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The −590C/T polymorphism in the IL-4 gene and the risk of cancer: a meta-analysis

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Tumor Biology

Abstract

Interleukin-4 (IL-4) plays an important role in the pathogenesis of cancer. The −590C/T polymorphism in the IL-4 gene has been implicated in susceptibility to cancer, but the results have been inconclusive. The aim of this study was to analyze the association between this polymorphism with the risk of cancer by meta-analysis. PubMed, Embase, CNKI, and Wanfang databases were searched for all publications concerning the association between this polymorphism and cancer risk. Statistical analyses were analyzed by using RevMan 4.2 and STATA10.0 softwares. A total of 8,715 cases and 9,532 controls in 23 case–control studies were included. The results suggested that there was no significant association between IL-4 −590C/T polymorphism and cancer risks (TT + TC vs. CC: OR = 0.97, 95 % CI = 0.90–1.04, P = 0.36). In the subgroup analysis by ethnicity, no significant association was detected in Asians and Caucasians. In the subgroup analysis by cancer types, no significant association was found in gastric cancer and colorectal cancer. The current meta-analysis suggested that the −590C/T polymorphism in the IL-4 gene might not be associated with increased/decreased risk of cancer. The −590C/T polymorphism might be not a risk factor for cancers.

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Acknowledgments

We thank everyone who helped with this study. This study was supported by the Zhejiang Provincial Science and Technology Major Project (2009C13038), the National Natural Science Foundation of China (81071426, 30871362), the Natural Science Foundation of Zhejiang Province, China (D2080910, Y2081072), Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talents and Key Laboratory of Laboratory Medicine, Ministry of Education, Key Science and Technology Innovation Team of Zhejiang (2010R50048).

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Authors and Affiliations

  1. Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang, 325035, China

    Jie Zhang, Danli Xie, Huaibin Zhou, Runping Fan, Longyi Zhang, Cixiu Li, Sheng Jin, Qinghe Meng & Jianxin Lu

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  1. Jie Zhang
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Correspondence to Qinghe Meng or Jianxin Lu.

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Zhang, J., Xie, D., Zhou, H. et al. The −590C/T polymorphism in the IL-4 gene and the risk of cancer: a meta-analysis. Tumor Biol. 34, 2261–2268 (2013). https://doi.org/10.1007/s13277-013-0767-2

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  • DOI: https://doi.org/10.1007/s13277-013-0767-2

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