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Pattern-coated titanium bone fixation plate for dual delivery of vancomycin and alendronate

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Abstract

Metallic bone-fixation devices have been widely used in the treatment of fractured bones. However, there are still some unmet clinical needs associated with post-surgical infection and hampered bone repair. Therefore, to both prevent infection and enhance bone formation, we propose a titanium (Ti)-based bone plate for dual delivery of an antibiotic, vancomycin (VAN), and a bone-forming drug, alendronate (AL). In this work, we prepared the coating with a blend of a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), and a drug, VAN or AL. Instead of coating the whole surface, we patterned the coatings each in the shape of a dot, on a flat surface of the Ti bone plate currently in clinical use (BP0001-PT, U&I, Korea). This way, we could prevent detachment of the polymeric coating from the metallic plate surface while being immersed in an aqueous medium for 23 days. Both VAN and AL were released in a sustained manner for more than 28 days, maintaining their own activity without being influenced by their co-existence in the medium. Thus, the coated plate showed an antibacterial activity against Staphylococcus aureus, while also promoting osteoblast proliferation and alkaline phosphate activity in MG-63 cells. Therefore, we conclude that a Ti-based bone plate coated with patterned dots, each for delivery of VAN or AL, can be a promising strategy to allow for both antibacterial and bone-forming activities.

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, Seoul, 03080, Korea

    Chun Gwon Park, Seung Ho Lee & Young Bin Choy

  2. Interdisciplinary Program for Bioengineering, College of Engineering, Seoul National University, Seoul, 08826, Korea

    Min Park & Young Bin Choy

  3. Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, 03080, Korea

    Byung Hwi Kim & Young Bin Choy

  4. School of Mechanical Engineering, College of Engineering, Chung-Ang University, Seoul, 06974, Korea

    Joong Yull Park & Ho Hyun Park

  5. Program in Nano science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Korea

    Kangwon Lee

  6. Advanced Institute of Convergence Technology, Gyeonggi, 16229, Korea

    Kangwon Lee

  7. Center for Biomaterials, Korea Institute of Science & Technology, Seoul, 02792, Korea

    Hyun-Kwang Seok

Authors
  1. Chun Gwon Park
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  2. Min Park
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  3. Byung Hwi Kim
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  4. Seung Ho Lee
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  9. Young Bin Choy
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Corresponding author

Correspondence to Young Bin Choy.

Additional information

Acknowledgments: This work was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (HI14C2194) and a grant of the Collaborative Research Program of SNU Boramae Medical Center and Basic Medical Science from Seoul National University College of Medicine (800-20170004).

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Park, C.G., Park, M., Kim, B.H. et al. Pattern-coated titanium bone fixation plate for dual delivery of vancomycin and alendronate. Macromol. Res. 25, 756–762 (2017). https://doi.org/10.1007/s13233-017-5073-1

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  • DOI: https://doi.org/10.1007/s13233-017-5073-1

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