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Prognostic analysis in node-negative gastric cancer patients in China

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Tumor Biology

Abstract

Gastric cancer patients with negative nodes were considered to have better outcomes, however, some of them still suffered from disease recurrences or distant metastases after radical resection. A total of 1,020 gastric carcinoma patients receiving treatment in our center between 2003 and 2008 were selected for the analysis. All patients received gastrectomy and D2 lymphadenectomy. Survival analysis was performed with Cox regression model. The final study includes 222 patients. The overall 5-year disease-specific survival rate was 73.0%. Factors bearing significant association with lower survival on univariate analysis included the age of 58 years old or more (P = 0.021), tumor size longer than 4 cm (P < 0.001), presence of angiolymphatic invasion (P = 0.006), proximal site (P = 0.030), serosal invasion (T3+T4, P = 0.003), and higher TNM stage (P < 0.001). Only three factors including serosal invasion, tumor size at least 4.0 cm, and presence of angiolymphatic invasion remained independent negative predictors of survival in multivariable analysis. These parameters can be employed to select node-negative gastric cancer patients for an adjuvant setting and close follow-up scheduling.

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Acknowledgments

This work was supported by National Natural Science Foundation of China grant 30672408, Guangzhou Bureau of Science and Technology grant 2006Z3-E0041 and Sun Yat-Sen University 985 Program Initiation Fund (China). We gratefully thank the staff members in the Department of Medical Oncology and Gastric and Pancreatic Surgery Oncology at Sun Yat-Sen University Cancer Center for their suggestion and assistance.

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Authors and Affiliations

  1. State Key Laboratory of Oncology in South China, Guangzhou, 510060, China

    Miao-zhen Qiu, Zhi-qiang Wang, Hui-yan Luo, Dong-sheng Zhang, Zhi-wei Zhou, Yu-hong Li, Wen-qi Jiang & Rui-hua Xu

  2. Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng Road East, Guangzhou, 510060, China

    Miao-zhen Qiu, Zhi-qiang Wang, Hui-yan Luo, Dong-sheng Zhang, Yu-hong Li, Wen-qi Jiang & Rui-hua Xu

  3. Department of Gastric and Pancreatic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China

    Zhi-wei Zhou

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  1. Miao-zhen Qiu
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  2. Zhi-qiang Wang
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  4. Dong-sheng Zhang
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Correspondence to Rui-hua Xu.

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Qiu, Mz., Wang, Zq., Luo, Hy. et al. Prognostic analysis in node-negative gastric cancer patients in China. Tumor Biol. 32, 489–492 (2011). https://doi.org/10.1007/s13277-010-0142-5

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  • DOI: https://doi.org/10.1007/s13277-010-0142-5

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