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Correlation of constitutive photomorphogenic 1 (COP1) and p27 tumor suppressor protein expression in ovarian cancer

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Abstract

Background

Constitutive photomorphogenic 1 (COP1) is an E3 ubiquitin ligase that regulates important target proteins for cell growth including p27. The tumor suppressor p27 negatively regulates the cell cycle by inhibiting cyclin-dependent kinase. COP1 negatively regulates p27 stability by mediating its nuclear export and degradation.

Objective

Even if COP1 and p27 are tightly related and have significant roles in tumor progression, the expression patterns and relationship of both proteins in cancer have not yet been studied.

Method

We analyzed the expression patterns and relationship between COP1 and p27 using an ovarian cancer tissue microarray by dual immunofluorescence analysis.

Results

The expression levels of COP1 and p27 proteins were not significantly different between ovarian cancer tissue and normal control tissue. Other clinical data including age, tumor type, tumor grade, and stage were not significantly related to expression of the two proteins. The co-relationship between COP1 and p27 proteins was significantly high (Pearson correlation coefficient 0.79, p = 8.65 × 10−22).

Conclusions

Our results demonstrate that while the expression levels of COP1 and p27 are highly correlated, they are not significantly related to cancer progression in ovarian cancer.

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Author notes

  1. Eun-Ji Ko and Young Lim Oh contributed equally to this work as first author.

Authors and Affiliations

  1. Department of Parasitology and Genetics, Kosin University College of Medicine, Busan, Republic of Korea

    Eun-Ji Ko, Mee Sun Ock & Hee-Jae Cha

  2. Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan, Republic of Korea

    Eun-Ji Ko

  3. Department of Obstetrics and Gynecology, Kosin University College of Medicine, Busan, Republic of Korea

    Young Lim Oh & Heung Yeol Kim

  4. Department of Internal Medicine, Kyung Hee University, Seoul, Republic of Korea

    Wan Kyu Eo

  5. Department of Obstetrics and Gynecology, Hallym University College of Medicine, Chuncheon, Republic of Korea

    Hongbae Kim

  6. Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea

    Ki Hyung Kim

  7. Biomedical Research Institute and Pusan Cancer Center, Pusan National University Hospital, Busan, Republic of Korea

    Ki Hyung Kim

  8. Department of Obstetrics and Gynecology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea

    Suk Bong Koh

  9. Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan, Republic of Korea

    Yung Hyun Choi

  10. Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA

    Ari Kim

  11. Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Hyun Ho Choi

  12. Research Institute of Gastroenterology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Hyun Ho Choi

  13. Department of Obstetrics and Gynecology, Eulji Medical Center, Eulji University, Seoul, Republic of Korea

    Eun Joo Park

Authors
  1. Eun-Ji Ko
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  2. Young Lim Oh
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  3. Heung Yeol Kim
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  4. Wan Kyu Eo
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  6. Ki Hyung Kim
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  7. Suk Bong Koh
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  8. Mee Sun Ock
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  9. Yung Hyun Choi
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  10. Ari Kim
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  13. Hee-Jae Cha
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Corresponding authors

Correspondence to Eun Joo Park or Hee-Jae Cha.

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Conflict of interest

Author Eun-Ji Ko, author Young Lim Oh, author Heung Yeol Kim, author Wan Kyu Eo, author Hongbae Kim, author Ki Hyung Kim, author Suk Bong Koh, author Mee Sun Ock, author Yung Hyun Choi, author Ari Kim, author Hyun Ho Choi, author Eun Joo Park, and author Hee-Jae Cha declare that they have no conflict of interest.

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Ko, EJ., Oh, Y.L., Kim, H.Y. et al. Correlation of constitutive photomorphogenic 1 (COP1) and p27 tumor suppressor protein expression in ovarian cancer. Genes Genom 41, 879–884 (2019). https://doi.org/10.1007/s13258-019-00818-6

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  • DOI: https://doi.org/10.1007/s13258-019-00818-6

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