Abstract
Prostate cancer (PCa) is the most commonly diagnosed cancer in the developed world, and the incidence of this cancer is rising rapidly in many countries. Several polymorphic genes encoding enzymes involved carcinogenesis have been studied as potential risk factor of prostate cancer. Genetic polymorphisms in glutathione S-transferases M1 (GSTM1), T1 (GSTT1) and P1 (GSTP1) genes have been constantly reported to have a meaningful effect on prostate cancer risk. But other surveys of this relationship have yielded inconsistent results. To assess the possible contribution of the GSTM1, GSTT1, and GSTP1 gene polymorphisms in prostate cancer, we performed a population-based study of 139 prostate cancer patients and 115 healthy controls based on their genotype distributions of the genes. There were no differences in distributions of genotype frequencies of GSTM1 and GSTP1 polymorphisms between prostate cancer patients and controls (OR 1.60, 95 % CI 0.886–2.860 for GSTM1 and OR 1.38, 95 % CI 0.739–2.577 for GSTP1). In contrast, the distribution of GSTT1-null genotype is significantly different between the prostate cancer case and controls (OR 0.26, 95 % CI 0.128–0.518, p < 0.001). Meanwhile, GSTP1 I/V and V/V genotypes were significantly associated with prostate cancer where the PSA level was more than 10.0 (OR 2.73, 95 % CI 1.319–5.639, p = 0.006). Thus, our data imply that the GSTT1-null genotype may not be a risk factor but a protective factor of prostate cancer and GSTP1 Val allele is a risk factor for the prostate cancer where the PSA level was high, although functional studies with larger sample size are necessary to elucidate these findings.
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Ashtiani ZO, Hasheminasab SM, Ayati M, Goulian BS, Modarressi MH (2010) Are GSTM1, GSTT1 and CAG repeat length of androgen receptor gene polymorphisms associated with risk of prostate cancer in Iranian patients? Pathol Oncol Res 17:269–275
Attard G, Parker C, Eeles RA, Schröder F, Tomlins SA, Tannock I, Drake CG, de Bono JS (2015) Prostate cancer. Lancet. doi:10.1016/S0140-6736(14)61947-4 (in press)
Bansal VK, Rajan K, Sharma A, Paliwal P, Chaubal G, Jindal V, Misra M.C, Kucheria K (2014) Prospective case–control study to evaluate the role of glutathione s transferases (GSTT1 and GSTM1) gene deletion in breast carcinoma and its prognostic significance. Indian J Surg 1–6
Cai Q, Wang Z, Zhang W, Guo X, Shang Z, Jiang N, Tian J, Niu Y (2013) Association between glutathione S-transferases M1 and T1 gene polymorphisms and prostate cancer risk: a systematic review and meta-analysis. Tumour Biol 35:247–256
Chen R, Ren S, Chinese Prostate Cancer Consortium, Yiu MK, Fai NC, Cheng WS, LH Ian, Naito S, Matsuda T, Kehinde E et al (2014) Prostate cancer in Asia: a collaborative report. Asian J Urol 1:15–29
Cho IC, Kim JE, Kim SH, Joung JY, Seo HK, Chung JS, Park WS, Lee KH (2015) Oncologic aspects of long-term followed incidental prostate cancer detected by cystoprostatectomy in Korean patients. Prostate Int 3:56–61
Haholu A, Berber U, KaragözB Tuncel T, Bilgi O, Demirel D (2013) Is there any association of glutathione S-transferase T1 (GSTT1) and glutathione S-transferase M1 (GSTM1) gene polymorphism with gastric cancers? Pol J Pathol 64:247–252
Jung KW, Won YJ, Kong HJ, Oh CM, Seo HG, Lee JS (2013) Cancer statistics in Korea: incidence, mortality, survival and prevalence in 2010. Cancer Res Treat 45:1–14
Karagas MR, Park S, Warren A, Hamilton J, Nelson HH, Mott LA, Kelsey KT (2005) Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Lett 219:63–69
Kesarwani P, Singh R, Mittal RD (2009) Association of GSTM3 intron 6 variant with cigarette smoking, tobacco chewing and alcohol as modifier factors for prostate cancer risk. Arch Toxicol 83:351–356
Kim HJ, Liu X, Wang H, Kohyama T, Kobayashi T, Wen FQ, Romberger DJ, Abe S, MacNee W, Rahman I et al (2002) Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke. Am J Physiol Lung Cell Mol Physiol 283:L409–L417
Kim EJ, Jeong P, Quan C, Kim J, Bae SC, Yoon SJ, Kang JW, Lee SC, Jun Wee J, Kim WJ (2005) Genotypes of TNF-alpha, VEGF, hOGG1, GSTM1, and GSTT1: useful determinants for clinical outcome of bladder cancer. Urology 65:70–75
Kim W, Yoo TK, Kim SJ, Shin DJ, Tyler-Smith C, Jin HJ, Kwak KD, Kim ET, Bae YS (2007) Lack of association between Y-chromosomal haplogroups and prostate cancer in the Korean population. PLoS ONE 2:e172
Kim W, Yoo TK, Shin DJ, Rho HW, Jin HJ, Kim ET, Bae YS (2008) Mitochondrial DNA haplogroup analysis reveals no association between the common genetic lineages and prostate cancer in the Korean population. PLoS ONE 3:e2211
Konwar R, Manchanda PK, Chaudhary P, Nayak VL, Singh V, Bid HK (2010a) Glutathione S-transferase gene variants and risk of benign prostate hyperplasia in a North Indian population. Asian Pac J Cancer Prev 11:365–370
Konwar R, Manchanda PK, Chaudhary P, Nayak VL, Singh V, Bid HK (2010b) Glutathione S-transferase (GST) gene variants and risk of benign prostatic hyperplasia: a report in a North Indian population. Asian Pac J Cancer Prev 11:1067–1072
Lavender NA, Benford ML, VanCleave TT, Brock GN, Kittles RA, Moore JH, Hein DW, Kidd LC (2009) Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study. BMC Cancer 16:397
Lee WH, Morton RA, Epstein JI, Brooks JD, Campbell PA, Bova GS, Hsieh WS, Isaacs WB, Nelson WG (1994) Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis. Proc Natl Acad Sci USA 91:11733–11737
Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K (2000) Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 343:78–85
Mao GE, Morris G, Lu QY, Cao W, Reuter VE, Cordon-Cardo C, Dalbagni G, Scher HI, deKernion JB, Zhang ZF (2004) Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer. Cancer Detect Prev 28:368–374
McIlwain CC, Townsend DM, Tew KD (2006) Glutathione S-transferase polymorphisms: cancer incidence and therapy. Oncogene 25:1639–1648
Minelli C, Wei I, Sagoo G, Jarvis D, Shaheen S, Burney P (2011) Interactive effects of antioxidant genes and air pollution on respiratory function and airway disease: a HuGE review. Am J Epidemiol 173:603–620
Mitchell T, Neal DE (2015) The genomic evolution of human prostate cancer. Br J Cancer 113:193–198
Mittal RD, Kesarwani P, Singh R, Ahirwar D, Mandhani A (2009) GSTM1, GSTM3 and GSTT1 gene variants and risk of benign prostate hyperplasia in North India. Dis Mark 26:85–91
Mo Z, Gao Y, Cao Y, Gao F, Jian L (2009) An updating meta-analysis of the GSTM1, GSTT1, and GSTP1 polymorphisms and prostate cancer: a HuGE review. Prostate 69:662–688
Ntais C, Polycarpou A, Ioannidis JP (2005) Association of GSTM1, GSTT1, and GSTP1 gene polymorphisms with the risk of prostate cancer: a meta-analysis. Cancer Epidemiol Biomark Prev 14:176–181
Pan C, Zhu G, Yan Z, Zhou Y, Liu Z (2014) Glutathione S-transferase T1 and M1 polymorphisms are associated with lung cancer risk in a gender-specific manner. Oncol Res Treat 37:164–169
Qadri Q, Sameer AS, Shah ZA, Hamid A, Alam S, Manzoor S, Siddiqi MA (2011) Genetic polymorphism of the glutathione-S-transferase P1 gene (GSTP1) and susceptibility to prostate cancer in the Kashmiri population. Genet Mol Res 10:3038–3045
Så RA, Moreira Ados S, Cabello PH, Ornellas AA, Costa EB, Matos Cda S, Alves G, Hatagima A (2014) Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population. Int Braz J Urol 40:463–473
Safarinejad MR, Shafiei N, Safarinejad SH (2011) Glutathione S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and prostate cancer: a case-control study in Tehran. Iran. Prostate Cancer Prostatic Dis 14:105–113
Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual, 2nd edn. Cold Spring Harbor Laboratory Press, New York
Sissung TM, Price DK, Del Re M, Ley AM, Giovannetti E, Figg WD, Danesi R (2014) Genetic variation: effect on prostate cancer. Biochim Biophys Acta 1846:446–456
Srivastava DS, Mandhani A, Mittal B, Mittal RD (2005) Genetic polymorphism of glutathione S-transferase genes (GSTM1, GSTT1 and GSTP1) and susceptibility to prostate cancer in Northern India. BJU Int 95:170–173
Townsend D, Tew K (2003) Cancer drugs, genetic variation and the glutathione-S-transferase gene family. Am J Pharmacogn 3:157–172
Vickers AJ, Sjoberg DD, Ankerst DP, Tangen CM, Goodman PJ, Thompson IM Jr (2013) The prostate cancer prevention trial risk calculator and the relationship between prostate-specific antigen and biopsy outcome. Cancer 119:3007–3011
Wei B, Xu Z, Zhou Y, Ruan J, Cheng H, Xi B, Zhu M, Jin K, Zhou D, Hu Q et al (2012) Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies. PLoS ONE 7:e46982
Zhao Y, Wang B, Hu K, Wang J, Lu SU, Zhang Y, Lu W, Zhao E, Yuan L (2015) Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: a meta-analysis of 26 case-control studies. Oncol Lett 9:1947–1953
Zhou TB, Drummen GP, Jiang ZP, Qin YH (2014) GSTT1 polymorphism and the risk of developing prostate cancer. Am J Epidemiol 180:1–10
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The present research was conducted by the research fund of Dankook University in 2013.
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This study was approved by the Ethics Committee and institutional review boards of Eulji Medical Center of the Eulji University School of Medicine in Seoul, Korea.
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Shin, YE., Hwang, IW. & Jin, HJ. Association between glutathione S-transferases M1, T1 and P1 gene polymorphisms and prostate cancer in Koreans. Genes Genom 38, 235–241 (2016). https://doi.org/10.1007/s13258-015-0382-2
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DOI: https://doi.org/10.1007/s13258-015-0382-2