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Imaging Biomarkers for Intra-arterial Stroke Therapy

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Abstract

Despite high rates of early revascularization with intra-arterial stroke therapy, the clinical efficacy of this approach has not been clearly demonstrated. Neuroimaging biomarkers will be useful in future trials for patient selection and for outcomes evaluation. To identify patients who are likely to benefit from intra-arterial therapy, the combination of vessel imaging, infarct size quantification and degree of neurologic deficit appears critical. Perfusion imaging may be useful in specific circumstances, but requires further validation. For measuring treatment outcomes, surrogate biomarkers that appear suitable are angiographic reperfusion as measured by the modified Thrombolysis in Cerebral Infarction scale and final infarct volume.

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Authors and Affiliations

  1. Division of Diagnostic and Interventional Neuroradiology, Department of Imaging, Massachusetts General Hospital, 55 Fruit Street GRB 241, Boston, MA, 02114, USA

    Olvert A. Berkhemer, Shervin Kamalian, R. Gilberto González & Albert J. Yoo

  2. Harvard Medical School, Boston, MA, USA

    Olvert A. Berkhemer, Shervin Kamalian, R. Gilberto González & Albert J. Yoo

  3. Department of Radiology, Academic Medical Center Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

    Olvert A. Berkhemer & Charles B. L. M. Majoie

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  1. Olvert A. Berkhemer
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  2. Shervin Kamalian
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Associate Editor Ajit P. Yoganathan oversaw the review of this article.

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Berkhemer, O.A., Kamalian, S., González, R.G. et al. Imaging Biomarkers for Intra-arterial Stroke Therapy. Cardiovasc Eng Tech 4, 339–351 (2013). https://doi.org/10.1007/s13239-013-0148-4

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  • DOI: https://doi.org/10.1007/s13239-013-0148-4

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