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Overexpression of keratin 17 is associated with poor prognosis in epithelial ovarian cancer

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Tumor Biology

Abstract

The aim of this study was to investigate the association between keratin 17 (K17) expression and the clinicopathological features of patients with epithelial ovarian cancer (EOC). K17 expression was detected by real-time quantitative RT-PCR in EOC and adjacent noncancerous tissues. In addition, K17 expression was analyzed by immunohistochemistry in 104 clinicopathologically characterized EOC cases. The expression levels of K17 mRNA and protein in EOC tissues were both significantly higher than those in noncancerous tissues. In addition, positive expression of K17 correlated with the clinical stage (p = 0.001). Furthermore, Kaplan–Meier survival analysis showed that a high expression level of K17 resulted in a significantly poor prognosis of EOC patients. Multivariate analysis revealed that EOC expression level was an independent prognostic parameter for the overall survival rate of EOC patients. Our data are the first to suggest that increased K17 expression in EOC is significantly associated with aggressive progression and poor prognosis. K17 may be an important molecular marker for predicting the carcinogenesis, progression, and prognosis of EOC.

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Acknowledgments

This work was supported by International Science and Technology Cooperation Program of China & Japan (no. 2010DFA31900), Major State Basic Research Development Program (2011CB503704), Program for Changjiang Scholars and Innovative Research Team in University, and National Natural Science Foundation of China (no. 60971055).

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Authors and Affiliations

  1. Department of Radiological Medicine and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, No. 17, Changle West Road, Xi’an, 710032, China

    Ya-Feng Wang, Hai-Yang Lang, Jie Zhang, Tao Zhao, Yu-Rong Li, Jun-Ye Liu, Li-Hua Zeng & Guo-Zhen Guo

  2. Department of Information Technology, The General Hospital of Jinan Military Command, No. 25, Shifan Road, Ji’nan, 250031, China

    Jing Yuan

  3. Department of Osteology, People’s Hospital of Langzhong City in Sichuan Province, No. 17 Zhangfei South Road, Langzhong, 637400, Sichuan Province, China

    Jun Wang

  4. Department of Health Statistics and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, No. 17, Changle West Road, Xi’an, 710032, China

    Rui Wang

  5. Department of Gynecologic Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450000, China

    Xin-Hui Zhang

Authors
  1. Ya-Feng Wang
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  2. Hai-Yang Lang
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  3. Jing Yuan
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  4. Jun Wang
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  5. Rui Wang
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  6. Xin-Hui Zhang
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  7. Jie Zhang
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  8. Tao Zhao
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  9. Yu-Rong Li
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  10. Jun-Ye Liu
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  11. Li-Hua Zeng
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  12. Guo-Zhen Guo
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Corresponding author

Correspondence to Li-Hua Zeng.

Additional information

Ya-Feng Wang, Hai-Yang Lang, and Jing Yuan contributed equally to this paper.

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Wang, YF., Lang, HY., Yuan, J. et al. Overexpression of keratin 17 is associated with poor prognosis in epithelial ovarian cancer. Tumor Biol. 34, 1685–1689 (2013). https://doi.org/10.1007/s13277-013-0703-5

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  • DOI: https://doi.org/10.1007/s13277-013-0703-5

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