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The diversity, antimicrobial and anticancer activity of endophytic fungi associated with the medicinal plant Stryphnodendron adstringens (Mart.) Coville (Fabaceae) from the Brazilian savannah

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Abstract

The diversity and biological activities of the endophytic fungi associated with the Brazilian medicinal plant Stryphnodendron adstringens were studied. A total of 320 fungal isolates were obtained, and 66 phylotypes comprising 25 genera were identified. The fungal community of S. adstringens displayed high richness, diversity and low dominance indices. The most abundant phylotypes were closely related to Diaporthe phaseolorum, Guignardia camelliae, and Preussia pseudominima. Sixteen fungal extracts displayed biological activities when screened against bacteria, fungi, cancer cell lines, and amastigote forms of Leishmania amazonensis. The extract of phylotype Nigrospora cf. oryzae exhibited a selective antifungal activity and inhibited the growth of Candida albicans and Cladosporium sphaerospermum. The extracts of Diaporthe cf. phaseolorum and Xylaria sp. phylotypes displayed anticancer activities. Our results indicate that the endophytes associate with this medicinal plant may be a source for novel drugs.

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Acknowledgements

This work received support from the Fundação of Amparo the Pesquisa of Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). The authors would also like to thank Dr. L. H. Pfenning for suggestions and Daniela N.B. Maia, Luciana F. Soares, and Fernanda L.M. Francisco for performing the biological assays.

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  1. Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais , P. O. Box 486, CEP 31270-901, Brazil

    Camila R. Carvalho, Vivian N. Gonçalves, Cristiane B. Pereira, Susana Johann, Isis V. Galliza, Carlos A. Rosa & Luiz H. Rosa

  2. Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil

    Tânia M. A. Alves & Carlos L. Zani

  3. Laboratório de Pesquisas Clínicas, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil

    Ana Rabello

  4. Departamento de Ciências Naturais, Universidade Federal de São João Del Rei, São João Del Rei, MG, Brazil

    Marcos E. G. Sobral

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  1. Camila R. Carvalho
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  2. Vivian N. Gonçalves
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  9. Carlos L. Zani
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  10. Carlos A. Rosa
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Correspondence to Luiz H. Rosa.

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Carvalho, C.R., Gonçalves, V.N., Pereira, C.B. et al. The diversity, antimicrobial and anticancer activity of endophytic fungi associated with the medicinal plant Stryphnodendron adstringens (Mart.) Coville (Fabaceae) from the Brazilian savannah. Symbiosis 57, 95–107 (2012). https://doi.org/10.1007/s13199-012-0182-2

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