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Photocurable O-carboxymethyl chitosan derivatives for biomedical applications: Synthesis, in vitro biocompatibility, and their wound healing effects

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An Erratum to this article was published on 01 November 2012

Abstract

In this work, photocurable water-soluble chitosan derivatives were prepared for biomedical applications by modifying water-soluble O-carboxymethyl chitosan (O-CMC) derivatives with furfuryl glycidyl ether (O-CMC/FGE). Successful derivatization of chitosan to the final product (O-CMC/FGE) was verified by UV and 1H NMR spectral analysis. The degree of photo-crosslinking was measured by a flow distance experiment after exposure to visible light for a certain period of time. The degree of crosslinking increased linearly in proportion to exposure time. The in vitro cell viability test revealed a lack of cytotoxicity of O-CMC/FGE against mouse 3T3 fibroblasts. However, poor cell attachment was observed for the cells seeded onto the photocured O-CMC/FGE; this is likely due to the anionic nature of this material. O-CMC/FGE displayed wound healing effects in an in vivo animal experiment using a burn wound model. Due to its good biocompatibility, wound healing effect, and mild cross-linking condition, together with an inhibitory effect on cell attachment, O-CMC/FGE would be a promising candidate as an anti-adhesion material for biomedical applications.

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Authors and Affiliations

  1. Department of Biotechnology and Bio-Environmental Technology (BET) Research Institute, Chung-Ang University, Gyeonggi, 456-756, Korea

    Ha-Na Na, Shin-Hye Park, Kwang-Il Kim & Tae-Il Son

  2. Department of Pathology, College of Medicine, Chung-Ang University, Seoul, 156-756, Korea

    Mi Kyung Kim

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  1. Ha-Na Na
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  2. Shin-Hye Park
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  3. Kwang-Il Kim
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  4. Mi Kyung Kim
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  5. Tae-Il Son
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Correspondence to Tae-Il Son.

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Na, HN., Park, SH., Kim, KI. et al. Photocurable O-carboxymethyl chitosan derivatives for biomedical applications: Synthesis, in vitro biocompatibility, and their wound healing effects. Macromol. Res. 20, 1144–1149 (2012). https://doi.org/10.1007/s13233-012-0167-2

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  • DOI: https://doi.org/10.1007/s13233-012-0167-2

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