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TGFβ1 Leu10Pro polymorphism contributes to the development of prostate cancer: evidence from a meta-analysis

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Tumor Biology

Abstract

Transforming growth factor-β1 (TGFβ1) plays a significant role in regulating cellular proliferation and apoptosis. A large number of studies related to the association between TGFβ1 Leu10Pro polymorphism and prostate cancer (PC) risk, but get conflicting results. We performed a meta-analysis based on six studies, assessing the strength of the association using odds ratios (OR) with 95 % confidence intervals (CI). Overall, our evidence has indicated that TGFβ1 Leu10Pro polymorphism had significantly increased PC risk in the allele comparison model (OR = 1.081, 95 % CI = 1.003–1.165, P heterogeneity = 0.141, P = 0.041). In the stratified analysis by ethnicity, the same results were found among Caucasians (for heterozygote model, OR = 1.741, 95 % CI = 1.004–3.020, P heterogeneity = 0.000, P = 0.049; recessive model, OR = 1.339, 95 % CI = 1.045–1.717, P heterogeneity = 0.020, P = 0.021; allele comparison model, OR = 1.091, 95 % CI = 1.005–1.184, P heterogeneity = 0.048, P = 0.037). In conclusion, this meta-analysis suggested that TGFβ1 Leu10Pro polymorphism contributed to the development of PC. A well-designed and larger study is still required to evaluate this polymorphism and PC risk.

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Authors and Affiliations

  1. Department of Urology, the Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, 300211, China

    Qiliang Cai, Yang Tang, Minghao Zhang, Zhiqun Shang, Gang Li, Jing Tian, Ning Jiang, Changyi Quan & Yuanjie Niu

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  1. Qiliang Cai
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  2. Yang Tang
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  3. Minghao Zhang
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  4. Zhiqun Shang
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  5. Gang Li
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  6. Jing Tian
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  7. Ning Jiang
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  8. Changyi Quan
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  9. Yuanjie Niu
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Correspondence to Yuanjie Niu.

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Qiliang Cai and Yang Tang contributed equally to this work.

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Cai, Q., Tang, Y., Zhang, M. et al. TGFβ1 Leu10Pro polymorphism contributes to the development of prostate cancer: evidence from a meta-analysis. Tumor Biol. 35, 667–673 (2014). https://doi.org/10.1007/s13277-013-1092-5

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  • DOI: https://doi.org/10.1007/s13277-013-1092-5

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