Skip to main content
SpringerLink
Log in

Nitrogen grafting onto polycarprolactone by a simple surface modification with atmospheric pressure glow discharge (Ar-APGD) and promoted neonatal human fibroblast growth

  • Articles
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

Plasma surface modifications of polymer scaffolds using biomolecules such as oxygen, nitrogen, and other active grafting molecules have been studied to enhance biological responses such as cell attachment, spreading, and proliferation. According to the reports, nitrogen grafting requires corrosive or mixture gas environment, or post treatment. This study aimed to evaluate a simple atmospheric pressure plasma surface modification in order to graft nitrogen derivatives and to promote biological responses. In this study, a polycarprolactone (PCL) film was modified within 10 min by argon atmospheric pressure discharge (Ar-APGD). Excited argon atoms, nitrogen atoms, oxygen atoms, and hydroxyl functional groups were observed from the optical emission spectra of the discharge. Decreased carbonyl functional groups and ether functional groups were observed; notably, immobilized nitrogen was observed on the PCL surface after the Ar-APGD treatment. Promoted neonatal Human Dermal Fibroblast (nHDF) growth patterns were observed on the Ar-APGD-treated surface.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. M. A. Woodruff and D. W. Hutmacher, Prog. Polym. Sci., 35, 1217 (2010).

    Article  CAS  Google Scholar 

  2. A. Gloria, R. D. Santis, and L. Ambrosio, J. Appl. Biomater. Biomech., 8, 57 (2010).

    CAS  Google Scholar 

  3. Y. Dong, S. Liao, M. Ngiam, C. K. Chan, and S. Ramakrishna, Tissue Eng. Part B: Rev., 15, 333 (2009).

    Article  CAS  Google Scholar 

  4. J. S. Park, J. M. Kim, S. J. Lee, S. G. Lee, Y. K. Jeong, S. E. Kim, and S. C. Lee, Macromol. Res., 15, 424 (2007).

    Article  CAS  Google Scholar 

  5. K. Park, H. J. Jung, J. J. Kim, K. D. Ahn, D. K. Han, and Y. M. Ju, Macromol. Res., 14, 552 (2006).

    Article  CAS  Google Scholar 

  6. H. Park, K. Y. Lee, S. J. Lee, K. E. Park, and W. H. Park, Macromol. Res., 15, 238 (2007).

    Article  CAS  Google Scholar 

  7. S. C. Jin, H. S. Baek, Y. I. Woo, M. H. Lee, J. S. Kim, J. C. Park, Y. H. Park, D. K. Rah, K. H. Chung, S. J. Lee, and I. H. Han, Macromol. Res., 17, 703 (2009).

    Article  CAS  Google Scholar 

  8. Y. M. Shin, H. Shin, and Y. M. Lim, Macromol. Res., 18, 472 (2010).

    Article  CAS  Google Scholar 

  9. I. Han, J. H. Choi, H. K. Baik, J. C. Park, J. K. Kim, J. Y. Lee, S. M. Chung, and I. S. Lee, Key Eng. Mater., 288–289, 425 (2005).

    Article  Google Scholar 

  10. C. Tendero, C. Tixier, P. Tristant, J. Desmaison, and P. Leprince, Spectrochim. Acta Part B: At. Spectrosc., 61, 2 (2006).

    Article  Google Scholar 

  11. A. Schutze, J. Y. Jeong, S. E. Babayan, J. Park, G. S. Selwyn, and R. F. Hicks, IEEE Trans. Plasma Sci., 26, 1685 (1998).

    Article  CAS  Google Scholar 

  12. M. J. Shenton and G. C. Stevens, J. Phys. D: Appl. Phys., 34, 2761 (2001).

    Article  CAS  Google Scholar 

  13. Y. P. Raizer, in Gas Discharge Physics, Y. P. Raizer, Ed., Springer-Verlag, Berlin, 1991, pp 52–75, 128–138.

    Google Scholar 

  14. L. Choi, H. K. Park, H. J. Chun, C. H. Kim, and J. W. Jang, Tissue Eng. Regen. Med., 6, 432 (2009).

    Google Scholar 

  15. A. N. Bhoj and M. J. Kushner, Plasma Sources Sci. Technol., 17, 035025 (2008).

    Article  Google Scholar 

  16. V. Anand and M. R. Gowravaram, IEEE Trans. Plasma Sci., 37, 1811 (2009).

    Article  CAS  Google Scholar 

  17. T. Takahashi, J. Z. Ruan, S. Kubota, and F. Shiraishi, Phys. Rev. A, 25, 2820 (1982).

    Article  CAS  Google Scholar 

  18. W. T. Sun, G. Li, H. P. Li, C. Y. Bao, H. B. Wang, S. Zeng, X. Gao, and H. Y. Luo, J. Appl. Phys., 101, 123302 (2007).

    Article  Google Scholar 

  19. C. Huang, Q. Yu, F.-H. Hsieh, and Y. Duan, Plasma Process. Polym., 4, 77 (2007).

    Article  CAS  Google Scholar 

  20. Q. S. Yu, C. M. Reddy, M. F. Meives, and H. K. Yasuda, J. Polym. Sci. Part A: Polym. Chem., 37, 4432 (1999).

    Article  CAS  Google Scholar 

  21. C. Z. Liu, J. Q. Wu, L. Q. Ren, J. Tong, J. Q. Li, N. Cui, N. M. D. Brown, and B. J. Meenan, Mater. Chem. Phys., 85, 340 (2004).

    Article  CAS  Google Scholar 

  22. L. J. Gerenser, J. M. Grace, G. Apai, and P. M. Thompson, Surf. Interface Anal., 29, 12 (2000).

    Article  CAS  Google Scholar 

  23. Y. H. La, H. J. Kim, I. S. Maeng, Y. J. Jung, and J. W. Park, Langmuir, 18, 301 (2002).

    Article  CAS  Google Scholar 

  24. R. Latkany, A. Tsuk, M.-S. Sheu, I.-H. Loh, and V. Trinkaus-Randall, J. Biomed. Mater. Res., 36, 29 (1997).

    Article  CAS  Google Scholar 

  25. J.-L. Dewez, A. Doren, Y.-J. Schneider, and P. G. Rouxhet, Biomaterials, 20, 547 (1999).

    Article  CAS  Google Scholar 

  26. P. A. Ramires, L. Mirenghi, A. R. Romano, F. Palumbo, and G. Nicolardi, J. Biomed. Mater. Res., 51, 535 (2000).

    Article  CAS  Google Scholar 

  27. P. Hamerli, Th. Weigel, Th. Groth, and D. Paul, Surf. Coat. Technol., 174–175, 574 (2003).

    Article  Google Scholar 

  28. H. M. Aydin, M. Turk, A. Calimli, and E. Piskin, Int. J. Artif. Organs, 29, 873 (2006).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 120-752, Korea

    Inho Han, Byeong-Ju Kwon, Barbora Vagaska, Jae Kyeong Kang, Mi Hee Lee, Hak Hee Kim & Jong-Chul Park

  2. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, 120-752, Korea

    Byeong-Ju Kwon, Barbora Vagaska, Mi Hee Lee & Jong-Chul Park

  3. Department of Chemistry, Yonsei University, Seoul, 120-752, Korea

    Bong-Jin Kim, Kang-Kyun Wang & Yong-Rok Kim

  4. Hansung Science High School, Seoul, 120-080, Korea

    Jun-Sung An, Ji-Min Lee, Chae-Young Hyun, Jae-Hwan Jeong & Soo-Jin Lim

Authors
  1. Inho Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Byeong-Ju Kwon
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Barbora Vagaska
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bong-Jin Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jae Kyeong Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mi Hee Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Hak Hee Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jong-Chul Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Kang-Kyun Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Yong-Rok Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jun-Sung An
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Ji-Min Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Chae-Young Hyun
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Jae-Hwan Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Soo-Jin Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jong-Chul Park.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Han, I., Kwon, BJ., Vagaska, B. et al. Nitrogen grafting onto polycarprolactone by a simple surface modification with atmospheric pressure glow discharge (Ar-APGD) and promoted neonatal human fibroblast growth. Macromol. Res. 19, 1134–1141 (2011). https://doi.org/10.1007/s13233-011-1108-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-011-1108-1

Keywords

Search

Navigation