonstrated in overall analysis and subgroup analyses according to ethnicity for all genetic models. This meta-analysis suggested that the T allele of TGF-β1 509C/T polymorphism is probably the susceptibility factor for GC.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127:2893–917.

    Article  PubMed  CAS  Google Scholar 

  2. Crew KD, Neugut AI. Epidemiology of gastric cancer. World J Gastroenterol. 2006;12:354–62.

    PubMed  Google Scholar 

  3. Lin Y, Ueda J, Kikuchi S, et al. Comparative epidemiology of gastric cancer between Japan and China. World J Gastroenterol. 2011;17:4421–8.

    Article  PubMed Central  PubMed  Google Scholar 

  4. Yin M, Hu Z, Tan D, et al. Molecular epidemiology of genetic susceptibility to gastric cancer: focus on single nucleotide polymorphisms in gastric carcinogenesis. Am J Transl Res. 2009;1:44–54.

    PubMed Central  PubMed  CAS  Google Scholar 

  5. Gao L, Weck MN, Nieters A, et al. Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany. Eur J Cancer. 2009;45:428–34.

    Article  PubMed  CAS  Google Scholar 

  6. Saeki N, Ono H, Sakamoto H, et al. Genetic factors related to gastric cancer susceptibility identified using a genome-wide association study. Cancer Sci. 2013;104:1–8.

    Article  PubMed  CAS  Google Scholar 

  7. Chen B, Cao L, Zhou Y, et al. Glutathione S-transferase T1 (GSTT1) gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiologic studies. Dig Dis Sci. 2010;55:1831–8.

    Article  PubMed  CAS  Google Scholar 

  8. Persson C, Canedo P, Machado JC, et al. Polymorphisms in inflammatory response genes and their association with gastric cancer: a HuGE systematic review and meta-analyses. Am J Epidemiol. 2011;173:259–70.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Loh M, Koh KX, Yeo BH, et al. Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race. Eur J Cancer. 2009;45:2562–8.

    Article  PubMed  CAS  Google Scholar 

  10. Geng J, Zhang YW, Huang GC, et al. XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: a meta-analysis. World J Gastroenterol. 2008;14:6733–7.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  11. Dong J, Dai J, Zhang M, et al. Potentially functional COX-2-1195G > A polymorphism increases the risk of digestive system cancers: a meta-analysis. J Gastroenterol Hepatol. 2010;25:1042–50.

    Article  PubMed  CAS  Google Scholar 

  12. Ebert MP, Yu J, Miehlke S, et al. Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer. Br J Cancer. 2000;82:1795–800.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  13. Suda A, Saito N, Seshimo A, et al. Examination of transforming growth factor beta1 expression in the serum and tumor tissue of gastric cancer. Int Surg. 2009;94:182–8.

    PubMed  Google Scholar 

  14. Ananiev J, Gulubova MV, Manolova IM. Prognostic significance of CD83 positive tumor-infiltrating dendritic cells and expression of TGF-beta 1 in human gastric cancer. Hepatogastroenterology. 2011;58:1834–40.

    PubMed  CAS  Google Scholar 

  15. Ananiev J, Gulubova M, Tchernev G, et al. Relation between transforming growth factor-β1 expression, its receptor and clinicopathological factors and survival in HER2-negative gastric cancers. Wien Klin Wochenschr. 2011;123:668–73.

    Article  PubMed  CAS  Google Scholar 

  16. Grainger DJ, Heathcote K, Chiano M, et al. Genetic control of the circulating concentration of transforming growth factor type beta1. Hum Mol Genet. 1999;8:93–7.

    Article  PubMed  CAS  Google Scholar 

  17. Awad MR, El-Gamel A, Hasleton P, et al. Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation. Transplantation. 1998;66:1014–20.

    Article  PubMed  CAS  Google Scholar 

  18. Fujii D, Brissenden J, Derynck R, et al. Transforming growth factor-beta gene maps to human chromosome 19 long arm and to mouse chromosome 7. Somat Cell Mol Genet. 1986;12:281–8.

    Article  PubMed  CAS  Google Scholar 

  19. Niu H, Niu Z, Zhang XL, et al. Absence of association between transforming growth factor B1 polymorphisms and gastric cancer: a meta-analysis. DNA Cell Biol. 2012;31:706–12.

    Article  PubMed  CAS  Google Scholar 

  20. Li K, Xia F, Zhang K, et al. Association of a tgf-beta1-509c/t polymorphism with gastric cancer risk: a meta-analysis. Ann Hum Genet. 2013;77:1–8.

    Article  PubMed  CAS  Google Scholar 

  21. Chen B, Zeng ZR, Ke B, et al. The study of the relationship between TGF-β1 509C/T polymorphism and different tcm syndromes of gastric cancer. J Guangzhou Univ Tradit Chin Med. 2011;28:339–43 (In Chinese).

    CAS  Google Scholar 

  22. Lin XD, Li C, Shi Y, et al. Correlation of polymorphism of Nme1-1465 T > C and TGFβ1-509 T > C with genetic susceptibility of gastric carcinoma. Zhonghua Bing Li Xue Za Zhi. 2010;39:681–5 (In Chinese).

    PubMed  CAS  Google Scholar 

  23. Bhayal AC, Prabhakar B, Rao KP, et al. Role of transforming growth factor-β1–509 C/T promoter polymorphism in gastric cancer in south Indian population. Tumour Biol. 2011;32:1049–53.

    Article  PubMed  CAS  Google Scholar 

  24. Guan X, Zhao H, Niu J, et al. The VEGF -634G > C promoter polymorphism is associated with risk of gastric cancer. BMC Gastroenterol. 2009;9:77.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  25. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58.

    Article  PubMed  Google Scholar 

  26. DerSimonian R, Kacker R. Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials. 2007;28:105–14.

    Article  PubMed  Google Scholar 

  27. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    PubMed  CAS  Google Scholar 

  28. Zhou Y, Jin GF, Jiang GJ, et al. Correlations of polymorphisms of TGFB1 and TGFBR2 genes to genetic susceptibility to gastric cancer. Ai Zheng. 2007;26:581–5 (In Chinese).

    PubMed  CAS  Google Scholar 

  29. Garcia-Gonzalez MA, Strunk M, Piazuelo E, et al. TGFB1 gene polymorphisms: their relevance in the susceptibility to Helicobacter pylori-related diseases. Genes Immun. 2006;7:640–6.

    Article  PubMed  CAS  Google Scholar 

  30. García-González MA, Lanas A, Quintero E, et al. Gastric cancer susceptibility is not linked to pro-and anti-inflammatory cytokine gene polymorphisms in whites: a Nationwide Multicenter Study in Spain. Am J Gastroenterol. 2007;102:1878–92.

    Article  PubMed  CAS  Google Scholar 

  31. Jin G, Wang L, Chen W, et al. Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population. Int J Cancer. 2007;120(6):1330–5.

    Article  PubMed  CAS  Google Scholar 

  32. Chen CX, Yu YH, Huang WM. The relationship between transforming growth factor beta 1 gene polymorphism and gastric cancer with helicopter pylori infection. Chin J Gastroenterol Hepatol. 2010;19:202–4 (In Chinese).

    CAS  Google Scholar 

  33. Yu YH, Chen CX, Huang WM, et al. Association of transforming growth factor beta 1 gene polymorphism and gastroauodenal diseases with Helicobacter pylori infection. Chin J Clin Gastroenterol. 2010;22:273–6 (In Chinese).

    CAS  Google Scholar 

  34. Guo W, Dong Z, Guo Y, et al. Polymorphisms of transforming growth factor-β1 associated with increased risk of gastric cardia adenocarcinoma in north China. Int J Immunogenet. 2011;38:215–24.

    Article  PubMed  CAS  Google Scholar 

  35. Zhang P, Di JZ, Zhu ZZ, et al. Association of transforming growth factor-beta 1 polymorphisms with genetic susceptibility to TNM stage I or II gastric cancer. Jpn J Clin Oncol. 2008;38:861–6.

    Article  PubMed  CAS  Google Scholar 

  36. Li T, Cao BW, Dai Y, et al. Correlation of transforming growth factor beta-1 gene polymorphisms C-509 T and T869C and the risk of gastric cancer in China. J Gastroenterol Hepatol. 2008;23:638–42.

    Article  PubMed  CAS  Google Scholar 

  37. Chen CX, Yu YH, Zhang J. Association Between Transforming Growth Factor-beta 1 Gene Polymorphism and Gastric Cancer. Practical Preventive Med. 2010;17:1057–9 (In Chinese).

    CAS  Google Scholar 

  38. Almhanna K, Strosberg J, Malafa M. Targeting AKT protein kinase in gastric cancer. Anticancer Res. 2011;31:4387–92.

    PubMed  CAS  Google Scholar 

  39. Kim K, Chun KH, Suh PG, et al. Alterations in cell proliferation related gene expressions in gastric cancer. Crit Rev Eukaryot Gene Expr. 2011;21:237–54.

    Article  PubMed  CAS  Google Scholar 

  40. Gao L, Nieters A, Brenner H. Meta-analysis: tumour invasion-related genetic polymorphisms and gastric cancer susceptibility. Aliment Pharmacol Ther. 2008;28:565–73.

    Article  PubMed  CAS  Google Scholar 

  41. Jemal A, Siegel R, Ward E, et al. Cancer statistics. CA Cancer J Clin. 2008;58:71–96.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was not supported by any funds. We would like to express our gratitude to the physicians participating in this study. The authors would also like to thank the editors of this manuscript.

Conflicts of interest

None

Author information

Authors and Affiliations

  1. School of Public Health, Wannan Medical College, 241002, Wuhu, Anhui, China

    Wei-wei Chang & Ying-shui Yao

  2. Office of Hospital Infection Management, Wuhu Hospital of traditional Chinese Medicine, 241000, Wuhu, Anhui, China

    Liu Zhang

  3. Epidemiology and Biostatistics School of Public Health, Anhui Medical University, Hefei, 230032, China

    Hong Su

Authors
  1. Wei-wei Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Liu Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hong Su
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ying-shui Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ying-shui Yao.

Additional information

Wei-wei Chang and Liu Zhang contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chang, Ww., Zhang, L., Su, H. et al. An updated meta-analysis of transforming growth factor-β1 gene: three polymorphisms with gastric cancer. Tumor Biol. 35, 2837–2844 (2014). https://doi.org/10.1007/s13277-013-1408-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-013-1408-5

Keywords

Search

Navigation