Skip to main content
SpringerLink
Log in

Synthesis of visible light-induced cross-linkable chitosan as an anti-adhesive agent

  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

Visible light-induced cross-linkable chitosan was synthesized by the incorporation of furfuryl isocyanate. The synthesized chitosan derivative was analyzed by 1H NMR and GPC. The synthesized chitosan derivative showed no significant toxicity. The synthesized chitosan derivative was mixed with Rose Bengal in distilled water and irradiated with visible light for 5 min in the presence of a photomask. A micropattern that matched the micropattern of photomask was formed and the photoreactivity of the synthesized chitosan derivative was confirmed. Solidification of the synthesized chitosan is believed to have occurred by a photo-oxidation-induced cross-linking mechanism. Contact angle measurements and cell culture on the surface of solidified chitosan derivative were also carried out. Cell adhesion on the surface of solidified chitosan was not shown. Considering these results, the synthesized chitosan derivative is non-cytotoxic, solidifies rapidly by visible light not chemicals, and has fewer cell interactions. The synthesized chitosan derivative is a novel candidate for anti-adhesive agent.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Y. W. Lee, B. Chu, Y. G. Lee, N. H. Kim, J. H. Kim, K. I. Kim, and S. W. Kwon, J. Korean Surg. Soc., 76, 73 (2009).

    Article  Google Scholar 

  2. K. Falk, P. Bjorquist, M. Stromqvist, and L. Holmdahl, British J. Surg., 88, 286 (2001).

    Article  CAS  Google Scholar 

  3. H. S. Shim, Y. W. Lee, Y. M. Lee, Y. H. Oh, S. W. Kwon, J. H. Kim, and S. K. Sohn, J. Korean Surg. Soc., 63, 179 (2002).

    Google Scholar 

  4. H. J. Song, J. W. Kim, J. S. Park, Y. S. Kim, Y. S. Choi, B. G. Kim, S. J. Cha, S. J. Park, I. T. Chang, S. I. Park, E. S. Park, and S. A. Hong, J. Korean Surg. Soc., 77, 7 (2009).

    Article  Google Scholar 

  5. T. Ito and T. Matsuda, Jpn. Artif. Organs, 18, 132 (1989).

    Google Scholar 

  6. A. S. Sawhney, C. P. Pathak, and J. A. Hubbell, Macromolecules, 26, 581 (1993).

    Article  CAS  Google Scholar 

  7. K. Miyamoto, M. Sasaki, Y. Minamisawa, Y. Kurahashi, H. Kano, and S. Ishikawa, J. Biomed. Mater. Res., 70A, 550 (2004).

    Article  CAS  Google Scholar 

  8. J. Fukuda, A. Khademhosseini, Y. Yeo, X. Yang, J. Yeh, G. Eng, J. Blumling, C. Wang, D. S. Kohane, and R. Langer, Biomaterials, 27, 5259 (2006).

    Article  CAS  Google Scholar 

  9. O. Jeon, K. H. Bouhadir, J. M Mansour, and E. Alsberg, Biomaterials, 30, 2724 (2009).

    Article  CAS  Google Scholar 

  10. A. Vesperinas, J. Eastoe, P. Wyatt, I. Grilo, and R. K. Heenan, Chem. Commun., 42, 4407 (2006).

    Article  Google Scholar 

  11. Y. Nakayama, T. Kameo, A. Ohtaka, and Y. Hirano, J. Photochem. Photobiol. A:Chem., 177, 205 (2006).

    Article  CAS  Google Scholar 

  12. C. M. Elvin, A. G. Brownlee, M. G. Huson, T. A. Tebb, M. Kim, R. E. Lyons, T. Vuocolo, N. E. Liyou, T. C. Hughes, J. A. M. Ramshaw, and J. A. Werkmeister, Biomaterials, 30, 2059 (2009).

    Article  CAS  Google Scholar 

  13. Y.-W. Cho, Y.-N. Cho, S.-H. Chung, G. Yoo, and S.-W. Ko, Biomaterials, 20, 2139 (1999).

    Article  CAS  Google Scholar 

  14. A. Riccardo and A. Muzzarelli, Carbohyd. Polym., 76, 167 (2009).

    Article  Google Scholar 

  15. I.-Y. Kim, S.-J. Seo, H.-S. Moon, M.-K. Yoo, I.-Y. Park, B.-C. Kim, and C.-S. Cho, Biotechnol. Adv., 26, 1 (2008).

    Article  CAS  Google Scholar 

  16. Y. Tajima, Y. Tezuka, T. Ishii, and K. Takeuchi, Polym. J., 29, 1016 (1997).

    Article  CAS  Google Scholar 

  17. Y. Shigemitsu, Y. Tajima, M. Hoshino, Y. Tezuka, and K. Takeuchi, Jpn. J. Appl. Phys., 43, 1172 (2004).

    Article  CAS  Google Scholar 

  18. P. Ohana, D. P. Delmer, J. C. Steffens, D. E. Mattews, R. Mayer, and M. Benziman, J. Biol. Chem., 266, 13742 (1991).

    CAS  Google Scholar 

  19. H. Liu and Y. Ito, Lab Chip, 2, 175 (2002).

    Article  CAS  Google Scholar 

  20. Y. Ito and Y. Imanishi, Biomaterials, 8, 464 (1987).

    Article  CAS  Google Scholar 

  21. H. Hasuda, O. H. Kwon, I.-K. Kang, and Y. Ito, Biomaterials, 26, 2401 (2005).

    Article  CAS  Google Scholar 

  22. Y. Ito and Y. Imanishi, CRC Crit. Rev. Biocompat., 5, 45 (1989).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biotechnology, Chung-Ang University, Gyeonggi-do, 456-756, Korea

    Yoshihiro Ito

  2. Nano Medical Engineering Laboratory, Riken Advanced Science Institute, 2-1 Hirosawa, Wako-Shi, Saitama, 351-0198, Japan

    Kwang-Il Kim, Ha-Na Na & Tae-Il Son

Authors
  1. Kwang-Il Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ha-Na Na
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yoshihiro Ito
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tae-Il Son
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tae-Il Son.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, KI., Na, HN., Ito, Y. et al. Synthesis of visible light-induced cross-linkable chitosan as an anti-adhesive agent. Macromol. Res. 19, 216–220 (2011). https://doi.org/10.1007/s13233-011-0303-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-011-0303-4

Keywords

Search

Navigation