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EGFR exon mutation distribution and outcome in non-small-cell lung cancer: a Portuguese retrospective study

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Tumor Biology

Abstract

Epidermal growth factor receptor (EGFR) mutations play a predictive role in advanced stages of non-small-cell lung cancer (NSCLC) patients. We conducted this study in order to assess EGFR status in a Portuguese population and its role in NSCLC patients' outcomes. Patients were submitted to EGFR assessment by high-resolution melting and/or direct sequencing. Kaplan–Meier curve was used to assess overall survival and progression-free survival (PFS). Two hundred forty eight out of 322 participants were assessed for EGFR status. Forty-two patients (16.9 %) presented EGFR-mutated status: one patient (2.4 %) presented exon 18; 21 patients (50 %), exon 19; one patient (2.4 %), exon 20; and 18 patients (45.2 %), exon 21 mutations, p < 0.001. PFS was not assessed (n.a.) for patient with exon 18 mutation, and for the other patients with mutations, it was 7 months (3.96–10.03) (exon 19), <1 month (exon 20), and 7 months (0–14.2) (exon 21) (p = 0.027). Overall survival (OS) was 11 months (exon 18), 11 months (1–18) (exon 19), 1 month (exon 20), and 7.5 months (2–70) (exon 21) (p = n.a). This study suggests that the EGFR mutation is herein observed in a higher proportion than expected for a Caucasian population, and OS is a little less than that published in the literature.

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Acknowledgments

The authors would like to acknowledge all colleagues from Portuguese Oncology Institute, Porto, Portugal, and from São João Hospital Center, University of Porto, Porto, Portugal for their help with patient treatment and data acquisition. Furthermore, we would like to acknowledge Catarina Cruz, PhD, Faculty of Medicine, University of Porto, for her critical comments and English review. This work was supported by the participant institutions' funding.

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Authors and Affiliations

  1. Department of Medical Oncology, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-079, Porto, Portugal

    Ramon Andrade de Mello, Dânia Sofia Marques, Júlio Oliveira, Ana Rodrigues, Marta Soares, Isabel Azevedo & António Araújo

  2. Department of Medicine, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319, Porto, Portugal

    Ramon Andrade de Mello, Venceslau Hespanhol & Henrique Queiroga

  3. Department of Pneumology, São João Hospital Center, Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319, Porto, Portugal

    Filipa Soares Pires, Venceslau Hespanhol & Henrique Queiroga

  4. Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-079, Porto, Portugal

    Ana Peixoto, Catarina Santos, Carla Pinto & Manuel R Teixeira

  5. Department of Pathology, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-079, Porto, Portugal

    Teresina Amaro

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  1. Ramon Andrade de Mello
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  2. Filipa Soares Pires
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  11. Venceslau Hespanhol
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Correspondence to Ramon Andrade de Mello.

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de Mello, R.A., Pires, F.S., Marques, D.S. et al. EGFR exon mutation distribution and outcome in non-small-cell lung cancer: a Portuguese retrospective study. Tumor Biol. 33, 2061–2068 (2012). https://doi.org/10.1007/s13277-012-0465-5

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  • DOI: https://doi.org/10.1007/s13277-012-0465-5

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