Skip to main content

Advertisement

SpringerLink
Log in

Myeloperoxidase G463A polymorphism and lung cancer risk in Asians: a pooled analysis

  • Research Article
  • Published:
Tumor Biology

Abstract

Myeloperoxidase (MPO) is an endogenous oxidant enzyme and can generate reactive oxygen species. The MPO G463A polymorphism influences MPO transcription levels and has been proposed to be associated with risk of lung cancer. To assess the effect of MPO G463A polymorphism on lung cancer risk in Asians, a pooled analysis of published case–control studies was performed. PubMed, Embase, China Biomedical Literature, and Wanfang Medicine databases were searched for eligible studies. The strength of the association between MPO G463A polymorphism and lung cancer risk was measured by odds ratio (OR) with 95 % confidence interval (95% CI). Finally, eight studies with a total of 1,679 lung cancer cases and 1,876 non-cancer controls were included. Overall, MPO G463A polymorphism was associated with decreased risk of lung cancer risk in Asians under two genetic models (OR AA vs. GG = 0.58, 95% CI 0.36–0.96, P = 0.033; OR AA vs. GG+AG = 0.60, 95% CI 0.37–0.98, P = 0.040). There was no obvious risk of publication bias in this meta-analysis. In conclusion, the pooled analysis suggests that MPO G463A polymorphism is associated with decreased risk of lung cancer risk in Asians.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.

    Article  PubMed  Google Scholar 

  2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10–29.

    Article  PubMed  Google Scholar 

  3. Herbst RS, Heymach JV, Lippman SM. Lung cancer. N Engl J Med. 2008;359:1367–80.

    Article  CAS  PubMed  Google Scholar 

  4. Brennan P, Hainaut P, Boffetta P. Genetics of lung-cancer susceptibility. Lancet Oncol. 2011;12:399–408.

    Article  CAS  PubMed  Google Scholar 

  5. Chu H, Wang M, Gu D, Wu D, Zhang Z, Tang J. The MPO –463G>A polymorphism and cancer risk: a meta-analysis based on 43 case–control studies. Mutagenesis. 2010;25:389–95.

    Article  CAS  PubMed  Google Scholar 

  6. Zamocky M, Gasselhuber B, Furtmuller PG, Obinger C. Molecular evolution of hydrogen peroxide degrading enzymes. Arch Biochem Biophys. 2012;525:131–44.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Wenten M, Gauderman WJ, Berhane K, Lin PC, Peters J, Gilliland FD. Functional variants in the catalase and myeloperoxidase genes, ambient air pollution, and respiratory-related school absences: an example of epistasis in gene–environment interactions. Am J Epidemiol. 2009;170:1494–501.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Wainstein RV, Wainstein MV, Ribeiro JP, Dornelles LV, Tozzati P, Ashton-Prolla P, et al. Association between myeloperoxidase polymorphisms and its plasma levels with severity of coronary artery disease. Clin Biochem. 2010;43:57–62.

    Article  CAS  PubMed  Google Scholar 

  9. Garrity-Park M, Loftus Jr EV, Sandborn WJ, Smyrk TC. Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and RUNX3 methylation. Inflamm Bowel Dis. 2012;18:275–83.

    Article  PubMed  Google Scholar 

  10. Yuzhalin AE, Kutikhin AG. Inherited variations in the SOD and GPX gene families and cancer risk. Free Radic Res. 2012;46:581–99.

    Article  CAS  PubMed  Google Scholar 

  11. Jiang Z, Zhang Z, Wang Z, Zhang G, Hu K, He B, et al. Association of the 463G-A myeloperoxidase gene polymorphism with gastric cancer risk. Hepatogastroenterology. 2012;59:757–61.

    CAS  PubMed  Google Scholar 

  12. Pabalan N, Jarjanazi H, Sung L, Li H, Ozcelik H. Menopausal status modifies breast cancer risk associated with the myeloperoxidase (MPO) G463A polymorphism in caucasian women: a meta-analysis. PLoS One. 2012;7:e32389.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Lu W, Xing D, Qi J, Tan W, Miao X, Lin D. Genetic polymorphism in myeloperoxidase but not GSTM1 is associated with risk of lung squamous cell carcinoma in a Chinese population. Int J Cancer. 2002;102:275–9.

    Article  CAS  PubMed  Google Scholar 

  14. Wu XM, Zhou YK, Ren S, Hao QL. Gene polymorphism of myeloperoxidase and genetic susceptibility to lung cancer. Ai Zheng. 2003;22:912–5.

    CAS  PubMed  Google Scholar 

  15. Chan EC, Lam SY, Fu KH, Kwong YL. Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: relationship with aberrant promoter methylation of the CDKN2A and RARB genes. Cancer Genet Cytogenet. 2005;162:10–20.

    Article  CAS  PubMed  Google Scholar 

  16. Park JH, Park JM, Kim EJ, Cha SI, Lee EB, Kim CH, et al. Myeloperoxidase −463G>A polymorphism and risk of primary lung cancer in a Korean population. Cancer Detect Prev. 2006;30:257–61.

    Article  CAS  PubMed  Google Scholar 

  17. Yang M, Choi Y, Hwangbo B, Lee JS. Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility. Lung Cancer. 2007;57:135–42.

    Article  PubMed  Google Scholar 

  18. Yoon KA, Kim JH, Gil HJ, Hwang H, Hwangbo B, Lee JS. Cyp1b1, CYP1A1, MPO, and GSTP1 polymorphisms and lung cancer risk in never-smoking Korean women. Lung Cancer. 2008;60:40–6.

    Article  PubMed  Google Scholar 

  19. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  CAS  PubMed  Google Scholar 

  20. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    CAS  PubMed  Google Scholar 

  21. Cochran WG. The combination of estimates from different experiments. Biometrics. 1954;10:101–29.

    Article  Google Scholar 

  22. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Le Marchand L, Seifried A, Lum A, Wilkens LR. Association of the myeloperoxidase −463G–>A polymorphism with lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2000;9:181–4.

    PubMed  Google Scholar 

  24. Zhang TY, Hong XT, Wu YJ, Wu YM. Myeloperoxidase polymorphism in lung cancer patients of Henan Han population. J Zhengzhou Univ (Med Sci). 2006;42:448–50.

    Google Scholar 

  25. Xiao XY, Wang XD, Zang DY. MMP1-1607 1G/2G polymorphism and lung cancer risk: a meta-analysis. Tumour Biol. 2012;33:2385–92.

    Article  CAS  PubMed  Google Scholar 

  26. Hu C, Wang J, Xu Y, Li X, Chen H, Bunjhoo H, et al. Current evidence on the relationship between five polymorphisms in the matrix metalloproteinases (MMP) gene and lung cancer risk: a meta-analysis. Gene. 2013;517:65–71.

    Article  CAS  PubMed  Google Scholar 

  27. Wang S, Zhu J, Zhang R, Gu Z. Association between microsomal epoxide hydrolase 1 T113C polymorphism and susceptibility to lung cancer. Tumour Biol. 2013;34:1045–52.

    Article  CAS  PubMed  Google Scholar 

Download references

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Thoracic Tumor Center, People’s Liberation Army 455 Hospital, 338 West Huaihai Road, Changning District, Shanghai, 200052, China

    Yi-yong Zhou, Shao-ming Zhang, Zhi-gang Cai, Heng Zhang, Lei Wang, Xiao-ping Xu & Hai-bo Wu

Authors
  1. Yi-yong Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shao-ming Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhi-gang Cai
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Heng Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lei Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xiao-ping Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hai-bo Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Shao-ming Zhang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhou, Yy., Zhang, Sm., Cai, Zg. et al. Myeloperoxidase G463A polymorphism and lung cancer risk in Asians: a pooled analysis. Tumor Biol. 34, 3035–3039 (2013). https://doi.org/10.1007/s13277-013-0868-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-013-0868-y

Keywords

Search

Navigation