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Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery

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Abstract

This manuscript reports on the synthesis of biodegradable polyurethanes (PU) using poly(ε-caprolactone) diol and fabrication of microspheres containing dexamethasone (DEX). Biodegradable PUs with different isocyanate ratios were successfully synthesized using PCL diol as a polyol. The PU with a high isocyanate ratio exhibited a low average molecular weight, high melting point, high Young’s modulus, low tensile strength, low elongation to break, low hydrolytic degradation rate, and fast release profile of DEX. These results can be used to optimize properties so as to be suitable for specific applications. Our next goal is to evaluate the performance of PU microspheres as an injectable cartilage filler through in vitro and in vivo studies. In addition, the biodegradable PUs can be used for tissue-engineered scaffolds using three-dimensional printing.

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References

  1. J. P. Santerre, K. Woodhouse, G. Laroche, and R. S. Labow, Biomaterials, 26, 7457 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. D. S. Huh and S. L. Cooper, Polym. Eng. Sci., 11, 369 (1971).

    Article  CAS  Google Scholar 

  3. T. G. Grasel, D. C. Lee, A. Z. Okkema, T. J. Slowinski, and S. L. Cooper, Biomaterials, 9, 383 (1988).

    Article  CAS  PubMed  Google Scholar 

  4. L. Tatai, T. G. Moore, R. Adhikari, F. Malherbe, R. Jayasekara, I. Griffiths, and P. A. Gunatillake, Biomaterials, 28, 5407 (2007).

    Article  CAS  PubMed  Google Scholar 

  5. G. R. da Silva, A. da Silva-Cunha, F. Behar-Cohen, E. Ayres, and R. L. Oréfice, Polym. Degrad. Stab., 95, 491 (2010).

    Article  Google Scholar 

  6. A. Patel and K. Mequanint, Macromol. Biosci., 7, 727 (2007).

    Article  CAS  PubMed  Google Scholar 

  7. I. Engelberg and J. Kohn, Biomaterials, 12, 292 (1991).

    Article  CAS  PubMed  Google Scholar 

  8. K. Gisselfalt, B. Edberg, and P. Flodin, Biomacromolecules, 3, 951 (2002).

    Article  CAS  PubMed  Google Scholar 

  9. T. F. Yang, W. K. Chin, J. Y. Cherng, and M. D. Shau, Biomacromolecules, 5, 1926 (2004).

    Article  CAS  PubMed  Google Scholar 

  10. J. Zhang, B. A. Doll, E. J. Beckman, and J. O. Hollinger, J. Biomed. Mater. Res. A, 67, 389 (2003).

    Article  PubMed  Google Scholar 

  11. M. Shoaiba, A. Bahadura, A. Saeeda, M. S. Rahmanb, and M. M. Naseera, React. Funct. Polym., 127, 153 (2018).

    Article  Google Scholar 

  12. S. Subramani, Y.-J. Park, Y.-S. Lee, and J.-H. Kim, Prog. Org. Coat., 48, 71 (2003).

    Article  CAS  Google Scholar 

  13. S.-H. Hsu, C.-W. Chen, K.-C. Hung, Y.-C. Tsai, and S. Li, Polymers, 8, 252 (2016).

    Article  PubMed Central  Google Scholar 

  14. J. J. Bunim, R. L. Black, L. Lutwak, R. E. Peterson, and G. D. Whedon, Arthritis. Rheumatol., 1, 313 (1958).

    Article  CAS  Google Scholar 

  15. L. Bian, A. M. Stoker, K. M. Marberry, G. A. Ateshian, J. L. Cook, and C. T. Hung, Am. J. Sport. Med., 38, 1 (2010).

    Article  Google Scholar 

  16. F. L. Devedec, H. Boucher, D. Dubins, and C. Allen, Mol. Pharmaceut., 15, 1565 (2018).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Biotechnology, The Catholic University of Korea, Bucheon, Gyeonggi, 14662, Korea

    Juri Park, Min Jeong Lee, Guk Young Ahn, Tae Hoon Yun, Inseong Choi, Eun Seong Lee & Sung-Wook Choi

  2. Basic Research & Innovation Division, Amorepacific R&D Center, Yongin, Gyeonggi, 17074, Korea

    Hyunsuk Lee

Authors
  1. Juri Park
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  2. Min Jeong Lee
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  3. Guk Young Ahn
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  4. Tae Hoon Yun
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  5. Inseong Choi
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  6. Eun Seong Lee
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  7. Hyunsuk Lee
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  8. Sung-Wook Choi
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Correspondence to Sung-Wook Choi.

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Acknowledgments: This study was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2015R1A4A1042350 and NRF-2017R1A2B4008093) and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry Health & Welfare, Republic of Korea (HI17C0886), and the Research Fund, 2018 of The Catholic University of Korea.

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Park, J., Lee, M.J., Ahn, G.Y. et al. Synthesis and Characterizations of Biodegradable Polyurethane Microspheres with Dexamethasone for Drug Delivery. Macromol. Res. 27, 839–842 (2019). https://doi.org/10.1007/s13233-019-7171-8

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  • DOI: https://doi.org/10.1007/s13233-019-7171-8

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