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Tumor markers AFP, CA 125, and CA 19-9 in the long-term follow-up of sacrococcygeal teratomas in infancy and childhood

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Tumor Biology

Abstract

Given the tendency of a proportion of sacrococcygeal teratomas (SCT) to recur, we evaluated whether serial tumor marker measurements are helpful in the management of these children. Between 1985 and 2006, 32 children with SCT were followed up for 1–15 years, and a total of 344, 197, and 193 serial samples for serum alpha-fetoprotein (AFP), CA 125, and CA 19-9 were analyzed, respectively. Six children with neonatal SCT developed eight recurrences. Serum AFP was elevated in two of two children prior to diagnosis of malignant recurrences (yolk sac tumor and adenocarcinoma), and CA 125 was elevated in one third of mature and one third of immature recurrences. CA 19-9 remained within reference values in relation to recurrences of neonatal SCT. Taken together, serum CA 125 measurements may complement the use of serum AFP in the follow-up of SCT.

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Authors and Affiliations

  1. Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland

    Satu-Liisa Pauniaho

  2. Departments of Pathology and Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Olga Tatti

  3. Children’s Hospital, University of Helsinki, Helsinki, Finland

    Pekka Lahdenne, Harry Lindahl, Mikko Pakarinen & Risto Rintala

  4. Children’s Hospital and Pediatric Research Center, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland

    Markku Heikinheimo

Authors
  1. Satu-Liisa Pauniaho
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  2. Olga Tatti
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  3. Pekka Lahdenne
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  4. Harry Lindahl
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  5. Mikko Pakarinen
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  6. Risto Rintala
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  7. Markku Heikinheimo
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Correspondence to Markku Heikinheimo.

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Pauniaho, SL., Tatti, O., Lahdenne, P. et al. Tumor markers AFP, CA 125, and CA 19-9 in the long-term follow-up of sacrococcygeal teratomas in infancy and childhood. Tumor Biol. 31, 261–265 (2010). https://doi.org/10.1007/s13277-010-0026-8

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  • DOI: https://doi.org/10.1007/s13277-010-0026-8

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