Skip to main content

Advertisement

SpringerLink
Log in

Association between microsomal epoxide hydrolase 1 polymorphisms and susceptibility to esophageal cancer: a meta-analysis

  • Research Article
  • Published:
Tumor Biology

Abstract

Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in the detoxification of carcinogenic polycyclic aromatic hydrocarbons. EPHX1 Tyr113His and His139Arg polymorphisms have been reported to have some impacts on the EPHX1 activity. Previous case–control studies assessing the associations between EPHX1 polymorphisms and esophageal cancer risk reported conflicting results. To quantitatively summarize the associations of EPHX1 Tyr113His and His139Arg polymorphisms with esophageal cancer risk, a systemic review and meta-analysis of published studies were performed. Published literatures from PubMed, Embase, and China National Knowledge Infrastructure databases were searched. The strength of the associations between EPHX1 polymorphisms and esophageal cancer risk was estimated by the pooled odds ratios (ORs) with its 95 % confidence interval (95 %CI). This meta-analysis yielded nine case–control studies, which included nine studies for Tyr113His polymorphism (1,291 cases and 2,120 controls) and seven studies for His139Arg polymorphism (899 cases and 1,615 controls). Overall, meta-analysis showed that EPHX1 Tyr113His polymorphism was not associated with esophageal cancer risk under all genetic models. Meta-analysis of these seven studies for EPHX1 His139Arg polymorphism showed that EPHX1 His139Arg polymorphism was also not associated with esophageal cancer risk under all genetic models. However, subgroup analysis by ethnicity further showed that there was an obvious association between EPHX1 His139Arg polymorphism and decreased risk of esophageal cancer in Caucasians (ArgArg versus HisArg/HisHis: OR = 0.52, 95 %CI 0.27–0.97, P = 0.041). This meta-analysis suggests that EPHX1 His139Arg polymorphism is associated with decreased risk of esophageal cancer in Caucasians. In addition, more studies with large samples are needed to get a more precise estimation on the associations mentioned above.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Wheeler JB, Reed CE. Epidemiology of esophageal cancer. Surg Clin North Am. 2012;92:1077–87.

    Article  PubMed  Google Scholar 

  2. Pennathur A, Gibson MK, Jobe BA, Luketich JD. Oesophageal carcinoma. Lancet. 2013;381:400–12.

    Article  PubMed  Google Scholar 

  3. Zandberg DP, Bhargava R, Badin S, Cullen KJ. The role of human papillomavirus in nongenital cancers. CA Cancer J Clin. 2013;63:57–81.

    Article  PubMed  Google Scholar 

  4. Denlinger CE, Thompson RK. Molecular basis of esophageal cancer development and progression. Surg Clin North Am. 2012;92:1089–103.

    Article  PubMed  Google Scholar 

  5. Moaven O, Raziee HR, Sima HR, Ganji A, Malekzadeh R, A'Rabi A, et al. Interactions between glutathione-S-transferase M1, T1 and P1 polymorphisms and smoking, and increased susceptibility to esophageal squamous cell carcinoma. Cancer Epidemiol. 2010;34:285–90.

    Article  PubMed  CAS  Google Scholar 

  6. Zhou L, Yuan Q, Yang M. A functional germline variant in the P53 polyadenylation signal and risk of esophageal squamous cell carcinoma. Gene. 2012;506:295–7.

    Article  PubMed  CAS  Google Scholar 

  7. Zhuo W, Zhang L, Wang Y, Zhu B, Chen Z. Cyclin D1 G870a polymorphism is a risk factor for esophageal cancer among Asians. Cancer Invest. 2012;30:630–6.

    Article  PubMed  CAS  Google Scholar 

  8. Puranik YG, Birnbaum AK, Marino SE, Ahmed G, Cloyd JC, Remmel RP, et al. Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy. Pharmacogenomics. 2013;14:35–45.

    Article  PubMed  CAS  Google Scholar 

  9. Wang Q, Pang W, Cui Z, Shi J, Liu Y, Liu B, et al. Upregulation of soluble epoxide hydrolase in proximal tubular cells mediated proteinuria-induced renal damage. Am J Physiol Renal Physiol. 2013;304:F168–176.

    Article  PubMed  CAS  Google Scholar 

  10. Liu F, Yuan D, Wei Y, Wang W, Yan L, Wen T, et al. Systematic review and meta-analysis of the relationship between ephx1 polymorphisms and colorectal cancer risk. PLoS One. 2012;7:e43821.

    Article  PubMed  CAS  Google Scholar 

  11. Nisa H, Budhathoki S, Morita M, Toyomura K, Nagano J, Ohnaka K, Kono S, Ueki T, Tanaka M, Kakeji Y, Maehara Y, Okamura T, Ikejiri K, Futami K, Maekawa T, Yasunami Y, Takenaka K, Ichimiya H, Terasaka R: Microsomal epoxide hydrolase polymorphisms, cigarette smoking, and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study. Mol Carcinog. 2012. doi:10.1002/mc.21897.

  12. Liu H, Li HY, Chen HJ, Huang YJ, Zhang S, Wang J. EPHX1 A139G polymorphism and lung cancer risk: a meta-analysis. Tumour Biol. 2013;34:155–63.

    Article  PubMed  Google Scholar 

  13. Casson AG, Zheng Z, Chiasson D, MacDonald K, Riddell DC, Guernsey JR, et al. Associations between genetic polymorphisms of phase I and II metabolizing enzymes, p53 and susceptibility to esophageal adenocarcinoma. Cancer Detect Prev. 2003;27:139–46.

    Article  PubMed  CAS  Google Scholar 

  14. Lin YC, Wu DC, Lee JM, Hsu HK, Kao EL, Yang CH, et al. The association between microsomal epoxide hydrolase genotypes and esophageal squamous-cell-carcinoma in Taiwan: interaction between areca chewing and smoking. Cancer Lett. 2006;237:281–8.

    Article  PubMed  CAS  Google Scholar 

  15. Jain M, Tilak AR, Upadhyay R, Kumar A, Mittal B. Microsomal epoxide hydrolase (EPHX1), slow (exon 3, 113His) and fast (exon 4, 139Arg) alleles confer susceptibility to squamous cell esophageal cancer. Toxicol Appl Pharmacol. 2008;230:247–51.

    Article  PubMed  CAS  Google Scholar 

  16. Ihsan R, Chattopadhyay I, Phukan R, Mishra AK, Purkayastha J, Sharma J, et al. Role of epoxide hydrolase 1 gene polymorphisms in esophageal cancer in a high-risk area in India. J Gastroenterol Hepatol. 2010;25:1456–62.

    Article  PubMed  CAS  Google Scholar 

  17. Dura P, Bregitha CV, Te Morsche RH, Roelofs HM, Kristinsson JO, Wobbes T, et al. EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians. Oncol Rep. 2012;27:1710–6.

    PubMed  CAS  Google Scholar 

  18. Zhang JH, Jin X, Li Y, Wang R, Guo W, Wang N, et al. Epoxide hydrolase Tyr113His polymorphism is not associated with susceptibility to esophageal squamous cell carcinoma in population of North China. World J Gastroenterol. 2003;9:2654–7.

    PubMed  CAS  Google Scholar 

  19. Casson AG, Zheng Z, Porter GA, Guernsey DL. Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma. Cancer Detect Prev. 2006;30:423–31.

    Article  PubMed  CAS  Google Scholar 

  20. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.

    Article  PubMed  Google Scholar 

  21. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.

    PubMed  CAS  Google Scholar 

  22. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.

    Article  PubMed  CAS  Google Scholar 

  23. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.

    Article  PubMed  CAS  Google Scholar 

  24. Wang LD, Zheng S, Liu B, Zhou JX, Li YJ, Li JX. CYP1A1, GSTs and mEH polymorphisms and susceptibility to esophageal carcinoma: study of population from a high-incidence area in North China. World J Gastroenterol. 2003;9:1394–7.

    PubMed  CAS  Google Scholar 

  25. Kuang G, Jin X, Li Y, Wang R, Guo W, Wang N, et al. Association of epoxide hydrolase Tyr113His polymorphism with susceptibility to esophageal squamous cell carcinoma in population of North China. Chinese Journal of Cancer Prevention and Treatment. 2004;11:685–8.

    CAS  Google Scholar 

  26. Arand M, Cronin A, Oesch F, Mowbray SL, Jones TA. The telltale structures of epoxide hydrolases. Drug Metab Rev. 2003;35:365–83.

    Article  PubMed  CAS  Google Scholar 

  27. Newman JW, Morisseau C, Hammock BD. Epoxide hydrolases: their roles and interactions with lipid metabolism. Prog Lipid Res. 2005;44:1–51.

    Article  PubMed  CAS  Google Scholar 

  28. Wang S, Zhu J, Zhang R, Gu Z. Association between microsomal epoxide hydrolase 1 T113C polymorphism and susceptibility to lung cancer. Tumour Biol. 2013;34:1045–52.

    Article  PubMed  CAS  Google Scholar 

  29. Zhao ZQ, Guan QK, Yang FY, Zhao P, Zhou B, Chen ZJ. System review and metaanalysis of the relationships between five metabolic gene polymorphisms and colorectal adenoma risk. Tumour Biol. 2012;33:523–35.

    Article  PubMed  CAS  Google Scholar 

Download references

Conflicts of interest

None

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, China

    Weixin Zhao & Xuwei Cai

  2. Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong An Road, Shanghai, 200032, China

    Weixin Zhao & Xuwei Cai

  3. Department of Health Statistics and Social Medicine, School of Public Health, Fudan University, Shanghai, 200032, China

    Jianfeng Luo

Authors
  1. Weixin Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jianfeng Luo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xuwei Cai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Weixin Zhao.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zhao, W., Luo, J. & Cai, X. Association between microsomal epoxide hydrolase 1 polymorphisms and susceptibility to esophageal cancer: a meta-analysis. Tumor Biol. 34, 2383–2388 (2013). https://doi.org/10.1007/s13277-013-0787-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13277-013-0787-y

Keywords

Search

Navigation