Abstract
Objective(s)
To study the epidemiology and outcome of pregnancy complicated by obstetric cholestasis (OC).
Methods(s)
Retrospective case control study of 45 women with OC at a tertiary private hospital from November 2003 to November 2006. Statistical analysis was performed using the z test when appropriate. A p value <0.05 was considered statistically significant.
Results
The incidence of OC was 8.2%. The most common symptom was generalized pruritus which appeared after 28 weeks in 73.3% cases. The cesarean section rate was 93.3%. A higher incidence of meconium staining in amniotic fluid at delivery (17.1% vs 1.1%, p<0.005) and preterm premature rupture of membranes (8.9% vs 1.1%, p<0.01) was noted without an increase in preterm delivery rate (24.4% vs 15.6%, not significant). There was no statistically significant difference in the following parameter — pathological cardiotocography, 1–5 minute Apgar score <7, intrauterine growth restriction, neonatal intensive care admission or perinatal mortality. There was no case of postpartum hemorrhage.
Conclusion
The incidence of OC is high in the Indian population. Perinatal outcome is good in actively managed women, although at the cost of a high intervention rate.
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Padmaja, M., Bhaskar, P., Kumar, G.J. et al. A study of obstetric cholestasis. J Obstet Gynecol India 60, 225–231 (2010). https://doi.org/10.1007/s13224-010-0030-3
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DOI: https://doi.org/10.1007/s13224-010-0030-3