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Pregnancy Outcome in Euthyroid Women with Anti-Thyroid Peroxidase Antibodies

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Abstract

Objective

The aim of this study was to compare pregnancy outcomes in euthyroid women who were anti-TPO Ab+ with those who were anti-TPO Ab−.

Design

This observational study comprised 1,000 women in the age group of 25–35 years, having normal thyroid function tests, normotensive, non-diabetic, singleton pregnancy and attending Gyn. OPD/ANC up to 20 weeks’ gestation and those who were already in the process of abortion. anti-TPO Ab levels of >50 IU/ml were considered as anti-TPO Ab+.

Setting

This study was conducted in the SMS Medical College’s attached hospital, Jaipur from April 2012 to September 2013.

Main Outcome

The estimation of the proportion of anti-TPO Abs in the hospital-based population and the comparison of pregnancy and neonatal outcomes in anti-TPO Ab+ and Ab− euthyroid women were done.

Results

The main result showed increased rates in miscarriages (13.33 vs. 2.34 %, P < 0.001), LBWs (25 vs. 5.12 %, P < 0.001), preterm deliveries [<34 weeks] (5 vs. 1.80 %, P > 0.05) in anti-TPO Ab+ women.

Conclusions

The current study revealed that anti-TPO Abs are strongly associated with miscarriage and LBW irrespective of their gestational age. However, we did not find any correlation with the other complication as found in the studies by Abbassi-Ghanavati, Negro et al.

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Compliance with ethical requirements and conflict of interest

We ensure that accepted principles of ethical and professional conduct have been followed in this study. All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study. The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. SMS Medical College & Attached Group of Hospital, Rajasthan University of Health Science, Jaipur, Rajasthan, India

    Aruna Meena (Senior Resident) & Pushpa Nagar (Professor)

Authors
  1. Aruna Meena
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  2. Pushpa Nagar
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Corresponding author

Correspondence to Aruna Meena.

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Meena, A., Nagar, P. Pregnancy Outcome in Euthyroid Women with Anti-Thyroid Peroxidase Antibodies. J Obstet Gynecol India 66, 160–165 (2016). https://doi.org/10.1007/s13224-014-0657-6

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  • DOI: https://doi.org/10.1007/s13224-014-0657-6

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