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Fabrication and Characterization of Electrospun Bi-Hybrid PU/PET Scaffolds for Small-Diameter Vascular Grafts Applications

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Abstract

In spite of advances have been made during the past decades, the problems associated with small-diameter vascular grafts, including low patency and compliance mismatch and in consequence of that thrombosis, aneurysm and intimal hyperplasia are still challenges. To address these problems, net polyurethane (PU) and poly (ethylene terephthalate) (PET) polymers and hybrid PU/PET were electrospun to create three different types of small-diameter vascular scaffolds due to their unique physicochemical characteristics: PU, PET, and novel hybrid PU/PET scaffolds. The results show that the PU and PET composite can improve the mechanical properties of the tissue-engineered vascular scaffolds in the range of the native vessels where the non-cytotoxicity characteristic of these well-known polymers is still immutable. The compliance and stiffness factor of the fabricated hybrid scaffolds were 4.468 ± 0.177 and 22.718 ± 0.896%/0.01 mmHg, respectively, which were significantly different with that of the net PU and PET electrospun scaffolds. Other properties such as ultimate tensile stress (UTS) (3.56 ± 1.21 MPa) were also in good accordance with the native vessels. Furthermore, FT-IR analysis testified the presence of both PU and PET in the hybrid scaffolds. Overall, we were able to fabricate a hybrid scaffold as a small-diameter vascular graft that mechanically matched the gold standard of blood vessel substitution.

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Acknowledgments

The Authors gratefully acknowledge the University of Sistan and Baluchestan for supporting this research (Grant No. G932/2/1006).

Conflict of interest

The Second author has received research grants from the University of Sistan and Baluchestan (Grant No. G932/2/1006). The first author declares that she has no conflict of interest. The second author declares that he has no conflict of interest. The third author declares that she has no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Authors and Affiliations

  1. Chemical Engineering Department, University of Sistan and Baluchestan, Zahedan, Iran

    Marziyeh Khodadoust, Davod Mohebbi-Kalhori & Nafiseh Jirofti

  2. Institute of Nanotechnology, University of Sistan and Baluchestan, Zahedan, Iran

    Davod Mohebbi-Kalhori

  3. University of Sistan and Baluchestan Central Laboratory, Zahedan, Iran

    Davod Mohebbi-Kalhori

Authors
  1. Marziyeh Khodadoust
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  2. Davod Mohebbi-Kalhori
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  3. Nafiseh Jirofti
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Correspondence to Davod Mohebbi-Kalhori.

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Associate Editor John M. Tarbell oversaw the review of this article.

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Khodadoust, M., Mohebbi-Kalhori, D. & Jirofti, N. Fabrication and Characterization of Electrospun Bi-Hybrid PU/PET Scaffolds for Small-Diameter Vascular Grafts Applications. Cardiovasc Eng Tech 9, 73–83 (2018). https://doi.org/10.1007/s13239-017-0338-6

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  • DOI: https://doi.org/10.1007/s13239-017-0338-6

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