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Curent Concepts in Pathology of Soft Tissue Sarcoma

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Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

Soft tissue sarcomas (STS) constitute a heterogeneous category of soft tissue neoplasia composed mostly of uncommon tumors of diverse histology, different biology and varied outcomes. Substantial developments in immunohistochemistry (IHC), cytogenetics and molecular genetics of STS have caused a significant change in the classification and diagnosis of these tumors with a direct implication for clinical management and prognosis. In this review we discuss newer developments impacting diagnosis and prediction.

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References

  1. Hogendoom PCW, Collin F, Daugaard S et al (2004) Changing concepts in the pathological basis of soft tissue and bone sarcoma tumor. Eur J Cancer 40:1644–1654

    Article  Google Scholar 

  2. Fletcher CDM, Unni KK, Mertens F (2002) WHO classification of tumors. Pathology and genetics of tumors of soft tissue and bone. IARC Press, Lyon

    Google Scholar 

  3. Fletcher CD (2006) The evolving classification of soft tissue tumours: an update based on the new WHO classification. Histopathology 48(1):3–12

    Google Scholar 

  4. Oliveira AM, Nascimento AG (2001) Grading in soft tissue tumors: principles and problems. Skeletal Radiol 30(10):543–559

    Article  PubMed  CAS  Google Scholar 

  5. Coindre JM, Trojani M, Contesso G et al (1986) Reproducibility of a histopathologic grading system for adult soft tissue sarcoma. Cancer 58(2):306–309

    Article  PubMed  CAS  Google Scholar 

  6. Guillou L, Coindre JM, Bonichon F et al (1997) Comparative study of the National Cancer Institute and French Federation of Cancer Centers Sarcoma Group Grading Systems in a population of 410 adult patients with soft tissue Sarcoma. J Clin Oncol 15(1):350–362

    PubMed  CAS  Google Scholar 

  7. Edge SE, Byrd DR, Carducci MA, Compton CC (eds) (2009) AJCC cancer staging manual, 7th edn. Springer, New York

    Google Scholar 

  8. Sobin LH, Gospodarowicz M, Wittekind Ch (eds) UICC TNM classification of malignant tumours. 7th ed. Wiley-Liss, New York, NY, in press

  9. Costa J, Wesley RA, Glatstein E, Rosenberg SA (1984) The grading of soft tissue sarcomas: Results of a clinico pathologic correlation in a series of 163 cases. Cancer 53(3):530–541

    Article  PubMed  CAS  Google Scholar 

  10. Brooks JS (1996) Immunohistochemistry in the differential diagnosis of soft tissue tumors. Monogr Pathol 38:65–128

    PubMed  CAS  Google Scholar 

  11. Folpe AL, & Cooper K (2007) Best Practices in diagnostic immunohistochemistry pleomorphic cutaneous spindle cell tumors. Arch Pathol Lab Med 131

  12. Heim-Hall J, Yohe SL (2008) Application of immunohistochemistry to soft tissue neoplasms. Arch Pathol Lab Med 132:476–489

    PubMed  Google Scholar 

  13. Fisher C (2010) Soft tissue sarcomas with non-EWS translocations:molecular genetic features and pathologic and clinical correlations. Virchows Arch 456:153–166

    Article  PubMed  Google Scholar 

  14. Fujimura Y, Ohno T, Siddique H et al (1996) The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t(12;22) chromosome translocation, encodes a constitutive transcriptional activator. Oncogene 12(1):159–167

    PubMed  CAS  Google Scholar 

  15. Ladanyi M (1995) The emerging molecular genetics of sarcoma translocations. Diagn Mol Pathol 4:162–173 Hirota S, Isozaki K, Moriyama Y et al (1998) Gain-of-function mutations in c-kit in human gastrointestinal stromal tumors. Science 279:577–580

    Google Scholar 

  16. Dei Tos AP (2001) Lipomatous tumours. Curr Diagn Pathol 7:8–16

    Article  Google Scholar 

  17. Bovée JVMG, Hogendoorn PCW (2010) Molecular pathology of sarcomas: concepts and clinical implications. Virchows Arch 456:193–199

    Article  PubMed  Google Scholar 

  18. Plougastel B, Zucman J, Peter M et al (1993) Genomic structure of the EWS gene and its relationship to EWSR1, a site of tumor-associated chromosome translocation. Genomics 18:609–615

    Article  PubMed  CAS  Google Scholar 

  19. Romeo S, Angelo P, Tos D (2010) Soft tissue tumors associated with EWSR1 translocation. Virchows Arch 456:219–234

    Article  PubMed  CAS  Google Scholar 

  20. Miettinen M, Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF (1999) Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis. Hum Pathol 30:934–942

    Article  PubMed  CAS  Google Scholar 

  21. Argani P, Antonescu CR, Illei PB et al (2001) Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents. Am J Pathol 159:179–192

    Article  PubMed  CAS  Google Scholar 

  22. Liegl-Atzwanger B, Fletcher JA, Fletcher CDM (2010) Gastrointestinal stromal tumors. Virchows Arch 456:111–127

    Article  PubMed  Google Scholar 

  23. Park MS, Ravi V, Araujo DM (2010) Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. Curr Opin Oncol 22:351–355

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Nuzhat Husain.

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Husain, N., Verma, N. Curent Concepts in Pathology of Soft Tissue Sarcoma. Indian J Surg Oncol 2, 302–308 (2011). https://doi.org/10.1007/s13193-012-0134-6

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  • DOI: https://doi.org/10.1007/s13193-012-0134-6

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