Abstract
Mushrooms are macroscopic fungi which can be either epigeous or hypogeous and is estimated to be 140,000 on earth, yet only 10% are known. Since ancient time, it played a diverse role in human history for mycolatry, mycophagy and as medicine in folklore and religion. Many Asian and western countries consider mushrooms as panacea for a large number of diseases and utilized for consumption as a gourmet food for its taste as well as flavor. In recent years, scientific research fraternities have confirmed that various extracts and metabolites of mushrooms used traditionally are able to treat a wide range of diseases due to their balanced modulation of multiple targets thereby providing a greater therapeutic effect or equivalent curative effect to that of modern medicine. Medicinal mushrooms especially those belonging to higher basidiomycete groups are reservoir of bioactive compounds with multiple therapeutic properties. The present review provides historical importance as well as an updated information on pharmacologically relevant higher basidiomycetes belong to the genus Agaricus, Auricularia, Phellinus, Ganoderma, Pleurotus, Trametes and Lentinus and their biologically active secondary metabolites. This will help the researchers to understand various type of secondary metabolites, their therapeutic role and related in vivo or in vitro work at a glance. The mounting evidences from several scientific community across the globe, regarding various therapeutic applications of mushroom extracts, unarguably make it an advance research area worth mass attention.
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References
Abascal K, Yarnell E (2007) A Turkey tails polysaccharide as an immunochemotherapy agent in cancer. Altern Complement Ther 13(4):178–182
Abou-Heilah AN, Kassim MY, Khaliel AS (1987) Chemical composition of the fruiting bodies of Agaricus bisporus. Phyton 47:63–68
Akagi J, Baba H (2010) PSK may suppress CD57+ T cells to improve survival of advanced gastric cancer patients. Int J Clin Oncol. 15:145–152
Al-Dbass AM, Al-Daihan SK, Bhat RS (2012) Agaricus blazei Murill as an efficient hepatoprotective and antioxidant agent against CCl4-induced liver injury in rats. Saudi J Biol Sci. 19(3):303–309
Anderson EE, Fellers CR (1942) The food value of mushrooms (Agaricus campestris). J Am Soc Hortic Sci 41:301–304
Ardigò W (2017) Healing with medicinal mushrooms. Self-Publishing via Roma, 73–73039 Tricase (LE) – Italy
Arora D (1986) Mushrooms demystified: a comprehensive guide to the fleshy fungi, 2nd edn. Ten Speed Press. ISBN 0-89815-169-4
Asatiani MD, Elisashvili V, Songulashvili G, Reznick AZ, Wasser SP (2010) Higher basidiomycetes mushrooms as a source of antioxidants. In: Progress in Mycology. Springer, Dordrecht, pp 311–326
Bach E, Hi E, Martins A, Nascimento P, Wadt N (2018) Hypoglicemic and hypolipedimic effects of Ganoderma lucidum in streptozotocin-induced diabetic rats. Medicines 5(3):78
Back KC, Carter JV, Thomas AA (1978) Occupational hazards of missile operations with special regard to the hydrazine propellants. Aviation Space Environ Med 49(4):591–598
Barua P, Adhikary RK, Kalita P, Bordoloi D, Gogol A, Singh RS, Ghosh AC (1998) Wild edible mushrooms of Meghalaya. Ancient Sci Life 17:1–4
Beaulieu M, D’Apran MB, Lacroix M (1999) Dose rate effect of γ irradiation on phenolic compounds, polyphenol oxidase, and browning of mushrooms (Agaricus bisporus). J Agric Food Chem 47(7):2537–2543
Beer JH (1993) The wrong mushroom. Diagnosis and therapy of mushroom poisoning, especially of Amanita phalloides poisoning. Schweiz Med Wochenschr 123(17):892–905
Bergendiova K, Tibenska E, Majtan J (2011) Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. Eur J Appl Physiol 111(9):2033–2040
Beuhler MC, Sasser HC, Watson WA (2009) The outcome of North American pediatric unintentional mushroom ingestions with various decontamination treatments: an analysis of 14 years of TESS data. Toxicon 53(4):437–443
Bhatt RP, Lakhanpal TN (1988) Amanita fulva (Schaeff. ex Pers.) – An edible mushroom new to India. Curr Sci 57:1126–1127
Bhatt RP, Lakhanpal TN (1989) A new record of edible Amanita from India. Curr Sci 58:627–628
Bhushan A, Kulshreshtha M (2018) The medicinal mushroom Agaricus bisporus: review of phytopharmacology and potential role in the treatment of various diseases. JNSM 1(1):4–9
Bobek P, Galbavy S (2001) Effect of pleuran (beta-glucan from Pleurotus ostreatus) on the antioxidant status of the organism and on dimethylhydrazine-induced precancerous lesions in rat colon. Br J Biomed Sci 58(3):164
Boehme J (1651) Signatura Rerum, or the signature of allthings. London. Available online at: https://archive.org/details/signaturarerumor00bhme.
Boels D, Landreau A, Bruneau C, Garnier R, Pulce C, Labadie M, de Haro L, Harry P (2014) Shiitake dermatitis recorded by French poison control centers–new case series with clinical observations. Clinic Toxicol 52(6):625–628
Bonell A (2001) Potential of fungi used in traditional Chinese medicine: Auricularia. David Moore’s world of fungi: where mycology starts Traditional Chinese Medicinal Auricularia
Bronstein AC, Spyker DA, Cantilena LR Jr, Green JL, Rumack BH, Giffin SL (2009) 2008 Annual report of the American association of poison control centers’ national poison data system (NPDS): 26th annual report. Clin Toxicol (Phila) 47(10):911–1084
Cai M, Lin Y, Luo YL, Liang HH, Sun P (2015) Extraction, antimicrobial, and antioxidant activities of crude polysaccharides from the wood ear medicinal mushroom Auricularia auricula-judae (higher basidiomycetes). Int J Med Mushrooms 17(6):591–600
Calvo MS, Mehrotra A, Beelman RB, Nadkarni G, Wang L, Cai W, Goh BC, Kalaras MD, Uribarri J (2016) A retrospective study in adults with metabolic syndrome: diabetic risk factor response to daily consumption of Agaricus bisporus (white button mushrooms). Plant Foods Hum Nutr 71(3):245–251
Chan Y, Chang T, Chan C, Yeh Y, Chen C, Shieh B, Li C (2007) Immunomodulatory effects of Agaricus blazei Murill in Balb/cByJ mice. J Microbiol Immunol Infect 40(3):201–208
Chang ST, Miles PG (1978) Historical record of the early cultivation of Lentinus in China. Mushroom J Tropics 7:31–37
Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, Tseng SF, Wu TR, Chen YY, Young JD, Lai HC (2015) Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nature Commun 7489:1–19
Chang CJ, Lin TL, Tsai YL, Wu TR, Lai WF, Lu CC, Lai HC (2019) Next generation probiotics in disease amelioration. J Food Drug Anal 7(3):615–622
Chauhan AK (2009) Textbook of molecular biotechnology. An overview. I.K. International Publishing House, New Delhi
Chen NH, Zhong JJ (2009) Ganoderic acid Me induces G1 arrest in wild-type p53 human tumor cells while G1/S transition arrest in p53-null cells. Process Biochem 44(8):928–933
Chen G, Luo YC, Ji BP, Li B, Guo Y, Li Y, Su W, Xiao ZL (2008) Effect of polysaccharide from Auricularia auricula on blood lipid metabolism and lipoprotein lipase activity of ICR mice fed a cholesterol-enriched diet. J Food Sci 73(6):H103–H108
Chen NH, Liu JW, Zhong JJ (2010) Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. Pharmacol Rep 62(1):150–163
Chen G, Luo YC, Ji BP, Li B, Su W, Xiao ZL, Zhang GZ (2011) Hypocholesterolemic effects of Auricularia auricula ethanol extract in ICR mice fed a cholesterol-enriched diet. J Food Sci Technol 48(6):692–698
Chen WY, Chang CY, Li JR, Wang JD, Wu CC, Kuan YH, Liao SL, Wang WY, Chen CJ (2018) Anti-inflammatory and neuroprotective effects of fungal immunomodulatory protein involving microglial inhibition. Int J Mol Sci 19(11):3678
Chiu WC, Yang HH, Chiang SC, Chou YX, Yang HT (2014) Auricularia polytricha aqueous extract supplementation decreases hepatic lipid accumulation and improves antioxidative status in animal model of nonalcoholic fatty liver. BioMedicine 4(2):29–38
Choudhury MB, Rahman T, Kakon AJ, Hoque N, Akhtaruzzaman M, Begum MM, Choudhuri MS, Hossain MS (2013) Effects of Pleurotus ostreatus on blood pressure and glycemic status of hypertensive diabetic male volunteers. Bangladesh J Med Biochem 6(1):5–10
Corazza M, Zauli S, Ricci M, Borghi A, Pedriali M, Mantovani L, Virgili A (2015) Shiitake dermatitis: toxic or allergic reaction? J Eur Acad Dermatol Venereol 29(7):1449–1451
Cui L, Sun Y, Xu H, Xu H, Cong H, Liu J (2013) A polysaccharide isolated from Agaricus blazei Murill (ABP-AW1) as a potential Th1 immunity-stimulating adjuvant. Oncol Lett 6(4):1039–1044
de Miranda AM, Ribeiro GM, Cunha AC, Silva LS, dos Santos RC, Pedrosa ML, Silva ME (2014) Hypolipidemic effect of the edible mushroom Agaricus blazei in rats subjected to a hypercholesterolemic diet. J PhysiolBiochem 70(1):215–224
Dhanasekaran D, Latha S, Saha S, Thajuddin N, Panneerselvam A (2013) Extracellular biosynthesis, characterisation and in-vitro antibacterial potential of silver nanoparticles using Agaricus bisporus. J Exp Nanosci 8(4):579–588
Diaz JH (2018) Amatoxin-containing mushroom poisonings: species, toxidromes, treatments, and outcomes. Wilderness Environ Med 29(1):111–118
Dou M, Di L, Zhou LL, Yan YM, Wang XL, Zhou FJ, Yang ZL, Li RT, Hou FF, Cheng YX (2014) Cochlearols A and B, polycyclic meroterpenoids from the fungus Ganoderma cochlear that have renoprotective activities. Organ Lett 16(23):6064–6067
Dugan FM (2008) Fungi, folkways and fairy tales: Mushrooms & mildews in stories, remedies & rituals, from Oberon to the internet. North Am Fungi 3(7):23–72
Endo M, Beppu H, Akiyama H, Wakamatsu K, Ito S, Kawamoto Y, Shimpo K, Sumiya T, Koike T, Matsui T (2010) Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells. Biochimica et Biophysica Acta (BBA) General Subj 1800(7):669–673
Firenzuoli F, Gori L, Lombardo G (2008) The medicinal mushroom Agaricus blazei Murrill: review of literature and pharmaco-toxicological problems. Evid Based Complement Altern Med 5(1):3–15
Fu Z, Liu Y, Zhang Q (2016) A potent pharmacological mushroom: Pleurotus eryngii. Fungal Genom Biol 6(1):1–5
Gallego Domínguez S, Santisteban S, LuengoÁlvarez J, González Castillo P, CastellanoCerviño I (2008) Acute renal failure after intake of mushrooms: the orellanus syndrome. Nefrología (Engl Ed) 28(3):351–352
Gao Y, Zhou S, Jiang W, Huang M, Dai X (2003) Effects of Ganopoly® (A Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Investig 32(3):201–215
Gao Y, Lan J, Dai X, Ye J, Zhou S (2004) A phase I/II study of Ling Zhi mushroom Ganoderma lucidum (W. Curt.: Fr.) Lloyd (Aphyllophoromycetideae) extract in patients with type II diabetes mellitus. Int J Med Mushrooms 6(1):33–40
Garcia MA, Alonso J, Fernández MI, Melgar MJ (1998) Lead content in edible wild mushrooms in northwest Spain as indicator of environmental contamination. Arch Environ Contam Toxicol 34(4):330–335
Gill BS, Kumar S (2016) Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study. Tumor Biol 37(10):14271–14290
Gonzaga ML, Menezes TM, de Souza JR, Ricardo NM, Freitas AL, Soares SD (2013) Analgesic activity of a glucan polysaccharide isolated from Agaricus blazei Murill. Int J Carbohydr Chem 2013:1–7
Grothe T, Stadler M, Köpcke B, Roemer E, Bitzer J, Wabnitz P, Küper T, Inventors; Grothe Dr Torsten, Stadler Prof Dr Marc, Assignee (2016) Terpenoid spiro ketal compounds with LXR agonists activity, their use and formulations with them. United States patent US 9,453,016. 2016 Sep 27
Guo JY, Han CC, Liu YM (2010) A contemporary treatment approach to both diabetes and depression by cordyceps sinensis, Rich in Vanadium. Evid Based Complement Altern Med 7(3):387–389
Gupta A, Kirar V, Keshri GK, Gola S, Yadav A, Negi PS, Misra K (2014) Wound healing activity of an aqueous extract of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher basidiomycetes). Int J Med Mushrooms 16(4):345–354
Gurunathan S, Raman J, Malek SN, John PA, Vikineswary S (2013) Green synthesis of silver nanoparticles using Ganoderma neo-japonicumImazeki: a potential cytotoxic agent against breast cancer cells. Int J Nanomed 8:4399–4413
Haberl B, Pfab R, Berndt S et al (2011) Case series: alcohol intolerance with Coprin-like syndrome after consumption of the mushroom Lepiotaaspera (Pers.:Fr.) Quel., 1886 (Freckled Dapperling). ClinToxicol 49(2):113–114
Hamzah AA, Keow CK, Syazri A, Mallhi TH, Khan AH, Khan YH (2017) Mushroom bezoar causing small bowel obstruction. J Coll Physicians Surg Pak 27:S13–S15
Han XQ, Yue GL, Yue RQ, Dong CX, Chan CL, Ko CH, Cheung WS, Luo KW, Dai H, Wong CK, Leung PC (2014) Structure elucidation and immunomodulatory activity of a beta glucan from the fruiting bodies of Ganoderma sinense. PloS One 9(7):e100380
Harsh NSK, Rai BK, Ayachi SS (1993) Forest fungi and tribal economy – a case study in Baiga tribe of Madhya Pradesh, India. J Trop For 9:270–279
Harsh NSK, Tiwari CK, Rai BK (1996) Forest fungi in the aid of tribal women of Madhya Pradesh, India. Sustain For 1:10–15
Harsh NSK, Rai BK, Soni VK (1999) Some ethnomycological studies from Madhya Pradesh, India. In: Singh J, Aneja KR (eds) From ethnomycology to fungal biotechnology. Platinum Press, New York, USA, pp 19–31
Hetland G, Johnson E, Lyberg T, Kvalheim G (2011) The mushroom Agaricus blazei Murill elicits medicinal effects on tumor, infection, allergy, and inflammation through its modulation of innate immunity and amelioration of Th1/Th2 imbalance and inflammation. Adv Pharmacol Sci 2011:1–10
Hetland G, Eide DM, Tangen JM, Haugen MH, Mirlashari MR, Paulsen JE (2016) The Agaricus blazei-based mushroom extract, Andosan™, protects against intestinal tumorigenesis in the A/J Min/+ Mouse. PloS One 11(12):e0167754
Hobbs C (2004) Medicinal value of turkey tail fungus Trametes versicolor (L.: Fr.) Pilát (Aphyllophoromycetideae). A literature review. Int J Med Mushrooms 6(3):1–18
Horowitz KM, Horowitz BZ (2019) Gyromitra mushroom toxicity. StatPearls Publishing
Hossen M, Billah Prince M, Tanvir EM, Chowdhury M, Rahman M, Alam F, Paul S, Saha M, Ali M, Bhoumik NC, Karim N (2018) Ganoderma lucidum and Auricularia polytricha mushrooms protect against carbofuran-induced toxicity in rats. Evid Based Complement Alternat Med 2018:1–13
Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P (2007) The mushroom Agaricus blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 13(1):97–102
Hsu SC, Ou CC, Li JW, Chuang TC, Kuo HP, Liu JY, Chen CS, Lin SC, Su CH, Kao MC (2008) Ganodermatsugae extracts inhibit colorectal cancer cell growth via G2/M cell cycle arrest. J Ethnopharmacol 120(3):394–401
Hsin MC, Hsieh YH, Wang PH, Ko JL, Hsin IL, Yang SF (2017) Hispolon suppresses metastasis via autophagic degradation of cathepsin S in cervical cancer cells. Cell Death Disease 8(10):e3089
Hsin IL, Hsu JC, Wu WJ, Lu HJ, Wu MF, Ko JL (2018) GMI, a fungal immunomodulatory protein from Ganoderma microsporum, induce apoptosis via β-catenin suppression in lung cancer cells. Environ Toxicol 33(9):955–961
Huang GJ, Deng JS, Huang SS, Hu ML (2011a) Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation. J Agric Food Chem 59(13):7104–7113
Huang GJ, Hsieh WT, Chang HY, Huang SS, Lin YC, Kuo YH (2011b) α-Glucosidase and aldose reductase inhibitory activities from the fruiting body of Phellinus merrillii. J Agric Food Chem. 59(10):5702–5706
Huang HY, Korivi M, Chaing YY, Chien TY, Tsai YC (2012) Pleurotus tuber-regium polysaccharides attenuate hyperglycemia and oxidative stress in experimental diabetic rats. Evid Based Complement Alternat Med 2012:1–8
Huang S, Mao J, Ding K, Zhou Y, Zeng X, Yang W, Wang P, Zhao C, Yao J, Xia P, Pei G (2017) Polysaccharides from Ganoderma lucidum promote cognitive function and neural progenitor proliferation in mouse model of Alzheimer’s disease. Stem cell reports. 8(1):84–94
Hwang HJ, Kim SW, Lim JM, Joo JH, Kim HO, Kim HM, Yun JW (2005) Hypoglycemic effect of crude exopolysaccharides produced by a medicinal mushroom Phellinus baumii in streptozotocin-induced diabetic rats. Life Sci 76(26):3069–3080
Hwang JS, Kwon HK, Kim JE, Rho J, Im SH (2012) Immunomodulatory effect of water soluble extract separated from mycelium of Phellinus linteus on experimental atopic dermatitis. BMC Complem Altern Med 12(1):159:1-11
Ikekawa T, Uehara N, Maeda Y, Nakanishi M, Fukuoka F (1969) Antitumor activity of aqueous extracts of edible mushrooms. Cancer Res 29(3):734–735
Im KH, Choi J, Baek SA, Lee TS (2018) Hyperlipidemic inhibitory effects of Phellinus pini in rats fed with a high fat and cholesterol diet. Mycobiology 46(2):1–9
Itoh H, Ito H, Hibasami H (2008) Blazein of a new steroid isolated from Agaricus blazei Murrill (himematsutake) induces cell death and morphological change indicative of apoptotic chromatin condensation in human lung cancer LU99 and stomach cancer KATO III cells. Oncol Rep 20(6):1359–1361
Ivone HA, Jorge MT, Guadalupe GR, Berenice YJ (2016) Total polyphenols and antioxidant activity of Ganoderma curtisii extracts. J of Med Plants Studies 4(4):136–141
Jedinak A, Sliva D (2008) Pleurotus ostreatus inhibits proliferation of human breast and colon cancer cells through p53-dependent as well as p53-independent pathway. Int J Oncol 33(6):1307–1313
Jeong SC, Koyyalamudi SR, Jeong YT, Song CH, Pang G (2012) Macrophage immunomodulating and antitumor activities of polysaccharides isolated from Agaricus bisporus white button mushrooms. J Med Food 15(1):58–65
Jesenak M, Majtan J, Rennerova Z, Kyselovic J, Banovcin P, Hrubisko M (2013) Immunomodulatory effect of pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Int Immunopharmacol 15(2):395–399
Jesenak M, Hrubisko M, Majtan J, Rennerova Z, Banovcin P (2014) Anti-allergic effect of Pleuran (β-glucan from Pleurotus ostreatus) in children with recurrent respiratory tract infections. Phytother Res 28(3):471–474
Jiang L, Yu Z, Lin Y, Cui L, Yao S, Lv L, Liu J (2018) Low-molecular-weight polysaccharides from Agaricus blazei Murrill modulate the Th1 response in cancer immunity. Oncol Lett 15(3):3429–3436
Jin X, Ruiz Beguerie J, Sze DM, Chan GC (2012) Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD007731.pub2
Jogaiah S, Kurjogi M, Abdelrahman M, Hanumanthappa N, Tran LS (2017) Ganoderma applanatum-mediated green synthesis of silver nanoparticles: structural characterization, and in vitro and in vivo biomedical and agrochemical properties. Arab J Chem. https://doi.org/10.1016/j.arabjc.2017.12.002
Kang IS, Kim RI, Kim GS, Kim NR, Shin JY, Kim C (2015) Effects of Agaricus blazei Murill water extract on immune response in BALB/c mice. J Korean Soc Food Sci Nutr 44(11):1629–1636
Karsten P (1881) Enumeratio Boletinearumet Polyporearum Fennicarum Systemate novo dispositarum. Revue de Mycologie 3:16–19
Karwa A, Rai MK (2010) Tapping into the edible fungi biodiversity of Central India. Biodiversitas 11:97–101
Kaufer F (1936) The biology of Pleurotus corticatus fries. Minnesota agricultural experiment station bulletin 114
Kaul TN (1993) Conservation of mushroom resources in India. Mushroom Res 2:11–18
Kaul TN, Kachroo JL (1974) Common edible mushrooms of Jammu and Kashmir. Ind Mush Sci 71:26–31
Kavyani A, Shahne Az, Pourreza J, Haji-Abadi Sm, Nikkhah M, Landy N (2014) Efficiency of different levels of mushroom (Agaricus bisporus) on intestinal morphology and microflora of broiler chickens. J Farm Anim Nutr Physiol 9:23–30
Kim YW, Kim KH, Choi HJ, Lee DS (2005) Anti-diabetic activity of β-glucans and their enzymatically hydrolyzed oligosaccharides from Agaricus blazei. Biotechnol Lett 27(7):483–487
Kim HM, Kang JS, Kim JY, Park SK, Kim HS, Lee YJ, Yun J, Hong JT, Kim Y, Han SB (2010) Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse. Int Immunopharmacol 10(1):72–78
Kim JH, Kim YC, Park B (2016) Hispolon from Phellinus linteus induces apoptosis and sensitizes human cancer cells to the tumor necrosis factor-related apoptosis-inducing ligand through upregulation of death receptors. Oncol Rep 35(2):1020–1026
Knechtges DR (1996) Wen Xuan or selections of refined literature, vol 3. Princeton University Press, pp 201–211
Knežević A, Stajić M, Sofrenić I, Stanojković T, Milovanović I, Tešević V, Vukojević J (2018) Antioxidative, antifungal, cytotoxic and antineurodegenerative activity of selected Trametes species from Serbia. PloS One 13(8):1–18
Ko C (1993) Clinical symptomatology and management of mushroom poisoning. Toxicon 31(12):1513–1540
Kodiyalmath JK, Krishnappa M (2017) Evaluation of antimicrobial activity of Phellinus linteus (Berk. & MA Curtis.) with their wild collections from Western Ghats of India. Trop Plant Res 4(2):351–357
Kojima H, Tanigawa N, Kariya S, Komemushi A, Shomura Y, Sawada S, Arai E, Yokota Y (2006) A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases. Radiat Med 24:139–142
Konno S, Chu K, Feuer N, Phillips J, Choudhury M (2015) Potent anticancer effects of bioactive mushroom extracts (Phellinus linteus) on a variety of human cancer cells. J Clinic Med Res 7(2):76–82
Krupodorova T, Rybalko S, Barshteyn V (2014) Antiviral activity of basidiomycete mycelia against influenza type A (serotype H1N1) and herpes simplex virus type 2 in cell culture. Virol Sin 29(5):284–290
Lai CY, Hung JT, Lin HH, Alice LY, Chen SH, Tsai YC, Shao LE, Yang WB, Yu J (2010) Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro. Vaccine 28(31):4945–4954
Lee YH, Kim JH, Song CH, Jang KJ (2016) Ethanol extract of Ganoderma lucidum augments cellular anti-oxidant defense through activation of Nrf2/HO-1. J Pharmacopunct 19(1):59
Lheureux P, Penaloza A, Gris M (2005) Pyridoxine in clinical toxicology: a review. Eur J Emerg Med 12(2):78–85
Li SZ, Mu BCG (2004) People’s medical publishing house. Beijing
Li CH, Chen PY, Chang UM, Kan LS, Fang WH, Tsai KS, Lin SB (2005) Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells. Life Sci 77(3):252–265
Li F, Zhang Y, Zhong Z (2011) Antihyperglycemic effect of Ganoderma lucidum polysaccharides on streptozotocin-induced diabetic mice. Int J Mol Sci 12(9):6135–6145
Liu RM, Zhong JJ (2011) Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. Phytomedicine 18(5):349–355
Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R (2009) Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. Bioorg Med Chem Lett 19(8):2154–2157
Liu RM, Li YB, Zhong JJ (2012) Cytotoxic and pro-apoptotic effects of novel ganoderic acid derivatives on human cervical cancer cells in vitro. Eur J Pharmacol 681(1–3):23–33
Liu J, Jia L, Kan J, Jin CH (2013) In vitro and in vivo antioxidant activity of ethanolic extract of white button mushroom (Agaricus bisporus). Food Chem Toxicol. 51:310–316
Liu C, Dunkin D, Lai J, Song Y, Ceballos C, Benkov K, Li XM (2015a) Anti-inflammatory effects of Ganoderma lucidum triterpenoid in human crohn’sdisease associated with downregulation of NF-κB signaling. Inflamm Bowel Diseases 21(8):1918–1925
Liu Y, Zhang L, Zhu X, Wang Y, Liu W, Gong W (2015b) Polysaccharide Agaricus blazei Murill stimulates myeloid derived suppressor cell differentiation from M2 to M1 type, which mediates inhibition of tumour immune-evasion via the Toll-like receptor 2 pathway. Immunology 146(3):379–391
Lu A, Yu M, Shen M, Fang Z, Xu Y, Wang S, Zhang Y, Wang W (2018) Antioxidant and anti-diabetic effects of Auricularia auricular polysaccharides and their degradation by artificial gastrointestinal digestion-bioactivity of Auricularia auricular polysaccharides and their hydrolysates. Acta Sci Pol Technol Aliment 17(3):277–288
Łukasik-Głebocka M, Druzdz A, Naskret M (2011) Clinical symptoms and circumastances of acute poisonings with fly agaric (Amanita muscaria) and panther cap (Amanita pantherina). Prz Lek 68(8):449–452
Ma Y, Wang C, Zhang Q, Peng X, Feng Y, Meng X (2018) The effects of polysaccharides from Auricularia auricula (Huaier) in adjuvant anti-gastrointestinal cancer therapy: a systematic review and network meta-analysis. Pharmacol Res 132:80–89
Marmion VJ, Wiedemann TE (2002) The death of Claudius. J Royal Soc Med 95(5):260–261
Matijašević D, Pantić M, Rašković B, Pavlović V, Duvnjak D, Sknepnek A, Nikšić M (2016) The antibacterial activity of Coriolus versicolor methanol extract and its effect on ultrastructural changes of Staphylococcus aureus and Salmonella enteritidis. Front Microbiol 7(1226):1–15
Mau JL, Wu KT, Wu YH, Lin YP (1998) Nonvolatile taste components of ear mushrooms. J Agric Food Chem. 46(11):4583–4586
Mau JL, Chao GR, Wu KT (2001) Antioxidant properties of methanolic extracts from several ear mushrooms. J Agric Food Chem 49:5461–5467
Meydani M (1999) Dietary antioxidants modulation of aging and immune-endothelial cell interaction. Mech Ageing Dev 111(2–3):123–132
Misaki A, Kakuta M (1995) Kikurage (tree-ear) and Shirokikurage (white jelly-leaf): Auricularia auricula and Tremella fuciformis. Food Rev Int 11(1):211–218
Mizuno M, Minato KI, Ito H, Kawade M, Terai H, Tsuchida H (1999) Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. IUBMB Life 47(4):707–714
Monnier L, Grimaldi A, Charbonnel B, Iannascoli F, Lery T, Garofano A, Childs M (2004) Management of French patients with type 2 diabetes mellitus in medical general practice: report of the Mediab observatory. Diabetes Metab 30(1):35–42
Mori S, Nakagawa-Yoshida K, Tsuchihashi H, Koreeda Y, Kawabata M, Nishiura Y, Ando M, Osame M (1998) Mushroom worker’s lung resulting from indoor cultivation of Pleurotus osteatus. Occup Med 48(7):465–468
Nam SW, Han JY, Kim JI, Park SH, Cho SH, Han NI, Yang JM, Kim JK, Choi SW, Lee YS, Chung KW, Sun HS (2005) Spontaneous regression of a large hepatocellular carcinoma with skull metastasis. J Gastroenterol Hepatol 20:488–492
Noh JR, Lee IK, Ly SY, Yang KJ, Gang GT, Kim YH, Hwang JH, Yun BS, Lee CH (2011) A Phellinus baumii extract reduces obesity in high-fat diet-fed mice and absorption of triglyceride in lipid-loaded mice. J Med Food 14(3):209–218
Norris SL, Lau J, Smith SJ, Schmid CH, Engelgau MM (2002) Self-management education for adults with type 2 diabetes: a meta-analysis of the effect on glycemic control. Diabetes Care 25(7):1159–1171
Osińska-Jaroszuk M, Jaszek M, Mizerska-Dudka M, Błachowicz A, Rejczak TP, Janusz G, Wydrych J, Polak J, Jarosz-Wilkołazka A, Kandefer-Szerszeń M (2014) Exopolysaccharide from Ganoderma applanatum as a promising bioactive compound with cytostatic and antibacterial properties. BioMed Res Int 2014:1–10
Panda MK, Tayung KU (2015) Documentation and ethnomedicinal knowledge on wild edible mushrooms among ethnic tribes of northern Odisha, India. Asian J Pharm Clin Res 8(4):139–143
Park NS, Lee KS, Sohn HD, Kim DH, Lee SM, Park E, Kim I, Je YH, Jin BR (2005) Mycologia 97(1):130–138
Paterson RR (2006) Ganoderma–a therapeutic fungal biofactory. Phytochemistry 67(18):1985–2001
Peng XR, Liu JQ, Wang CF, Li XY, Shu Y, Zhou L, Qiu MH (2014) Hepatoprotective effects of triterpenoids from Ganoderma cochlear. J Nat Prod 77(4):737–743
Pezzella C, Macellaro G, Sannia G, Raganati F, Olivieri G, Marzocchella A, Schlosser D, Piscitelli A (2017) Exploitation of trametes versicolor for bioremediation of endocrine disrupting chemicals in bioreactors. PloS One 12(6):e0178758:1–e0178758:12
Pires AD, Ruthes AC, Cadena SM, Iacomini M (2017) Cytotoxic effect of a mannogalactoglucan extracted from Agaricus bisporus on HepG2 cells. Carbohydr Polym 170:33–42
Polosmak N (2010) We drank Soma, we became immortal. Sci Firsthand 26:63–71
Pozzilli P, Guglielmi C (2009) Double diabetes: a mixture of type 1 and type 2 diabetes in youth. Endocr Dev 14:151–166
Purkayastha RP, Chandra A (1985) Manual of Indian edible mushrooms. Today and Tomorrows Printers and Publishers, New Delhi, pp 192–194
Puttaraju NG, Venkateshaiah SU, Dharmesh SM, Urs SM, Somasundaram R (2006) Antioxidant activity of indigenous edible mushrooms. J Agric Food Chem 54:9764–9772
Qiao J, Dou Z, Feng WU, Meng G, Chen H, Zheng H (2014) Effect of combination of Ganoderma lucidum polysaccharide and metformin on AGEs and CTGF of cardiac muscle in type 2 diabetic rats and the mechanism. Chin Pharmacol Bull 4:536–541
Rai BK, Ayachi SS, Rai A (1993) A note on ethno−myco−medicines from Central India. Mycologist. 7:192–193
Rai M, Tidke G, Wasser SP (2005) Therapeutic potential of mushrooms. Nat Prod Radian 4(4):246–257
Ramoutsaki IA, Ramoutsakis IA, Papadakis CE, Helidonis ES (2002) Therapeutic methods used for otolaryngological problems during the Byzantine period. Ann Otol Rhinol Laryngol 111(6):553–557
Rathee S, Rathee D, Rathee D, Kumar V, Rathee P (2012) Mushrooms as therapeutic agents. Revista Bras de Farmacogn 22(2):459–474
Reza MA, Hossain MA, Lee SJ, Yohannes SB, Damte D, Rhee MH, Jo WS, Suh JW, Park SC (2014) Dichlormethane extract of the jelly ear mushroom Auricularia auricula-judae (higher basidiomycetes) inhibits tumor cell growth in vitro. Int J Med Mushrooms 16(1):37–47
Ricciardi MR, Licchetta R, Mirabilii S, Scarpari M, Parroni A, Fabbri AA, Cescutti P, Reverberi M, Fanelli C, Tafuri A (2017) Preclinical antileukemia activity of tramesan: a newly identified bioactive fungal metabolite. Oxid Med Cell Longev. https://doi.org/10.1155/2017/5061639
Rosenbloom AL, Joe JR, Young RS, Winter WE (1999) Emerging epidemic of type 2 diabetes in youth. Diabetes Care 22(2):345–354
Roupas P, Keogh J, Noakes M, Margetts C, Taylor P (2012) The role of edible mushrooms in health: evaluation of the evidence. J Funct Foods 4(4):687–709
Sagar A, Chauhan A, Sehgal AK (2005) Ethnobotanical study of some wild edible mushrooms of tribal district Kinnaur of Himachal Pradesh. Indian J Mushroom 23:1–8
Santi L, Maggioli C, Mastroroberto M, Tufoni M, Napoli L, Caraceni P (2012) Acute liver failure caused by Amanita phalloides poisoning. Int J Hepatol. https://doi.org/10.1155/2012/487480
Satyavati G (2008) Ayurvedic concepts of nutrition and dietary guidelines for promoting/preserving health and longevity. Nutrition Foundation of India, New Delhi, pp 210–228
Schneider I, Kressel G, Meyer A, Krings U, Berger RG, Hahn A (2011) Lipid lowering effects of oyster mushroom (Pleurotus ostreatus) in humans. J Func Foods 3(1):17–24
Sekara A, Kalisz A, Grabowska A, Siwulski M (2015) Auricularia spp.-mushrooms as novel food and therapeutic agents-a review. Sydowia 67:1
Semwal KC, Stephenson SL, Bhatt VK, Bhatt RP (2014) Edible mushrooms of the Northwestern Himalaya, India: a study of indigenous knowledge, distribution and diversity. Mycosphere 5(3):440–461
Senti G, Leser C, Lundberg M, Wuthrich B (2000) Allergic asthma to shiitake and oyster mushroom. Allergy 55(10):975–976
Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, Yu PH, Leung GP, Ngai SM, Yeung JH, Leung PS (2009) Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+ db/+ db) mice. Phytomedicine 16(5):426–436
Sharda RM, Kaushal SC, Negi GS (1997) Edible fungi of Garhwal−Himalaya. Mushroom Res 6:11–14
Sharma YK, Doshi A (1996) Some studies on an edible wild fungus Phellorinia inquinans, in Rajasthan, India. Mushroom Res 5:51–53
Sheu F, Chien PJ, Hsieh KY, Chin KL, Huang WT, Tsao CY (2009) Purification, cloning, and functional characterization of a novel immunomodulatory protein from Antrodia camphorata (bitter mushroom) that exhibits TLR2-dependent NF-kappaB activation and M1 polarization within murine macrophages. J Agric Food Chem 57:4130–4141
Shi Y, Cai D, Wang X, Liu X (2012) Immunomodulatory effect of Ganoderma lucidum polysaccharides (GLP) on long-term heavy-load exercising mice. Int J Vitam Nutr Res 82(6):383–390
Shibata Y, Kurita S, Okugi H, Yamanaka H (2004) Dramatic remission of hormone refractory prostate cancer achieved with extract of the mushroom. Phellinus linteus. Urol Int 73:188–190
Shimizu T, Kawai J, Ouchi K, Kikuchi H, Osima Y, Hidemi R (2016) Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells. Int J Oncol 48(4):1670–1678
Singh SK, Rawat GS (2000) Morel mushroom industry in India. Plant Talk 21:36–37
Smiderle FR, Ruthes AC, van Arkel J, Chanput W, Iacomini M, Wichers HJ, Van Griensven LJ (2011) Polysaccharides from Agaricus bisporus and Agaricus brasiliensis show similarities in their structures and their immunomodulatory effects on human monocytic THP-1 cells. BMC Complement Altern Med 11(1):1–10
Song M, Park HJ (2014) Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages. J Ethnopharmacol 154(2):311–318
Song YS, Kim SH, Sa JH, Jin C, Lim CJ, Park EH (2004) Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum. J Ethnopharmacol 90(1):17–20
Standish LJ, Wenner CA, Sweet ES, Bridge C, Nelson A, Martzen M, Novack J, Torkelson C (2008) Trametes versicolor mushroom immune therapy in breast cancer. J Soc Integr Oncol 6(3):122–128
Staniszewska J, Szymański M, Ignatowicz E (2017) Antitumor and immunomodulatory activity of Inonotus obliquus. Herba Polonica 63(2):48–58
Su J, Cao XXB (1981) Anhui Science & Technology Publishing House. Hefei
Suabjakyong P, Saiki R, Van Griensven LJ, Higashi K, Nishimura K, Igarashi K, Toida T (2015) Polyphenol extract from Phellinus igniarius protects against acrolein toxicity in vitro and provides protection in a mouse stroke model. PloS One 10(3):e0122733:1–e0122733:14
Tang W, Liu JW, Zhao WM, Wei DZ, Zhong JJ (2006) Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci 80(3):205–211
Tangen JM, Tierens A, Caers J, Binsfeld M, Olstad OK, Trøseid AM, Wang J, Tjønnfjord GE, Hetland G (2015) Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomize, double blinded clinical study. Biomed Res Int 2015:1–11
Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E (2016) Effect of the medicinal Agaricus blazei Murill-based mushroom extract, AndoSanTM, on symptoms, fatigue and quality of life in patients with Crohn’s disease in a randomized single-blinded placebo controlled study. PloS One 11(7):e0159288:1–e0159288:17
Tie L, Yang HQ, An Y, Liu SQ, Han J, Xu Y, Hu M, Li WD, Chen AF, Lin ZB, Li XJ (2012) Ganoderma lucidum polysaccharide accelerates refractory wound healing by inhibition of mitochondrial oxidative stress in type 1 diabetes. Cell Physiol Biochem 29(3–4):583–594
Torkelson CJ, Sweet E, Martzen MR, Sasagawa M, Wenner CA, Gay J, Putiri A, Standish LJ (2012) Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncol 2012:1–7
Toth B, Erickson J, Gannett P, Patil K (1997) Carcinogenesis by the cultivated baked Agaricus bisporus mushroom in mice. Oncol Rep 4(5):931–936
Tran HH, Juergens AL (2019) Mushroom toxicity. StatPearls Publishing
Tuli HS, Sandhu SS, Sharma AK (2014) Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech 4(1):1–2
Twardowski P, Kanaya N, Frankel P, Synold T, Ruel C, Pal SK, Junqueira M, Prajapati M, Moore T, Tryon P, Chen S (2015) A phase I trial of mushroom powder in patients with biochemically recurrent prostate cancer: roles of cytokines and myeloid-derived suppressor cells for Agaricus bisporus–induced prostate-specific antigen responses. Cancer 121(17):2942–2950
Vaidya JG, Rabba AS (1993) Fungi in folk medicine. Mycologist 7(3):131–133
Valverde ME, Hernández-Pérez T, Paredes-López O (2015) Edible mushrooms: improving human health and promoting quality life. Int J Food Microbiol 2015:1–14
Volman JJ, Mensink RP, Van Griensven LJ, Plat J (2010) Effects of α-glucans from Agaricus bisporus on ex vivo cytokine production by LPS and PHA-stimulated PBMCs; a placebo-controlled study in slightly hypercholesterolemic subjects. Eur J Clin Nutr 64(7):720–726
Wachtel-Galor S, Szeto YT, Tomlinson B, Benzie IF (2004a) Ganoderma lucidum (‘Lingzhi’); acute and short-term biomarker response to supplementation. Int J Food Sci Nutr 55(1):75–83
Wachtel-Galor S, Tomlinson B, Benzie IF (2004b) Ganoderma lucidum (‘Lingzhi’), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr 91(2):263–269
Wang G, Zhao J, Liu J, Huang Y, Zhong JJ, Tang W (2007) Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. Int Immunopharmacol 7(6):864–870
Wang SJ, Li YX, Bao L, Han JJ, Yang XL, Li HR, Wang YQ, Li SJ, Liu HW (2012) Eryngiolide A, a cytotoxic macrocyclic diterpenoid with an unusual cyclododecane core skeleton produced by the edible mushroom Pleurotuseryngii. Organ Lett 14(14):3672–3675
Wang WH, Wu FH, Yang Y, Wu N, Zhang JS, Feng N, Tang CH (2015) Hypoglycemic effect of ethanol and ethyl acetate extract of Phellinus baumii fruiting body in streptozotocin-induced diabetic mice. Evid Based Complement Alternat Med 2015:1–7
Wang X, Sun D, Tai J, Wang L (2017) Ganoderic acid A inhibits proliferation and invasion, and promotes apoptosis in human hepatocellular carcinoma cells. Mol Med Rep 16(4):3894–3900
Wani BA, Bodha RH, Wani AH (2010) Nutritional and medicinal importance of mushrooms. J Med Plants Res 4(24):2598–2604
Williamson D, Pandey S, Taylor S, Rogers K, Storey L, Marshall MR, Holland D (2011) A case of infection caused by the basidiomycete Phellinus undulatus. J Med Microbiol 60(2):256–258
Winkelmann M, Borchard F, Stangel W, Grabensee B (1982) Fatal immuno haemolytic anaemia after eating the mushroom Paxillus involutus (author’s transl). Deutsche Medizinische Wochenschrift (in German) 107(31–32):1190–1194
Wisbeck E, Facchini JM, Alves EP, Silveira ML, Gern RM, Ninow JL, Furlan SA (2017) A polysaccharide fraction extracted from Pleurotus ostreatus mycelial biomass inhibit Sarcoma 180 tumor. Anais da Academia Brasileira de Ciências 89(3):2013–2020
Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, Zhong ZF, Xu ZT, Chen XP, Wang YT (2012) Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia 83(2):408–414
Xiao GL, Liu FY, Chen ZH (2003) Clinical observation on treatment of Russula subnigricans poisoning patients by Ganoderma lucidum decoction. Zhongguo Zhong Xi Yi Jie He Za Zhi 23:278–280
Xiao C, Wu QP, Cai W, Tan JB, Yang XB, Zhang JM (2012) Hypoglycemic effects of Ganoderma lucidum polysaccharides in type 2 diabetic mice. Arch Pharm Res 35(10):1793–1801
Xiao C, Wu Q, Zhang J, Xie Y, Cai W, Tan J (2017) Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice. J Ethnopharmacol 196:47–57
Xu H, Kong YY, Chen X, Guo MY, Bai XH, Lu YJ, Li W, Zhou XW (2016) Recombinant FIP-gat, a fungal immunomodulatory protein from Ganoderma atrum, induces growth inhibition and cell death in breast cancer cells. J Agric Food Chem 64(13):2690–2698
Yang S (1998) The divine farmer’s materia medica: a translation of the Shen Nong Ben Cao Jing. Blue Poppy Press, Boulder, CO
Yang M, Chen Z, Kwok S, Ge H (1993) The antitumor effect of purified PSP Coriolus versicolor, (PCV) in vitro and in vivo. In: Proceedings of the PSP international symposium. Fudan University Press, pp 80–96
Yang Y, Zhou H, Liu W, Wu J, Yue X, Wang J, Quan L, Liu H, Guo L, Wang Z, Lian X (2018) Ganoderic acid A exerts antitumor activity against MDA-MB-231 human breast cancer cells by inhibiting the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. Oncol Lett 16(5):6515–6521
Younis AM, Wu FS, El Shikh HH (2015) Antimicrobial activity of extracts of the oyster culinary medicinal mushroom Pleurotus ostreatus (higher basidiomycetes) and identification of a new antimicrobial compound. Int J Med Mushrooms 17(6):579–590
Yu J, Sun R, Zhao Z, Wang Y (2014) Auricularia polytricha polysaccharides induce cell cycle arrest and apoptosis in human lung cancer A549 cells. Int J Biol Macromol 68:67–71
Yue GG, Fung KP, Tse GM, Leung PC, Lau CB (2006) Comparative studies of various Ganoderma species and their different parts with regard to their antitumor and immunomodulating activities in vitro. J Altern Complement Med 12(8):777–789
Zaidi KU, Ali SA, Ali AS (2016) Effect of purified mushroom tyrosinase on melanin content and melanogenic protein expression. Biotechnol Res Int 2016:1–8
Zent EL (2008) Mushrooms for Life among the Jotï in the Venezuelan Guayana. Econ Bot 62(3):471–481
Zhang HN, Lin ZB (2004) Hypoglycemic effect of Ganoderma lucidum polysaccharides. Acta Pharmacol Sinica 25(2):191–195
Zhang Y, Kong H, Fang Y, Nishinari K, Phillips GO (2013) Schizophyllan: a review on its structure, properties, bioactivities and recent developments. Bioactive Carbohydr Diet Fibre 1(1):53–71
Zhang Y, Ma G, Fang L, Wang L, Xie J (2014) The immunostimulatory and anti-tumor activities of polysaccharide from Agaricus bisporus (brown). J Food Nutr Res 2(3):122–126
Zhang ZF, Lv GY, Song TT, Jin QL, Huang JB, Fan LF, Cai WM (2015) Comparison of the preliminary characterizations and antioxidant properties of polysaccharides obtained from Phellinus baumii growth on different culture substrates. Carbohydr Polym 132:397–399
Zhao S, Rong C, Liu Y, Xu F, Wang S, Duan C, Chen J, Wu X (2015a) Extraction of a soluble polysaccharide from Auricularia polytricha and evaluation of its anti-hypercholesterolemic effect in rats. Carbohydr Polym 122:39–45
Zhao X, Ma S, Liu N, Liu J, Wang W (2015b) A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo. Carbohydr Polym 124:157–163
Zheng Y, Pang H, Wang J, Shi G, Huang J (2015) New apoptosis-inducing sesquiterpenoids from the mycelial culture of Chinese edible fungus Pleurotus cystidiosus. J Agric Food Chem 63(2):545–551
Zhu K, Nie S, Li C, Lin S, Xing M, Li W, Gong D, Xie M (2013) A newly identified polysaccharide from Ganoderma atrum attenuates hyperglycemia and hyperlipidemia. Int J Biol Macromol 57:142–150
Zhuan-Yun L, Xue-Ping Y, Bin L, Reheman HN, Yang G, Zhan S, Qi MA (2015) Auricularia auricular-judae polysaccharide attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress and inflammation. Biomed Rep 3(4):478–482
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Varghese, R., Dalvi, Y.B., Lamrood, P.Y. et al. Historical and current perspectives on therapeutic potential of higher basidiomycetes: an overview. 3 Biotech 9, 362 (2019). https://doi.org/10.1007/s13205-019-1886-2
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DOI: https://doi.org/10.1007/s13205-019-1886-2