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Association between X-ray repair cross-complementation group 1 rs25487 polymorphism and pancreatic cancer risk

  • Research Article
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Tumor Biology

Abstract

Previous published studies suggested that genetic polymorphisms in DNA repair genes could modify the DNA repair capacity and could be associated with pancreatic cancer risk. However, previous studies on the association between X-ray repair cross-complementation group 1 (XRCC1) rs25487 (Arg399Gln) polymorphism and pancreatic cancer risk reported inconsistent results. To obtain a more precise estimation of the association between XRCC1 rs25487 polymorphism and pancreatic cancer risk, we performed a meta-analysis of previous published studies by calculating the pooled odds ratio (OR) with a 95 % confidence interval (95 % CI). Eight individual studies with 5,542 subjects from six publications were finally included into this meta-analysis. The meta-analysis of total eight studies showed that there was no association between XRCC1 rs25487 polymorphism and pancreatic cancer risk in total population under all four genetic models (Gln versus Arg: OR = 1.10, 95 % CI 0.95–1.28, P = 0.199; GlnGln versus ArgArg: OR = 1.15, 95 % CI 0.93–1.41, P = 0.191; GlnGln/ArgGln versus ArgArg: OR = 1.10, 95 % CI 0.97–1.25, P = 0.127; GlnGln versus ArgArg/ArgGln: OR = 1.12, 95 % CI 0.92–1.36, P = 0.253). Subgroup analysis showed that there was no association between XRCC1 rs25487 polymorphism and pancreatic cancer risk in Caucasians, but XRCC1 rs25487 polymorphism was associated with pancreatic cancer risk in Asians (GlnGln/ArgGln versus ArgArg: OR = 1.24, 95 % CI 1.01–1.53, P = 0.040). Therefore, the meta-analysis suggests that XRCC1 rs25487 polymorphism is associated with pancreatic cancer risk in Asians. Further studies with more participants are needed to provide a more precise estimation on the association above.

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References

  1. Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic cancer. Lancet. 2004;363:1049–57.

    Article  PubMed  CAS  Google Scholar 

  2. Heinemann V, Haas M, Boeck S. Systemic treatment of advanced pancreatic cancer. Cancer Treat Rev. 2012;38:843–53.

    Article  PubMed  CAS  Google Scholar 

  3. Hansel DE, Kern SE, Hruban RH. Molecular pathogenesis of pancreatic cancer. Annu Rev Genomics Hum Genet. 2003;4:237–56.

    Article  PubMed  CAS  Google Scholar 

  4. Vaccaro V, Gelibter A, Bria E, Iapicca P, Cappello P, Di Modugno F, et al. Molecular and genetic bases of pancreatic cancer. Curr Drug Targets. 2012;13:731–43.

    Article  PubMed  CAS  Google Scholar 

  5. Aune D et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose–response meta-analysis of prospective studies. Ann Oncol. 2012;23:843–52.

    Article  PubMed  CAS  Google Scholar 

  6. Bracci PM. Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms. Mol Carcinog. 2012;51:53–63.

    Article  PubMed  CAS  Google Scholar 

  7. Yang F, Jin C, Subedi S, Lee CL, Wang Q, Jiang Y, et al. Emerging inorganic nanomaterials for pancreatic cancer diagnosis and treatment. Cancer Treat Rev. 2012;38:566–79.

    Article  PubMed  CAS  Google Scholar 

  8. Almeida KH, Sobol RW. A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair (Amst). 2007;6:695–711.

    Article  CAS  Google Scholar 

  9. Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: utility of current database and implications for human health risk assessment. Mutat Res. 2011;727:1–15.

    Article  PubMed  CAS  Google Scholar 

  10. Tudek B. Base excision repair modulation as a risk factor for human cancers. Mol Aspects Med. 2007;28:258–75.

    Article  PubMed  CAS  Google Scholar 

  11. Horton JK, Watson M, Stefanick DF, Shaughnessy DT, Taylor JA, Wilson SH. XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks. Cell Res. 2008;18:48–63.

    Article  PubMed  CAS  Google Scholar 

  12. Duell EJ, Holly EA, Bracci PM, Wiencke JK, Kelsey KT. A population-based study of the Arg399Gln polymorphism in X-ray repair cross-complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. Cancer Res. 2002;62:4630–6.

    PubMed  CAS  Google Scholar 

  13. Jiao L, Bondy ML, Hassan MM, Wolff RA, Evans DB, Abbruzzese JL, et al. Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. Cancer Detect Prev. 2006;30:284–91.

    Article  PubMed  CAS  Google Scholar 

  14. Wang L, Lin DX, Lu XH, Miao XP, Li H. [Polymorphisms of the DNA repair genes XRCC1 and XPC: relationship to pancreatic cancer risk]. Wei Sheng Yan Jiu. 2006;35:534–6.

    PubMed  Google Scholar 

  15. McWilliams RR, Bamlet WR, Cunningham JM, Goode EL, de Andrade M, Boardman LA, et al. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. Cancer Res. 2008;68:4928–35.

    Article  PubMed  CAS  Google Scholar 

  16. Nakao M, Hosono S, Ito H, Watanabe M, Mizuno N, Sato S, et al. Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese. J Epidemiol. 2012;22:477–83.

    Article  PubMed  Google Scholar 

  17. Yan D, Wang X, Li H, Xu X, Zhu G, He T. Relationship between single nucleotide polymorphism of X-ray repair cross complementing group 1 gene associated with smoking and susceptibility to pancreatic cancer. Chin J Exp Surg. 2012;29:2300–3.

    CAS  Google Scholar 

  18. Cochran WG. The combination of estimates from different experiments. Biometrics. 1954;10:101–29.

    Article  Google Scholar 

  19. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  PubMed  CAS  Google Scholar 

  20. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    PubMed  CAS  Google Scholar 

  21. Mazaki T, Masuda H, Takayama T. Polymorphisms and pancreatic cancer risk: a meta-analysis. Eur J Cancer Prev. 2011;20:169–83.

    Article  PubMed  Google Scholar 

  22. Fan Y, Zhang W, Shi CY, Cai DF. Associations of GSTM1 and GSTT1 polymorphisms with pancreatic cancer risk: evidence from a meta-analysis. Tumour Biol. 2013;34:705–12.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Hepatobiliary Surgery, The Fourth Affiliated Hospital of China Medical University, No.4 Chongshandong Street, Huanggu District, Shenyang, 110032, China

    Honglei Jiang, Dongyan Ma, Guofu Lin, Jian Liang & Junzhe Jin

  2. Infectious Disease Department, Shengjing Hospital of China Medical University, Shenyang, China

    Dan Wu

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  1. Honglei Jiang
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  2. Dan Wu
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  3. Dongyan Ma
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Correspondence to Junzhe Jin.

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Jiang, H., Wu, D., Ma, D. et al. Association between X-ray repair cross-complementation group 1 rs25487 polymorphism and pancreatic cancer risk. Tumor Biol. 34, 3417–3421 (2013). https://doi.org/10.1007/s13277-013-0914-9

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  • DOI: https://doi.org/10.1007/s13277-013-0914-9

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