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Expression of the coxsackie and adenovirus receptor in human lung cancers

  • Research Article
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Tumor Biology

Abstract

The aim of this study is to elucidate the relation between expression of coxsackie and adenovirus receptor (CAR) and formation of lung cancer. We investigated the expression of CAR by immunohistochemistry, Western blot and real-time RT-PCR in 120 lung cancers. We found that CAR expression in tumor tissues was significantly higher than that in normal lung tissues. CAR expression had a correlation with the histological grade of lung squamous cell carcinoma; however, there was no relationship between the CAR expression and the other clinical pathological features. In vitro, silencing or overexpression of CAR could significantly inhibit or promote colony formation, cell adhesion, and invasion in A549 cells. Our findings demonstrated that CAR may play an essential role in the formation of lung cancer.

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Abbreviations

CAR:

the coxsackie and adenovirus receptor

SCC:

squamous cell carcinoma

AC:

adenocarcinoma

ANOVA:

a one-way analysis of variance

OD:

the average optical density

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Authors and Affiliations

  1. Department of Health and Environment, Institute of Health and Environmental Medicine, Key Laboratory of Risk Assessment and Control for Environment and Food Safety, No. 1, Dali Road, Tianjin, 300050, People’s Republic of China

    Zhaoli Chen, Jingran Sun, Min Jin, Zhiqiang Shen, Zhigang Qiu, Jingfeng Wang, Xinwei Wang & Jun-Wen Li

  2. Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, People’s Republic of China

    Qian Wang, Ankang Gu & Zhongli Zhan

Authors
  1. Zhaoli Chen
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  2. Qian Wang
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  3. Jingran Sun
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  4. Ankang Gu
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  5. Min Jin
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  6. Zhiqiang Shen
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  7. Zhigang Qiu
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  8. Jingfeng Wang
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  9. Xinwei Wang
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  10. Zhongli Zhan
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  11. Jun-Wen Li
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Corresponding authors

Correspondence to Zhongli Zhan or Jun-Wen Li.

Additional information

Authors Zhaoli Chen Qian Wang, and Jingran Sun contributed equally to this work.

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Chen, Z., Wang, Q., Sun, J. et al. Expression of the coxsackie and adenovirus receptor in human lung cancers. Tumor Biol. 34, 17–24 (2013). https://doi.org/10.1007/s13277-012-0342-2

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  • DOI: https://doi.org/10.1007/s13277-012-0342-2

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