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Current evidences on IL1B polymorphisms and lung cancer susceptibility: a meta-analysis

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Tumor Biology

Abstract

Interleukin 1, beta (IL1B) plays a key role in mediating acute and chronic inflammation, which is further correlated with lung carcinogenesis. Several polymorphisms on IL1B gene have been identified, and a series of epidemiological studies have examined the association between IL1B polymorphisms and lung cancer risk. However, these findings are inconclusive. To derive a precise estimation of the relationship, a meta-analysis was performed. We summarized 12 eligible publications on three commonly studied IL1B polymorphisms (i.e., −31 T/C, −511 T/C, and +3954 C/T) by searching electronic databases. Combined odds ratio (OR) with 95 % confidence interval (CI) was calculated to assess the strength of association between them. Heterogeneity and publication bias were also assessed. We observed a significant association between IL1B polymorphisms and lung cancer. For −31T/C, the overall OR (95 % CI) of TT/TC versus CC was 1.23 (1.06–1.43). For +3954 C/T, the overall OR (95 % CI) of CC versus TT and CC versus CT/TT were 0.92 (0.86–0.99) and 0.92 (0.86–0.99), respectively. In conclusion, this meta-analysis suggests that the IL1B −31 T/C and +3954 C/T polymorphisms are associated with lung cancer risk. However, larger number of samples and studies with homogeneous lung cancer patients are needed to confirm these findings.

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References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.

    Article  PubMed  Google Scholar 

  2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10–29.

    Article  PubMed  Google Scholar 

  3. Sant M, Aareleid T, Berrino F, Bielska Lasota M, Carli PM, Faivre J, et al. Eurocare-3: survival of cancer patients diagnosed 1990–94—results and commentary. Ann Oncol. 2003;14 Suppl 5:v61–118.

    Article  PubMed  Google Scholar 

  4. Shi TY, He J, Qiu LX, Zhu ML, Wang MY, Zhou XY, et al. Association between xpf polymorphisms and cancer risk: a meta-analysis. PLoS One. 2012;7:e38606.

    Article  PubMed  CAS  Google Scholar 

  5. Goode EL, Ulrich CM, Potter JD. Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev. 2002;11:1513–30.

    PubMed  CAS  Google Scholar 

  6. Bartsch H, Nair U, Risch A, Rojas M, Wikman H, Alexandrov K. Genetic polymorphism of cyp genes, alone or in combination, as a risk modifier of tobacco-related cancers. Cancer Epidemiol Biomarkers Prev. 2000;9:3–28.

    PubMed  CAS  Google Scholar 

  7. Pliarchopoulou K, Voutsinas G, Papaxoinis G, Florou K, Skondra M, Kostaki K, et al. Correlation of cyp1a1, gstp1 and gstm1 gene polymorphisms and lung cancer risk among smokers. Oncol Lett. 2012;3:1301–6.

    PubMed  CAS  Google Scholar 

  8. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860–7.

    Article  PubMed  CAS  Google Scholar 

  9. Bartsch H, Nair J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch Surg. 2006;391:499–510.

    Article  PubMed  Google Scholar 

  10. Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M, et al. Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers. Am J Physiol Lung Cell Mol Physiol. 2000;278:L906–13.

    PubMed  CAS  Google Scholar 

  11. Boffetta P, Ye W, Boman G, Nyren O. Lung cancer risk in a population-based cohort of patients hospitalized for asthma in Sweden. Eur Respir J. 2002;19:127–33.

    Article  PubMed  CAS  Google Scholar 

  12. Mayne ST, Buenconsejo J, Janerich DT. Previous lung disease and risk of lung cancer among men and women nonsmokers. Am J Epidemiol. 1999;149:13–20.

    Article  PubMed  CAS  Google Scholar 

  13. Bird S, Zou J, Wang T, Munday B, Cunningham C, Secombes CJ. Evolution of interleukin-1beta. Cytokine Growth Factor Rev. 2002;13:483–502.

    Article  PubMed  CAS  Google Scholar 

  14. Dinarello CA. The il-1 family and inflammatory diseases. Clin Exp Rheumatol. 2002;20:S1–13.

    PubMed  CAS  Google Scholar 

  15. Wu KS, Zhou X, Zheng F, Xu XQ, Lin YH, Yang J. Influence of interleukin-1 beta genetic polymorphism, smoking and alcohol drinking on the risk of non-small cell lung cancer. Clin Chim Acta. 2010;411:1441–6.

    Article  PubMed  CAS  Google Scholar 

  16. Campa D, Hung RJ, Mates D, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, et al. Lack of association between polymorphisms in inflammatory genes and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2005;14:538–9.

    Article  PubMed  CAS  Google Scholar 

  17. Lim WY, Chen Y, Ali SM, Chuah KL, Eng P, Leong SS, et al. Polymorphisms in inflammatory pathway genes, host factors and lung cancer risk in Chinese female never-smokers. Carcinogenesis. 2011;32:522–9.

    Article  PubMed  CAS  Google Scholar 

  18. Zienolddiny S, Ryberg D, Maggini V, Skaug V, Canzian F, Haugen A. Polymorphisms of the interleukin-1 beta gene are associated with increased risk of non-small cell lung cancer. Int J Cancer. 2004;109:353–6.

    Article  PubMed  CAS  Google Scholar 

  19. Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y. Il1b rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population. J Thorac Oncol. 2010;5:299–304.

    Article  PubMed  Google Scholar 

  20. Landvik NE, Hart K, Skaug V, Stangeland LB, Haugen A, Zienolddiny S. A specific interleukin-1b haplotype correlates with high levels of il1b mRNA in the lung and increased risk of non-small cell lung cancer. Carcinogenesis. 2009;30:1186–92.

    Article  PubMed  CAS  Google Scholar 

  21. Asada M, Yasuda H, Ebihara S, Tomita N, Suzuki S, Sato M, et al. Interleukin-1beta gene polymorphisms associated with risk of lung cancer in Japanese. Lung Cancer. 2006;54:261–3.

    Article  PubMed  Google Scholar 

  22. Ter-Minassian M, Zhai R, Asomaning K, Su L, Zhou W, Liu G, et al. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis. 2008;29:2147–52.

    Article  PubMed  CAS  Google Scholar 

  23. Vogel U, Christensen J, Wallin H, Friis S, Nexo BA, Raaschou-Nielsen O, et al. Polymorphisms in genes involved in the inflammatory response and interaction with NSAID use or smoking in relation to lung cancer risk in a prospective study. Mutat Res. 2008;639:89–100.

    Article  PubMed  CAS  Google Scholar 

  24. Lee KM, Shen M, Chapman RS, Yeager M, Welch R, He X, et al. Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, China. Carcinogenesis. 2007;28:1437–41.

    Article  PubMed  CAS  Google Scholar 

  25. Truong T, Sauter W, McKay JD, Hosgood 3rd HD, Gallagher C, Amos CI, et al. International lung cancer consortium: coordinated association study of 10 potential lung cancer susceptibility variants. Carcinogenesis. 2010;31:625–33.

    Article  PubMed  CAS  Google Scholar 

  26. Hao M, Wang W, Ye L, Ying X, Liu C, Hu X, et al. Association of genetic polymorphisms within promoter region of TNF-α, IL-1β and IL-10 with the susceptibility to lung cancer. J Environ Occup Med. 2009;26(1):24–7.

    Google Scholar 

  27. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  PubMed  CAS  Google Scholar 

  28. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    PubMed  CAS  Google Scholar 

  29. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.

    Article  PubMed  CAS  Google Scholar 

  30. Van Dyke AL, Cote ML, Wenzlaff AS, Chen W, Abrams J, Land S, et al. Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. Cancer Epidemiol Biomarkers Prev. 2009;18:1829–40.

    Article  PubMed  Google Scholar 

  31. Engels EA, Wu X, Gu J, Dong Q, Liu J, Spitz MR. Systematic evaluation of genetic variants in the inflammation pathway and risk of lung cancer. Cancer Res. 2007;67:6520–7.

    Article  PubMed  CAS  Google Scholar 

  32. Vogel U, Christensen J, Dybdahl M, Friis S, Hansen RD, Wallin H, et al. Prospective study of interaction between alcohol, NSAID use and polymorphisms in genes involved in the inflammatory response in relation to risk of colorectal cancer. Mutat Res. 2007;624:88–100.

    Article  PubMed  CAS  Google Scholar 

  33. Lind H, Zienolddiny S, Ryberg D, Skaug V, Phillips DH, Haugen A. Interleukin 1 receptor antagonist gene polymorphism and risk of lung cancer: a possible interaction with polymorphisms in the interleukin 1 beta gene. Lung Cancer. 2005;50:285–90.

    Article  PubMed  Google Scholar 

  34. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357:539–45.

    Article  PubMed  CAS  Google Scholar 

  35. El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000;404:398–402.

    Article  PubMed  CAS  Google Scholar 

  36. Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup J. A taqi polymorphism in the human interleukin-1 beta (il-1 beta) gene correlates with il-1 beta secretion in vitro. Eur J Clin Invest. 1992;22:396–402.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This work was supported by the Key Program For Anti-cancer Research of Tianjin Municipal Science and Technology Commission (12ZCDZSY15400).

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  1. Department of Lung Cancer, Tianjin Lung Cancer Center, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China

    Chenguang Li & Changli Wang

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  1. Chenguang Li
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  2. Changli Wang
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Correspondence to Changli Wang.

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Li, C., Wang, C. Current evidences on IL1B polymorphisms and lung cancer susceptibility: a meta-analysis. Tumor Biol. 34, 3477–3482 (2013). https://doi.org/10.1007/s13277-013-0925-6

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