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pH-Sensitive Polypeptide Conjugated with Carborane Clusters and Cyanine for NIR Bioimaging and Multi-Therapies

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Abstract

A novel pH-sensitive carborane and cyanine dye conjugated polypeptide and its micelles has been designed and synthesized for potential near infrared fluorescence imaging-guided boron neutron capture therapy (BNCT). The amphiphilic polymer we synthesized with tertiary amine as functional group could self-assemble to micelle nanoparticles at neutral pH, and responsive to acidic solution for the disassembly of the micelles for drug release. The tertiary amine sensitive induced process was observed via dynamic light scattering (DLS) and transmission electron microscopy (TEM). The efficiency of cell killing ability is studied by MTT assays and fluorescence microscope measurement, indicating a new intelligent system for potential NIR imaging-guided therapy.

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Author notes

  1. These authors equally contributed to this work.

Authors and Affiliations

  1. CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at the Microscale, and Department of Chemical Physics, iChEM, University of Science and Technology of China, Jinzai Road 96#, Hefei, 230026, Anhui, P. R. China

    Zheng Ruan, Pan Yuan, Titao Jing & Lifeng Yan

  2. Institute of System and Engineering, Chinese Academy of Engineering Physics, Mianyang, P. R. China

    Tao Xing

Authors
  1. Zheng Ruan
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  2. Pan Yuan
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  3. Titao Jing
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  4. Tao Xing
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  5. Lifeng Yan
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Corresponding authors

Correspondence to Zheng Ruan, Tao Xing or Lifeng Yan.

Additional information

Acknowledgment: This work is supported by the National Natural Science Foundation of China (No. 51373162, 21404095, and 51673180).

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Ruan, Z., Yuan, P., Jing, T. et al. pH-Sensitive Polypeptide Conjugated with Carborane Clusters and Cyanine for NIR Bioimaging and Multi-Therapies. Macromol. Res. 26, 270–277 (2018). https://doi.org/10.1007/s13233-018-6034-z

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  • DOI: https://doi.org/10.1007/s13233-018-6034-z

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