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Radio-graphene in Theranostic Perspectives

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Abstract

Owing to its unique physicochemical properties such as high surface area, notable biocompatibility, robust mechanical strength, high thermal conductivity, and ease of functionalization, 2D-layered graphene has received tremendous attention as a futuristic nanomaterial and its-associated research has been rapidly evolving in a variety of fields. With the remarkable advances of graphene especially in the biomedical realm, in vivo evaluation techniques to examine in vivo behavior of graphene are largely demanded under the hope of clinical translation. Many different types of drugs such as the antisense oligomer and chemotherapeutics require optimal delivery conveyor and graphene is now recognized as a suitable candidate due to its simple and high drug loading property. Termed as ‘radio-graphene’, radioisotope-labeled graphene approach was recently harnessed in the realm of biomedicine including cancer diagnosis and therapy, contributing to the acquisition of in vivo information for targeted drug delivery. In this review, we highlight current examples for bioapplication of radiolabeled graphene with brief perspectives on future strategies in its extensive bio- or clinical applications.

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Acknowledgments

This research was supported by a grant of the Korea Health Technology R&D Project funded by the Ministry of Health & Welfare, Republic of Korea (HI14C3344), and funded by the Ministry of Health & Welfare, Republic of Korea (HI14C1277), and the Technology Innovation Program (10052749) funded by the Ministry of Trade, Industry and Energy (MOTIE) of Korea.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Do Won Hwang

  2. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, South Korea

    Do Won Hwang

  3. Department of Nuclear Medicine, Seoul National University Hospital, 28 Yongon-Dong, Jongno-Gu, Seoul, 110-744, South Korea

    Do Won Hwang

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  1. Do Won Hwang
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Correspondence to Do Won Hwang.

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Do Won Hwang declares that he has no conflict of interest.

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This article does not contain any studies with animals performed by any of the authors. The manuscript has not been published before or is not under consideration for publication anywhere else.

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Hwang, D.W. Radio-graphene in Theranostic Perspectives. Nucl Med Mol Imaging 51, 17–21 (2017). https://doi.org/10.1007/s13139-016-0410-4

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